Neurobiology of DiseaseElsevier, 6. sep. 2011 - 1104 sider Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.
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Side v
... Ataxia Type 1 Harry T. Orr, PhD 14. Mitochondrial Genetic Diseases Alice Wong, PhD, and Gino Cortopassi, PhD 125 135 149 157 Section IV. Neuroimmunological Disorders Anthony T. Reder, MD 15. Paraneoplastic Neurological Disorders Steven ...
... Ataxia Type 1 Harry T. Orr, PhD 14. Mitochondrial Genetic Diseases Alice Wong, PhD, and Gino Cortopassi, PhD 125 135 149 157 Section IV. Neuroimmunological Disorders Anthony T. Reder, MD 15. Paraneoplastic Neurological Disorders Steven ...
Side 31
... ataxia of AMN. Hemizygous males present with difficulty in walking due to a combination of sensory ataxia and spastic paraparesis in the third decade; heterozygous females often display a milder myelopathy later in life. References T ...
... ataxia of AMN. Hemizygous males present with difficulty in walking due to a combination of sensory ataxia and spastic paraparesis in the third decade; heterozygous females often display a milder myelopathy later in life. References T ...
Side 37
... ataxia [2]. Experiments with murine brain slices indicate that guanidinoacetate partially activates -aminobutyric acid A (GABAA receptors at concentrations in the pathogenetically significant micromolar range. In the presence of GABA ...
... ataxia [2]. Experiments with murine brain slices indicate that guanidinoacetate partially activates -aminobutyric acid A (GABAA receptors at concentrations in the pathogenetically significant micromolar range. In the presence of GABA ...
Side 45
... ataxia, weakness, spasticity, and later dysarthria [29]. The juvenile form is characterized by later age at onset. The adult form is rare and is characterized by mild dementia and slowly progressive spasticity [30]. MRI findings reveal ...
... ataxia, weakness, spasticity, and later dysarthria [29]. The juvenile form is characterized by later age at onset. The adult form is rare and is characterized by mild dementia and slowly progressive spasticity [30]. MRI findings reveal ...
Side 46
cerebellar ataxia, and psychiatric symptoms [35]. MRI findings typically include a bilateral and almost symmetrical increase of the signal intensity on the T2-weighted images in the cerebellar and periventricular cerebral white matter ...
cerebellar ataxia, and psychiatric symptoms [35]. MRI findings typically include a bilateral and almost symmetrical increase of the signal intensity on the T2-weighted images in the cerebellar and periventricular cerebral white matter ...
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abnormalities acid activity amyotrophic lateral sclerosis animal models antibodies antigens associated ataxia atrophy autism autoimmune axonal brain calcium cancer cause cellular central nervous system cerebellar cerebral chromosome Clin clinical cognitive cortex cortical creatine deficiency dementia dendritic diagnosis disorders dysfunction effects enzyme expression factors function gene genetic gliomas granule cell hippocampal human identified immune impairment increased infarction infection inflammatory involved lesions loss lymphoma lysosomal mechanisms medulloblastoma membrane meningiomas metabolism metastasis mice migraine mitochondrial molecular motor neuron mouse model multiple muscle mutations myelin myoclonus nerve neurological neuropathy Neurosci normal nucleus occur onset Parkinson’s disease pathogenesis pathology Pathophysiology pathways patients PCNSL phenotype potential primary prion progressive protein Purkinje cells receptor region response result role SCA1 seizures sodium channel spinal stroke studies subunit suggest symptoms syndrome synuclein systemic lupus erythematosus temporal lobe epilepsy therapy tion tissue transgenic treatment tumor vascular virus white matter
Populære passager
Side 410 - Alizadeh, AA, Eisen, MB, Davis, RE, Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, JC, Sabet, H., Tran, T., Yu, X., Powell, JI, Yang, L., Marti, GE, Moore, T., Hudson, J.
Side 583 - ... marked impairment in the use of multiple nonverbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures to regulate social interaction b. failure to develop peer relationships appropriate to developmental level c. a lack of spontaneous seeking to share enjoyment, interests, or achievements with other people (eg, by a lack of showing, bringing, or pointing out objects of interest) d.
Side 583 - A. Qualitative impairment in social interaction, as manifested by at least two of the following: (1) marked impairment in the use of multiple nonverbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures to regulate social interaction (2) failure to develop peer relationships appropriate to developmental level (3) a lack of spontaneous seeking to share enjoyment...
Side 583 - ... play appropriate to developmental level (3) restricted repetitive and stereotyped patterns of behavior, interests, and activities, as manifested by at least one of the following: (a) encompassing preoccupation with one or more stereotyped and restricted patterns of interest that is abnormal either in intensity or focus (b) apparently inflexible adherence to specific, nonfunctional routines or rituals (c) stereotyped and repetitive motor mannerisms (eg, hand or finger flapping or twisting, or...
Side 532 - Gurney, ME, Pu, H., Chiu, AY, Dal Canto, MC, Polchow, CY, Alexander, DD, Caliendo, J., Hentati, A., Kwon, YW, Deng, HX, Chen, W., Zhai, P., Sufit, RL, and Siddique, T.
Side 533 - K. (1997). Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276, 1699-1702.
Side 240 - Atrial Fibrillation Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials.
Side 121 - Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O.
Side 431 - Pomeroy SL, Tamayo P, Gaasenbeek M. Sturla LM, Angelo M, McLaughlin ME, Kim JY. Goumnerova LC, Black PM, Lau C. Allen JC. Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA. Poggio T. Mukherjee S. Rifkin R. Califano A, Stolovitzky G. Louis DN, Mesirov JP, Lander ES.
Side 533 - Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Van Dorpe, J., Hellings, P., Gorselink, M., Heymans, S., Theilmeier, G., Dewerchin, M., Laudenbach, V., Vermylen...