Surgical research
With the recent changes in the health care industry, surgeons face increasing pressure to devote their time to their clinical activities, thus limiting their research efforts. It is essential that young and creative individuals are encouraged to perform research and are given incentives to participate in research under the mentorship of more experienced research investigators. Surgical Research is the first book to include all the information necessary for the surgical scientist to perform a research experiment. The editors have assembled outstanding, expert investigators in multiple surgical fields and asked them to describe how they achieve their research accomplishments. In Surgical Research, these experts in the field have outlined everything involved in preparing and conducting a research project. Some of the topics covered in the book include how to state a research question, how to review the available information, how to write research protocol, how to obtain grant money for the experiment, how to analyze the data, and how to present the findings. Also discussed are the ethics of animal and human experimentation along with the history and philosophy of surgical research. To continue to advance technologies and surgical methods, research must continually be performed. Potentially great discoveries are being missed because would-be researchers do not know where to start or how to conduct research, and therefore do not even try. This book provides prospective researchers with all the basic steps needed to perform a research experiment in the surgical field. No student, resident, or fellow should start a research project without this book and no senior surgical scientist should be without it occupying a prominent position in the library. Key Features * The first complete compendium detailing the process and procedures to perform surgical research * Provides details on and compares various methodologies * A "must have" resource for the surgical resident, fellow, or scientist * Includes a listing of resources and web sites to help the researcher even further
1 online resource (xxxii, 1460 pages) : illustrations (some color)
9780126553307, 9781281795588, 9780080542140, 9786611795580, 0126553300, 1281795585, 008054214X, 6611795588
162129325
Contributors
Foreword
Preface
Getting Started
Assessing Available Information
Organizing and Preliminary Planning for Surgical Research
Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents
Grantsmanship
Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States Regulations
Animal Care and Maintenance
Funding Strategies and Agencies: Academic-Industrial Relationships; Intellectual Property
Statistical Considerations
Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment
Measuring Surgical Outcomes
Design of Clinical Trials
Using Administrative Data for Clinical Research
Research in the Intensive Care Unit: Ethical and Methodological Issues
Research in the Operating Room
Effects of Age and Gender
Strategies, Principles, and Techniques Using Transgenic and Knockout Mouse Models
Tissue Culture, Cell Growth, and Analysis
Hematopoietic Stem Cells: Basic Concepts and Applications to Surgical Research
Base Molecular Biological Methods in Surgical Research: Genetic Library Construction, Screening, and DNA Sequencing
Transcription
Signal Transduction and Apoptosis
Mechanisms and Regulation of Eukaryotic Protein Synthesis
Organelle Studies: Mitochondria, Golgi, and Endoplasmic Reticulum
Membrane Biology and Biophysics
Molecular Epidemiology: Beyond Gene Discovery to Clinical Diagnostic Tools
Shock Models: Hemorrhage
Scoring Systems for Trauma Research
Blunt Trauma Models: Fractures, Chest Trauma, Head Injury, Soft-Tissue Trauma, and Abdominal Trauma
Trauma Models for Studying the Influence of Gender and Aging
Animal Models of Burn Injury
Wound Care Models
Models of Adult Respiratory Distress Syndrome-Aspiration
Tumor Angiogenesis
Approaches to Adoptive Immunotherapy
Metastasis: Biology and Experimental Models
Cancer Genetics
Cancer Gene Therapy
Active Immunotherapy for Cancer
Gastrointestinal Motility
Models of Intestinal Secretion and Absorption
Surgical Models of Inflammatory Bowel Disease
Intestinal Regeneration and Adaptation Models
Minimally Invasive Surgery
Experimental Models and Endpoints for Studies of Intestinal Ischemia-Resperfusion Injury
Gut Barrier Failure
Developmental Studies in the Gastrointestinal Tract
Animal Models of Liver Failure
Portal Hypertension and Portacaval Shunt
Animal Models of Liver Regeneration
Animal Models for the Study of Hepatocyte Transplantation
Biliary Stone Formation
Models for the Study of Pancreatitis
Models of Endocrine Insufficiency
Animal Models in Transplantation
Models to Study Surgical Nutrition and Metabolism
Stable Isotopes
Body Composition
Energetics
Models of Protein Metabolism
Membrane Transport of Nutrients
Models of Wound Healing in Growth Factor Studies
Animal Models of Sepsis and the Multiple Organ Dysfunction Syndrome
The Immuno-Inflammatory Response
Antibiotic Trials
Scoring Systems for Sepsis and the Multiple Organ Dysfunction Syndrome
Cytokine Biology
Biology of Nitric Oxide: Measurement, Modulation, and Models
Endothelial Cell and Smooth Muscle Cell Biology in Vascular Disease
Coagulation Biology
Endovascular Research: Stents
Noninvasive Vascular Measurements
Techniques to Study Microcirculation
Blood Substitutes in Surgery
Research Models in Pediatric Surgery
Research in Fetal Surgery
Research in Plastic Surgery
Research Methods in Neurosurgery
Research in Urologic Surgery
Research in Cardiac Surgery
Research in Orthopedic Surgery
Statistical Analysis-Specific Statistical Tests: Indications for Use
Data Presentation: How to Write and Submit Abstracts and Papers
Audiovisual Communications as a Research Skill
Organizing and Managing Meetings and Conferences
The Management and Organization of a Surgical Research Laboratory
History and Philosophy of Surgical Research
The Surgical Research Program as a Business Enterprise
Nobel Laureates in Surgery
Surgical Education Research
Mathematical Modeling
Information Resource Discovery for Surgeons: Databases and the Internet
How to Review a Manuscript
Academic Surgical Mentoring
Ethics and Surgical Research
The National Institutes of Health: Procedures and Performance
Measuring the Performance of Surgical Research
Virtual Reality and Surgery
Surgeons and Health Services Research
From Idea to Product: Financing and Regulatory Issues in Product Development
English