Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the LiverAppleton-Century-Crofts, 1978 - 597 sider Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury. |
Indhold
The Spectrum of Hepatotoxicity3 | 3 |
Hepatic Metabolism of Foreign Compounds11 | 11 |
Vulnerability of the Liver to Toxic Injury32 | 32 |
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Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver Hyman J. Zimmerman Begrænset visning - 1999 |
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acid active administration adverse effects aflatoxin agents alcoholic alkaloids alkylated anabolic appears Arch bile biliary bilirubin biochemical Biol bromobenzene Cancer carbon tetrachloride carcinogenic carcinoma cause CCl4 cell centrizonal Chap chemical chloride chlorpromazine cholestasis cholestatic chronic cinchophen cirrhosis Clin clinical compounds cytotoxic doses drug metabolism drug-induced enhance enzyme ethanol ethionine evidence excretion experimental animals exposure factors fatal fatty liver Gastroenterology halothane hepa hepatic disease hepatic injury hepatic necrosis hepatocarcinogenic hepatocellular hepatocyte hepatotoxic hepatotoxic effects hepatotoxins histologic humans hypersensitivity incidence increased induced ingestion inhibition instances isoniazid jaundice Lancet lead lesion levels lipid liver damage liver disease liver injury mechanism membrane metabolite parenchymal Pathol patients percent Pharmacol phenobarbital plasma poisoning portal Proc produce hepatic injury protein pyrrolidizine rat liver reaction renal reported result rifampicin role serum SGOT species steatosis studies susceptibility syndrome synthesis therapy tion toxic toxic effects toxic metabolites Toxicol toxins treatment viral hepatitis