Role of Melatonin and Pineal Peptides in Neuroimmunomodulation

Forsideomslag
Franco Fraschini, Russel J. Reiter
Springer Science & Business Media, 6. dec. 2012 - 329 sider
Research related to the pineal gland has advanced rapidly in the last three decades since the discovery of its most important hormone, melatonin. This indoleamine has been shown to have a large variety of effects in the organism; the bulk of these actions were initially thought to relate the pineal gland to the reproductive and endocrine systems. It is now apparent, however, that the physiologic interactions of the pineal and its hormones far transcend its control of endocrine function. One field of pineal research that has developed rapidly within the last 5 years has been the demonstration of its relationship to the immune system. Since the pineal gland is part of the central nervous system, these observations generally fall in the category of neuroimmunology, an area that, in its own right, has received a great deal of attention in the last decade. Thus, a NATO Advanced Study Course entitled "Role of Melatonin and Pineal Pep tides in Neuroimmunomodulation" was convened in Erice, Sicily, on June 3-9, 1990. This book is a result of the scientific presentations given at the workshop. The contributions to the book include mini-review articles which summarized the presentations of the invited speakers as well as a selected number of brief communications where the subject matter was in line with the theme of the Advanced Study Course.
 

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Indhold

Some Open Morphological
1
Demonstration of Nerve Fibers Immunoreactive
15
Comparative Studies of VIP PHI and NPYImmunoreactive
27
Pharmacological Regulation of ReceptorMediated
35
New Aspects Concerning the Regulation
57
The Use of Perifusion Technique in
67
InterferonY Modulates Indoleamine Metabolism
79
MELATONIN RECEPTORS
85
Melatonin Enhances GABAMediated Effects when Administered
191
Action of Melatonin on Immune System
201
Opioids in Immune Cells
211
Spleen Morphology and Lymphoproliferative Activity in Short
219
Melatonin Action on Oncogenesis
233
The Effects of Melatonin and Melatonin Analogues on
241
Melatonin Immunity and Cancer in Humans
253
Evidence for a SexSpecific Facilitatory Effect of Melatonin
263

Melatonin Binding Sites in the Nervous and Immune Systems
107
Melatonin in the gastrointestinal tract
127
Biochemical Characteristics of Melatonin Receptors in Different
137
Annual Changes in the Daily Pattern of Melatonin Synthesis
147
Integration of Environmental Signals by the Pineal Gland
158
Effect of Melatonin on NADHOxidoreductase Activity
173
Temporal Profile of Superoxide Dismutase Activity in
181
Interactions and their Possible Importance
273
Immunological
281
Circadian Profile of Serum Melatonin in Cushings Syndrome
293
Urinary 6Sulfatoxymelatonin Excretion in Breast Cancer
301
Contributors e e e e e e e e e e
313
Index e e e e s e s e
321
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