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entirely lost,s". — Ringing in the ears,“9. — Insupportable tinkling in the

Nose.-Profuse bleeding of the nose at times,“:—Pain in the nasal fosse, as though he had inhaled Sulphuric acid," -Impaired smell,49 50.

Face.-At one time his face became very red, but soon afterwards was very pale, 5.--He has the aspect of astonishment, with hesitating speech and loss of memory,3%. -Countenance expressive of the most profound sadness," ---Convulsive movements of the lips,". - [870.] The lips were stiff;".

Mouth.-Stiffness of the tongue,".--Complete paralysis of the tongue,". -Salivation," --Constant desire to spit,92-Constant salivation, ".-Salivation, with constant desire to spit, 25. —Constant spitting on account of excessive secretion of saliva,"!. — Taste impaired,50. - Difficult speech, :-[880.] Speech became embarrassed,"$. - It was with difficulty that he could articulate his words, it seemed difficult to move the tongue,36 +I. - Extreme difficulty in expressing his ideas, the patient said his tongue would not work,“. -Experienced great difficulty in articulating words, because he could not move his tongue; the tongue seemed rigid and awkward, causing a kind of stammering,". - Loss of power of expressing his ideas; his tongue seemed to refuse its office,mo.

Stomach.-Increased appetite, - Appetite increased, digestion difficult, irregular, with colic, vomiting, and congestion,"5:- Enormous and insatiable appetite, "':--Appetite ravenous,"7:— Enormous appetite and voracious eating," —{890.] Ravenous appetite; the patient said he could eat all day

? - [ long, 3 — Marked diminution of appetite, 2 31 - Appetite very irregular,3* *7.

25.Complete loss of appetite,49:- Anorexia without vomitiog, 29.—Great thirst,2. -Great desire to drink,"4. -Constant nausea,"4. -Nausea without vomiting, 19 36 -[900.) Vomiting,". - Vomiting of food and glairy mucus,"?

-Violent vomiting at once ou taking food," -Acute pains in the stomach,". - Frequent cramps in the stomach,"

Abilomen. Fetid flatus,". Profuse fetid intestinal flatus,25. Colic,** 2,-Frequent colic, * -Violent colic,5 38-910.) Violent colic and .

] diarrhoea for three months, 2 -Very acute pain in the groin,".

Stool.-Profuse diarrhea, ".-Fetid diarrhea,”—Constant fetid diarrhea," --Diarrhoea with colic, ".-Frequent diarrhea, with sensation of smarting in the anus,a.- Alternations of constipation and diarrhea, "1 31 41.Intense constipation,*".

Uriny Organs.-Intense pain in the kidneys, 3 --[920.] Violent cutting in the urethra during micturition,'*.–Tenesmus of the bladder and frequent urgent efforts to urinate, and emission of two or three drops at a time," -- Micturition slow and painfu1,55— Micturition, associated with cutting pain in the urethra,".-Micturition painful, accompanied by acute burning pain,96 — Micturition excessively painful, with tenesnius and frequent desire to urinate; urine bloody,".-Smarting during micturition," :Frequent efforts to urinate; the urine was passed guttutim, accompanied by burning in the urethra, and tenesmus of the neck of the bladder,5%.Urine highly colored, ** – Urine turbid," —[930.] Urine pale and turbid, ". -Urine slightly albuminous, very red and turbid,50.-Urine red, containing an abuvdance of carbonate and phosphate of lime,".

Sexual Organs.-Erections difficult, the patient says “he reaches no result in five times,"55. —The testicles are very small,76. – Diminished size of the testicles, with diminished sensation on pressure, ** -- Testicles not painful to pressure, ".-Sexual excitement,4 38 43. — Excessive sexual excite

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ment,2447. — Excessive sexual excitement, constant fatiguing erections giving place speedily to complete impotency, ".--[940.) Sexual excitement sometimes amounting to the greatest intensity; at night in particular, he was often taken with veritable rage, during which he had coition with real fury," --Sexual excitement at first, followed after a time by complete loss of power; two or three times his wife became pregnant, but miscarried,"? -He became very amorous; erections, however, were seldom, coition much too long, and ejaculation short and incomplete, 36. — The sexual appetite at first increased, but afterwards diminished, until there was complete absence of desire ; at times an incomplete erection resulted in indefinite coition without emission; or at times an ejaculation was obtained with great difficulty, but was very profuse, ?:-Sexual excitement, with loss of power, -Sexual excitement after a time gave place to complete indifference, 25 31 etc.- At first sexual instincts were very much excited, but afterwards they disappeared, and at last there was complete impotency, -Complete loss of sexual power,26 41 49:—Sensation as though the genital organs were completely chilled, 96 -Symptoms of uterine catarrh, 16.—[950.) Profuse menstruation,'* - Menses arrested ; at the same time she became very large, and had the appearance of being pregnant; after a while she was seized with violent hæmorrhage, which lasted six months, and was only arrested by the use of ergotin,2. --All sexual sensation entirely disappeared; there was complete indifference to her husband, Respiratory Organs. - Voice feeble," - Deep bass voice, 24

. During the last two months the sounds of his voice became altered in tone, 94 — Tormenting cough and irritation of the bronchi,9— Breath fetid, ". - Very great difficulty of respiration on ascending stairs, 9. -Prolonged expiration, 43 — [960.] The forin of the chest was not at all altered, but expiration was more prolonged than normal,94 —Constant depression of breath,"-Gets out of breath easily,".

Chest.-Auscultation of the lungs showed prolonged expiration over the posterior portion, *. --Some emphysema of the lungs,".

Heart and Pulse.-The murmur of the first sound of the heart extended along the great vessels," — The volume of the heart was normal, but with the first sound there was a prolonged murmur, which extended along the vessels of the neck, **. -Slight murmur of the first sound of the heart,".. - Anæmic murmur of the heart,—Anæmic murmur in the large vessels,5% —[970.] It excites powerfully the activity of the heart and arterial system. Its internal use causes acceleration of the pulse, increased heat, and sanguineous congestion towards the skin and genito-urinary organs. The next remarkable secondary symptoms are abundant diaphoresis, increase of the urinary secretion and of the menstrual discharge, Palpitation,".— Violent palpitation," --Pulse moderately accelerated,"4. Pulse feeble, compressible, **

Neck and Back.-Pain and tension in the nape of the neck, followed by development of anthrax, which made rapid progress, was arrested by crucial incision, followed by extremely profuse suppuration ; this was followed by improvement and complete cure of the paralysis and general condition, 1-Pains in the back,34 --Pains in the loins, 36.

Extremities.-Trembling of the limbs,31 32 50. — Trembling of all the

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† Miscarringes are frequent among the women who work in rubber factories. # A short time afterwards the patient died from the rupture of a small aneurizm of the aorta.

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limbs, especially of the right side,“.—[980.] Rigidity of the limbs, 91 43 45. Rigidity of the limbs; this rigidity made rapid progress, involving all the principal articulations of the limbs,". — Marked rigidity and pains in the joints,"". — The tips of the fingers and toes became rigid and insensible, s. Stiffness of the limbs, 25 37. — Pronounced paraplegia, so that the limbs would not support the body,"9:- Paralysis and atrophy of the extensor muscles,“– Feebleness of the limbs,"4. -Walking was difficult; it was possible to stand upon the left leg with support of the bands, but not upon the right; while in bed the movements of the lower extremities were slow but perfect : motility of the hands was impaired, the fingers were in a state of semiflexion with contraction, but he was unable to extend them without a feeling of stiffness; attempts to grasp anything caused pain,26 - Pains in the limbs,* ** -1990.] Deepseated pains in the limbs, apparently in the bones and in the muscles, 40 – Deepseated pains in the limbs,** - Violent pains in the muscles of the limbs, 2-Fulgurating pains and sensations as of girdles about the limbs and body,50. — Very acute pains in the limbs, especially in the thick muscular portions, associated with cramps, especially in the lower extremities and in the feet,5— Extremely acute pains, sudden, lightninglike, in the limbs, aggravated by pressure; these flashes of pain accompanied the cramps; at night the intensity of the pains rendered sleep impossible, "".--Cramps in the extremities, 31 30:-Cramps in the right leg and arm,".-Frequent desire to stretch the limbs,92-Limbs feel tremulous, ". [1000.) Very peculiar and pronounced sensation of prickling in the extremities,40.- Very marked numbness of the extremities,50. —Loss of sensibility coincident with very acute pains in the articulations and along the limbs, aggravated by movement,26.

Superior Extremities. The upper extremities were feeble; the pressure of the hand was diminished in force, 6. — Terrible pains in the upper extremities, especially at night."!. — Very acute pains in the upper extremities, especially in the shoulder-joints," — Anästhesia extended over the upper limbs into the thorax," — Narked anesthesia of the arms and

30. hands,..-Prickling and tingling in the arms," - Extreme rigidity of the hands," — [1010.) Rigidity or insensibility of the hand,” - The hands became rigid and contracted, 50. —While lying in bed, the hands were habitually in a state of semiflexion, and could not be completely extended," The hands became rigid, painful, awkward ; extension and flexion were equally difficult,"? - Rigidity and awkwardness of the hands, * . -Diminished motility and sensibility of the right hand,".-Sensation on the backs of the hands very obtuse; the hands felt as if covered with a glove; the right was worse than the left,51. —Painful prickling and numbness of the hands,''-Anästhesia, numbness, and feebleness of the hands, " -The fingers became swollen, insensible, and difficult to flex or extend," :-[1020.] The fingers seemed rigid and insensible; she could not button her clothes, *. -The index finger was partially paralyzed with cramps,"7:— The digits became insensible, stiff, and awkward, unable to take hold of small objects, “. -Numbness of the digits, so that it is difficult to take hold of small objects, ".-Insensibility and awkwardness of the fingers,**.

Inferior Ectremities.-Trembling of the lower extremities," Gait hesitating,*. —Gait unsteady, 38 55. - Great feebleness of the lower extremities, so that walking was very difficult,35. —Walking became very difficult,“ - [1030.) While lying down he could move the lower limbs with cousiderable energy, but on attempting to rise found it very difficult to move them, especially the left,** -Walking very difficult, the left limb

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being more feeble than the right,"5—Loss of power in the lower extremities, - -Great loss of power of the lower extremities,".. — Very great rigidity of the lower extremities,".—Tormented by cramps of the thighs and soles, often lasting balf an hour,6 - Very painful cramps in the thighs and feet,"s. -Pains in the lower extremities, • — Prickling in the lower extremities, só. -Sensibility of the lower limbs impaired; the hands, forearms, and arms, especially at the insertion of the deltoid ; this loss of sensibility is not found on the body or in the face,26—[1040.) Diminished sensibility of the lower extremities,".—Complete insensibility of the lower extremities,55. At one spot on the upper portion of the left leg there is complete insensibility; over the whole extremity sensibility is impaired,--Rigidity of the knees, *. -Contractions and pain in the muscles of the calves, especially of the right, *.-Cramps in the calves and legs,"9:-(Edema of the ankles,... Insensibility of the skin of the feet, so that he did not know when the feet touched the ground,".

Generalities.- Pale and emaciated, 29. — Great awkwardness,**. [1050.] The patient is very awkward in her movements, ** —Constant twitching of the muscles,"?:--- Habitual trembling, often lasting twenty-four hours, in a very aggravated form," --Trembling of the whole body, especially of the upper extremities," : - Total loss of power,"0. — Loss of motion and sensibility of the whole right side of the body,".-Rigidity of the muscles,".--Analgesia of the right side, the patient could be pinched freely without sensation," —Hemiplegia became very pronounced ; sensibility of the right side of the body very slight; muscular contractility completely lost, but the paralysis was associated with a very pronounced degree of contraction, especially of the arm; every effort to extend it caused pain,". -Suddenly one day the face became very much congested, covered with perspiration, expression anxious, uncertain, the whole body covered with sweat, the hands trembled, pulse 120, bard; there were profuse diarrhoea, intense headache, vertigo, erratic pains, great muscular feebleness rendering the gait unsteady, very dim vision, rigidity of the hands, with prickling and diminished sensibility and very pronounced oppression of the chest, -1060.] On admission was lying on chair with all the muscles relaxed, face pale and covered with clammy sweat; lips blue and moist, with saliva and frothy mucus. Eyelids closed ; conjunctiva slightly sensitive to touch; pupils dilated and insensible to light. Breathing deep and laborious, almost stertorous; and the breath had a very strong odor of bisulphide of carbon. Pulse 110, regular, but very weak. On the next day, giddiness and slight headache, 2. -Loss of all energy,".- Extreme lassitude, -Great feebleness, 26 30 36 ---Easily fatigued, ".-General weakness," -Great muscular feebleness,50. —General muscular weakness, with a certain incoördination of the movements, like motor ataxia,'. — Tendency to faintness,“9. — Partial syncope, with convulsive movements of the extrenities,".—[1070.] Syncope, in which he fell to the ground, lost consciousness, and did not recover for a long time,.-Cutaneous hyperästhesia over the whole body except the fingers and toes," --She seemed to herself enormously swollen over her whole body,2*.-General pains, especially acute in the knees, ".--Cramps in the muscles," -The administration of Phosphorus seems to restore nearly all the cases; it seems almost a specific for this poisoning; but often at first there is an aggravation from very small doses," -The patient got out of the house, took a long walk, and returned home in complete disorder,".

Skin. --After it has been applied externally for a minute or two, a sen

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sation is felt as if several leeches were biting the part, and after the lapse of two to four minutes more the smarting and pain become rather severe. It is very seldom that any redness of skin is produced,”: - Development of a very large number of furuncles,35.- Very acute irritation of the skin, itching and smarting over the chest, thighs, and especially on the scrotum,“ -[1080.] Very violent itching of the scrotum, "". — Formication of the limbs," - Painful prickling and formication over the hands and feet,“.

Sleep.-Constant sleepiness; often during the night sleep disturbed by sad dreams, 59. —Sleepy during the day, sleepless during the night, Sleep prolonged and deep,“:—Sleep heavy and profound,» -Sleep profound, it was difficult to awaken him,5-Insomnia, 24 37, etc.-Alternations of constant sleepiness and wakefulness,18 —[1090.] Sleep restless, interrupted by starts,* *0.-Sleep disturbed by starting and constant waking: in the morning he was sleepy and difficult to rouse,"?:-Sleeplessness or sleep with distressing dreams, * -Sleep restless, tormented by distressing dreams, --Sleep interrupted by dreams,!. -Sad, fatiguing dreams, with a kind of hallucination that she was swolleu and enormously distended,46 — Terrible dreams of crimes committed under her eyes, :-Distressing dreams during sleep,

Ferer. - Sensation of general coldness, especially over the lower limbs,38 — Intense chilliness at night, followed by heat and profuse sweat,". -[1100.) Frequent horripilation," -Great sensitiveness to cold,"54 Fingers cold, rigid, with little sensation,*—Sensation of iey coldness in the lower extremities, 36. —Habitual coldness of the feet,".—Icy coldness of the feet and lower extremities," - Very profuse sweat,".-Habitual cold sweats,".

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CARUM.
Carum carui, L.
Natural order, Umbelliferae.
Common name, Caraway.
Preparation, Preparations from the dried fruit.

Authority. C. G. Mitscherlich, Pharm. Journ., vol. ix, 1819, p. 233, effects of large doses of cara way volatile oil.

Diarrhea.- Increased secretion of urine.-Excite the vascular system and the respiratory organs.

CASTOR.

p. 83.

Authority. 3, William Alexander, M.D., Exper. Essays, London, 1770,

[290] I took a bolus of 10 grains of Castor, made with a little syrup of

sugar. I felt no other effects than a few disagreeable eructations. The following day I took a bolus of drachm of Castor; the only effect it had was the eructations, which were pretty much the same as in the last experiment. Two days after this I took 1 drachm. The mercury in the thermometer at my stomach, which before taking it stood at 911°, was in an hour after risen to 925°, where it continued till the therinometer was removed. The eructations were not so frequent, nor so disagreeable as in the former experiments. The two following days, I took two more boluses of Castor ; the first containing 14 drachms, and the second 2 drachms. I was sensible of no other effect than the eructations, which, indeed, were

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