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ture, 507

400

Rheumatism, relation of tonsillitis to,

403

Richter, August Gottleib, 72
Riggs, John R., 380
Riolan, Jean, 44
Roman y Cajal, 101

Romans, medicine among, 8
Rome, fall of, 15

Rosenow, experimental work of, on
transmutability of strepto-
coccus-pneumococcus group,
316, 317, 318-320

Rosenow's theory of "virulins," 210
Ross-Jones modification of, Nonne and
Apelt Phase I reaction, 510

Rush, Benjamin, 70

on relation of systemic diseases to
oral sepsis, 379

Salivary glands, focal infection in,

327

Salvarsan, discovery of, 90
Salvarsan allergy, 161

Sandifort, Edward, 61
Santorini, G. D., 61

Santoro, Santorio, 44

Santoro iatro-mathematical school, 44

Saprophytes, infection by, 201

Saracens, advent of, into Europe, and
effect on learning, 16

Savonarola, Girolamo, 30

Scarlet fever infection in animals, 217
Scarpa, Antonio, 53, 77

Schaudinn, Fritz, 89

Schiff, Moritz, 97

Schleiden, Jacob, 98

Schoepf, Johann David, 65

Schwann, Theodore, 98

Scientific research, early, 39

Scleroderma, relation of oral sepsis to,
408

Secretions, internal, 96, 97, 404, 486.
See Internal secretions

Seminal vesicles, focal infection in, 331
Semmelweis, 88

Sensitizin, 122

Respiratory diseases, oral sepsis and, Septic meningitis, diffuse, cerebro-

Rhazes, 19

Rheumatic fever, secondary to focal

infection, 338

Rheumatism, relation of oral sepsis
to, 406

spinal fluid in, 534

Serous membranes, diseases of, sec-

ondary to focal infection,

336

acute peritonitis, 337

acute pleuritis, 336

Serous meningitis, cerebrospinal fluid

in, 534

differentiated from fluid in menin-
gitis sympathica, 537

Serum allergy, 162

edema in, 165

eruption in, 164

general, 164

local, 164

fever in, 164

frequency of, 163
heredity in, 166

incubation period of, 163

joints in, 165

leukopenia in, 165

lymph-nodes in, 165

mucous membranes in, 165
prevention of, 177

theories of mechanism of, 166
of von Pirquet and Schick, 166
"desensitizing" phenomena ab-
sent in, 175

incubation period after first in-
jection in, 167

Smith, Theobald, 89

von Soemmerring, Samuel Thomas, 54
Soranus, 9

Spain, medical learning of Moors and
Hebrews in, 21

Spallanzani, Abbate Lazaro, 54
Specificity, nature of, 107

Spinal cord, diseases of, oral sepsis
and, 411

infection of, of focal origin, 352
tumors of, cerebrospinal fluid in,

541

Spinal puncture, 494. See Lumbar

puncture

Spontaneous generation and putrefac-
tion, 85

Stahl, Georg Ernst, 66, 77

Staphylococcus infection, chronic, op-
sonic index in, 265

in different species, 217
Stoerck, Anton, 64

Stomach as portal of infection, 206

Streptococcus infection in different

species, 217

-

incubation period after reinjec- Streptococcus pneumococcus

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group,

transmutability of (Rose-
now's experiments), 316,
317, 318-320

Streptococcus viridans, 326, 335, 336
in chronic infectious endocarditis,

316

in disease of the heart, 404
in oral infections, 382, 383
relation of, to rheumatic conditions,
406, 407

Subcutaneous tissue as a barrier to in-
fection, 219

Sugar content of cerebrospinal fluid,
493

Sugar in urine, 445. See Glycosuria
in diabetes mellitus, increase of,
448, 451

diagnosis of, 452

carbohydrate administration in,
453

carbohydrate tolerance in, 452
fat elimination in, 452
persistent, 451

transient, 451

mechanism of production of, 447

in glycosuria associated with an
increase in concentration of
sugar in blood, 448

Sugar in urine, mechanism of produc- Syphilis of the nervous system, cere-

tion of, in glycosuria asso-
ciated with an increase in
concentration of sugar in
blood, alimentary glyco-
suria, 449

due to anesthetics, 450
due to injections, 450
due to injuries, 449

due to intravenous injections of
adrenalin, 450

due to lack of oxygen, 450
hepatic glycosuria, 451
pancreatic glycosuria, 450
pathological glycosuria, 449
in glycosuria not associated with

an increase in concentration
of sugar in the blood, 448
following caffein, theobromin or
diuretin administration,
448, 449

following phlorizin administra-
tion, 448

following sodium chlorid by
intravenous injection, 448

tests for, Fehlings, 445
Superstition, medicine and, 1
Surgery, ancient practice of, 12, 13
antisepsis in, first use of, 87
history of, 72, 93

Paré's contribution to, 43
Süssmilch, Johann Peter, 74
Swammerdam, Jan, 40
van Swieten, Gerhard, 70
Sylvius, 34

iato-chemical school of, 44
Syphilis, diagnosis of, by Bruck's
nitric acid reaction in
cerebrospinal fluid, 518

colloidal gold test in, 522

Wassermann reaction in, 276. See

Wassermann reaction

application of, 286

diagnosis by, 90

Wassermann reaction for cerebro-

spinal fluid in, 516

specificity of, 517

infectiveness of, in species, 216

meningeal involvement in, cerebro-
spinal fluid in, 534

Syphilis, cerebral, cerebrospinal fluid
in, differentiated from fluid
in meningitis sympathica, 536

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Toxophore group in Ehrlich's side.
chain theory, 225

Trachea as portal of infection, 205
Transfusion of blood, selection of
donors in, agglutination

tests for, 250

Traube, Ludwig, 103

Trichinosis, cerebrospinal fluid in, 538
Tsuchiya modification of Esbach test
for quantitative estimation
of protein in urine, 457

Tuberculin allergy, 190
Tuberculin reaction, 185
theories of phenomena of, 185
Tuberculin sensitiveness, 185
Tuberculosis, avian, infectiveness of,
in different species, 216
bovine, infectiveness of, in different
species, 215

human, infectiveness of, in different
species, 215

oral sepsis and, 402
Tuberculous meningitis, cerebrospinal
fluid in, 534

differentiated from fluid in acute
anterior poliomyelitis, 538

in meningitis sympathica, 537
lumbar puncture in, 531

Tumors of the brain, cerebrospinal

fluid in, 541

lumbar puncture in, 532

Tumors of the spinal cord, cerebro-
spinal fluid in, 541

Typhoid fever infection in different
species, 217

Typhus infection in animals, 218

Urea, discovery of laboratory produc-
tion of, 83

in cerebrospinal fluid, 493
Ureters, focal infection of, 331
URINALYSIS, 423

acetone bodies in urine in, 442

acetone, 442

beta-oxybutyric acid, 442

diacetic acid, 442

metabolic derivation of, 443
tests .for, 445

acidity determinations of urine in,

433

hydrogen-ion acidity in, 435
titration acidity in, 433
acids in the urine in, 440

Urinalysis, reducing substances in,

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sugar in, mechanism of
production of, in glyco-
suria associated with an
increase in concentration
of sugar in blood, due to
injections, 450

due to injuries, 449
due to intravenous injec-
tions of adrenalin, 450
due to lack of oxygen, 450
hepatic form, 451
pancreatic form, 450
pathological glycosuria, 449
in glycosuria not associated

with an increase in con-
centration of sugar in the
blood, 448

following caffein, theobro-
min or diuretin adminis-
tration, 448, 449

following phlorizin admin-

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