Doses of Medicines for Injection into the Urethra. The quantity mentioned is intended for solution in a fluidounce of distilled water. Doses of Medicines for Injection into the Vagina. The amount mentioned is intended for solution in a pint of water, unless otherwise stated. In gonorrhoea of the female, many of the solutions already mentioned under "Urethral Injections," which may not be repeated in this place, are also applicable, as a general rule, for vaginal injection, but the proportion of the active ingredient, and especially the quantity of solution employed, must be increased. Doses of Medicines in the form of Suppositories. The excipient usually employed in the formation of suppositories is oleum theobromæ, or cacoa butter, on account of its possessing the desirable consistence and fusibility for the purpose. Suppositories for young children should not weigh more than five or ten grains; for adults, they may weigh twenty-five or thirty grains. The U. S. Pharmacopoeia recommends thirty grains, the British Pharmacopoeia only fifteen. The usual dose of the active ingredient of the suppository may be from one and a half to two times that of the same medicine administered by the mouth. In city practice the physician usually mentions the quantity of the medicine in his prescription, leaving the exact size of the suppository to the manipulation of the pharmacist; or the latter keeps on hand a full line of ready-made suppositories in anticipation of the needs of the practitioner. The general subject of suppositories includes those intended for introduction into the rectum, vagina, uterus and urethra. Doses for Rectal Suppositories. The quantity mentioned of each article is intended to be mixed with an excipient, preferably cacoa butter (oleum theobroma), according to the rules and manipulations familiar to pharmacist and physician.1 (See Opium.) Acidum tannicum, gr. iij-x. Creasotum, m-ss. Cupri acetas, gr. ij. sulphas, gr. ij. Elaterium, gr. ss. stramonii, gr. j. Extractum stramonii, gr. j; plumbi acetas, gr. ij. Extractum stramonii, gr. j; acidum tannicum, gr. v. Ferri perchloridum, gr. ij. 66 subsulphas, gr. j-iij. Gallæ. (See Opium.) Gambogia, gr. iij-vj. (See Ex- Hydrargyri chloridum mite, gr. Extractum belladonnæ, gr. -ij. sulphas, gr. 7-j. (See Extractum belladonnæ.) Morphiæ sulphas, gr. ss; acidum tannicum, gr. iij. Oleum theobroma. Opium, gr. iv. (See Pulvis ipecacuanha compositus.) Opium, gr. j; acidum gallicum, gr. ij. Opium, gr. j-ij; acidum tannicum, gr. ij-v. Opium, gr. j; extractum hyoscy- Opium, gr. j; galla, gr. v. Plumbi acetas, gr. ij-v. (See Opium, Extractum belladonna, Plumbi acetas, gr. ij; acidum tan- (For the officinal suppositories, Suppositoria, U. S. Phar., see Pharmacopæial Groups.) Sapo. Pulvis ipecacuanhæ compositus, gr. Sodii sulphas, 3j. Plumbi iodidum, gr. ij. Tinctura assafoetidæ, mxl. Zinci sulphas exsiccata, gr. ij. Doses for Vaginal Suppositories. These conical preparations for the introduction of remedies per vaginam usually weigh about a drachm or more; and are shaped like a minié bullet, but somewhat larger. The quantity mentioned of each article is the proper dose for a suppository : As elsewhere stated, suppositories are usually made with oleum theobroma as the excipient, but Dr. Meadows, in his address before the British Medical Association in 1871, remarks: "Inasmuch as it is no part of the function of the vaginal mucous membrance to digest fats, and as fats without digestion cannot be absorbed, and are apt, moreover, to hinder the absorption of other substances, it is desirable, I think, that we should not use greasy substances of any kind. For this reason I long ago gave up the employment of cacoa butter, and I now invariably use, as the basis of the pessary, gelatin and glycerine, into which we can put any ingredient we wish." Tannic acid, and other substances incompatible with gelatin, cannot, however, be thus administered. Plumbi acetas. gr. v; opium, gr. Potassii iodidum, gr. v-x. Doses for Uterine Suppositories. Suppositories for introduction into the cervical canal are cylindrical in shape, and about two inches long, having a diameter similar to a No. 9 male catheter. They should weigh about fifteen grains:— Acidum gallicum, gr. j. 66 Extractum opii aquosum, gr. ij. gallicum; opium, ãã gr. j. Ferri perchloridum, gr. j 66 tannicum, gr. j. Morphiæ murias, gr. j. sulphas, gr. j. Plumbi acetas, gr. j. 66 tannicum, opium, āā gr.j. Argenti nitras, gr. j. Cupri sulphas, gr. ss. Zinci sulphas exsiccata, gr. j. Doses for Urethral Suppositories (Soluble Bongies). This form of surgical treatment of gonorrhoea and gleet consists of firm smooth cylinders, two or three inches long, made of cacoa butter, having a diameter similar to a No. 9 bougie, and containing some remedial agent incorporated in it. This soluble bougie, well oiled, may be introduced by the patient himself into the urethra, preferably at bedtime, and will gradually dissolve in about ten minutes. The bougie may be retained by proper adjustment of slips of adhesive plaster.' |