Neurobiology of DiseaseElsevier, 6. sep. 2011 - 1104 sider Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.
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Side 135
12. Ion. Channel. Disorders. Alan L. Goldin, MD, PhD Keywords: acetylcholine receptors, ataxia, epilepsy, GABA receptors, neuromuscular disorders, sodium channels 135 Figure 1 Diagram of a neuron showing the role of. I. Introduction II ...
12. Ion. Channel. Disorders. Alan L. Goldin, MD, PhD Keywords: acetylcholine receptors, ataxia, epilepsy, GABA receptors, neuromuscular disorders, sodium channels 135 Figure 1 Diagram of a neuron showing the role of. I. Introduction II ...
Side 136
... sodium and potassium channels. When the action potentials reach the axon ... Channel. Resting membrane potential (Cl, K) nACh Receptor (excitatory) GABAA ... channel families have been identified as causing human neurological diseases ...
... sodium and potassium channels. When the action potentials reach the axon ... Channel. Resting membrane potential (Cl, K) nACh Receptor (excitatory) GABAA ... channel families have been identified as causing human neurological diseases ...
Side 137
... Sodium channel SCN1A Nav11 Severe myoclonic epilepsy of infancy Sodium channel SCN1B 1 Generalized epilepsy with febrile seizures plus Sodium channel SCN2A Nav12 Benign familial neonatal-infantile seizures Sodium channel SCN2A Nav12 ...
... Sodium channel SCN1A Nav11 Severe myoclonic epilepsy of infancy Sodium channel SCN1B 1 Generalized epilepsy with febrile seizures plus Sodium channel SCN2A Nav12 Benign familial neonatal-infantile seizures Sodium channel SCN2A Nav12 ...
Side 138
... sodium channel. The subunit of the channel consists of four homologous domains labeled I–IV, with six transmembrane spanning segments termed S1–S6 in each domain. The P region between S5 and S6 in each domain forms part of the channel ...
... sodium channel. The subunit of the channel consists of four homologous domains labeled I–IV, with six transmembrane spanning segments termed S1–S6 in each domain. The P region between S5 and S6 in each domain forms part of the channel ...
Side 139
... channel is comparable to the subunit of the voltage-gated sodium channel and consists of four homologous domains labeled I–IV, each containing six transmembrane spanning segments termed S1–S6 and a P region. The 1 subunit includes the ...
... channel is comparable to the subunit of the voltage-gated sodium channel and consists of four homologous domains labeled I–IV, each containing six transmembrane spanning segments termed S1–S6 and a P region. The 1 subunit includes the ...
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abnormalities acid activity amyotrophic lateral sclerosis animal models antibodies antigens associated ataxia atrophy autism autoimmune axonal brain calcium cancer cause cellular central nervous system cerebellar cerebral chromosome Clin clinical cognitive cortex cortical creatine deficiency dementia dendritic diagnosis disorders dysfunction effects enzyme expression factors function gene genetic gliomas granule cell hippocampal human identified immune impairment increased infarction infection inflammatory involved lesions loss lymphoma lysosomal mechanisms medulloblastoma membrane meningiomas metabolism metastasis mice migraine mitochondrial molecular motor neuron mouse model multiple muscle mutations myelin myoclonus nerve neurological neuropathy Neurosci normal nucleus occur onset Parkinson’s disease pathogenesis pathology Pathophysiology pathways patients PCNSL phenotype potential primary prion progressive protein Purkinje cells receptor region response result role SCA1 seizures sodium channel spinal stroke studies subunit suggest symptoms syndrome synuclein systemic lupus erythematosus temporal lobe epilepsy therapy tion tissue transgenic treatment tumor vascular virus white matter
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