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Lumbar puncture, after-treatment of,
artificial respiration in, 507

atropin in, 506

codein in, 506

hyoscin in, 506
ice-cap in, 506
morphin in, 506
pyramidon in, 506

rest in bed in, 506

stimulation in, 507

amount of fluid withdrawn in, 506

anesthesia for, 507

chloroform in, 507

cocain in, 507

ethyl chlorid in, 507

novococain in, 507

as a therapeutic procedure, 531

in acute bacterial meningitis, 531

in cerebral hemorrhage, 532

in hydrocephalus, 532
in purulent meningitis, 531
in serous meningitis, 532

in syphilis of the nervous system,
533

in tuberculous meningitis, 531
in tumors of the brain, 532
aseptic precautions in, 498
death following, 495
headache following, 507

needles and apparatus necessary for,
498

position of patient in, 497

recumbent, 497

sitting, 498

site of puncture in, 500

technic of puncture in, 501

Lungs as portal of infection, 205
focal infection in, 328
Lymphatic circulation, discovery of,

38

Lymph-nodes, focal infection in, 327
systemic diseases due to, 328

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Lysins in Ehrlich's side-chain theory, Martin and Cherry on toxin-antitoxin

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in diagnosis, 533

sugar content of, 493

diffuse septic, cerebrospinal fluid in,

534

epidemic cerebrospinal,

lumbar

puncture in, 531. See also
Cerebrospinal fever

otitic, cerebrospinal fluid in, 534
purulent, lumbar puncture in, 531
serous, cerebrospinal fluid in, 534
differentiated from fluid in
meningitis sympathica, 535

lumbar puncture in, 532

Meningitis, tuberculous, cerebrospinal
fluid in, differentiated from

fluid in meningitis sym-
pathica, 537

lumbar puncture in, 531
Meningomyelitis, syphilitic, cerebro-
spinal fluid in, differenti-
ated from fluid in acute
anterior poliomyelitis, 538

Mercury allergy, 159

Mestrezat total protein test in exami-
nation of cerebrospinal
fluid, 510

Metabolism, discovery of, 83

study of, original investigations in,
96

Metchnikoff, Eli, 90

experiments of, on extracellular
lysis, 268

theory of phagocytosis, by leuko-
cytes, 221, 259
Methodist school of medicine in Rome,
8, 9

Microscope, discovery of, 39
Microscopic investigation, growth of,

39

Middeldorff on cerebrospinal fluid, 476
Migraine, oral sepsis and, 411
Milk sugar in urinalytic tests, 447
Miller, W. D., on oral sepsis, 380, 381
Molière, 42, 45

Monro, Alexander, 52

Moors, advent of, into Europe, and ef-
fect on learning, 16, 21
Morgagni, Giovanni Battista, 60
Morphin sulphate in lumbar puncture,
506

sympathica, cerebrospinal fluid in, Morton, William T. G., 91

534, 535

Moscheowitz, Eli, 91

of, 253

differentiated from fluid in brain Moss, microscopical agglutination test

abscess, 536

in brain tumor, 537

in cerebral syphilis, 536

in encephalitis, 537

in meningitis aseptica, 535

in poliomyelitis, 537

in serous meningitis, 535
in tuberculous meningitis, 537
syphilitic, cerebrospinal fluid in, 534
tuberculous, cerebrospinal fluid in,

534

differentiated from fluid in acute

anterior poliomyelitis, 538

on agglutination of blood-serum in
different individuals, 250,

251

Mouth infection, 377. For main sub-
ject see under Oral sepsis

definition of, 377

local manifestations of, 377
Mucous membranes as a barrier to in-
fection, 219

Müller, Johannes, 94

Multiple sclerosis, cerebrospinal fluid
in, 540

Muscles, diseases of, oral sepsis and, Neurasthenia, oral sepsis and, 356, 410

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354

Neuraxis, inflammatory lesions of, 539
Neuritis, oral sepsis and, 351, 411
Nightingale, Florence, 105
Nitrous oxid anesthesia, 91
Noguchi, Hideyo, 89

butyric acid test of, for globulin in
examination of cerebro-
spinal fluid, 510

Nolf physical theory of anaphylactic
shock, 153

Myositis, secondary to focal infection, Nonne, spinal fluid syndrome of, 488
Nonne and Apelt Phase I reaction in
examination of cerebro-
spinal fluid, 510

Nasal sinus as portal of infection, 205

Nasal tract, etiologic focal infection Nose, examination of, in diagnosis of

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relation of, to systemic disease, Nursing, growth of, 105

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Opsonic index, 262

principle of, 262

reasons for failure of, 263
technic of, 263

value of, 265

as a guide to dosage of bacterial
vaccines, 265

in auto-inoculation following vac-
cination, 266

in chronic staphylococcus infec-
tions, 265

in negative phase following vac-
cination, 265, 266
Opsonins in immunity, 260
relation of, to phagocytosis, 260
in immune serum, 260, 261, 262
in normal serum, 261, 262

Obstetrics, history of, 73
O'Halloran, Sylvester, 77
Ophthalmology, history of, 77
Oral examination in diagnosis of focal
infection, 360

Oral focal infection, 326, 327

in dental and alveolar tissues, 326
frequency of, in systemic disease,
326

infective agent of, 326
systemic diseases secondary to,
326, 327

in salivary glands, 327
ORAL SEPSIS, 377

definition of, 377

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Pecquet, Jean, 38

Petit, Jean-Louis, 77

Pettenkofer, Max von, 96, 104

Periapical abscess of teeth, 385, 387
definition of, 377

Periapical infection of teeth, 385, 387,

392, 393

Pneumatist school of Rome, 9
Pneumococcus, determination of types
of, by agglutination tests,

249

by precipitin test, 257

Pneumococcus infection in different
species, 217

Pericarditis, acute, focal infection in, Pneumonia, oral sepsis and, 401

336

chronic, focal infection in, 336
Pericardium, diseases of, secondary to
focal infections, 336
acute pericarditis, 336
chronic pericarditis, 336
Peritonitis, acute, secondary to focal
infection, 337

Petechia secondary to focal infection,

343

Pfeiffer, investigation of bacteriolysis
by, 267, 268

phenomenon of, 267

Phagocytosis in immunization, 90, 221,

259

chemotaxis in, 259

leukocytes in, functions of, 259
Metchnikoff cellular theory of, 221
opsonins in relation to, 260

in immune serum, 260, 261, 262
in normal serum, 261, 262
other theories of, 222
Phagosin, 259

Pharmacology, growth of, 103
Philolaos, 4

Physical theory of anaphylactic shock,
153

Physiological chemistry, development
of, 95

Physiology, history of study of, 50, 93
von Pirquet and Schick theory of me-
chanism of drug allergy, 166
"desensitizing" phenomena absent
in, 175

incubation period after reinjection
in, 170

local edema at site of reinjection in,

173

other clinical phenomena in, 173
Plague infection in different species,

216

Pleurisy, oral sepsis and, 401

Pleuritis, acute, secondary to focal in-
fection, 336

Pliny, the younger, 9

Poliomyelitis, acute anterior, cerebro-
spinal fluid in, 537

differential diagnosis of, 538
differentiated from fluid in men-

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