shrinking of the stroma of the iris from connective tissue changes and shortening by adhesions, also from synechia. in its perispherical area. By this very shortening the blood vessels appear numerous as they are brought nearer together.
Primary glaucoma may be induced. by a physiological change as age adAfter forty years the lens becomes thicker, firmer, and the anterior chamber shallow; hence more and more danger from glaucoma. The narrow shallow anterior chamber may be physiological and hence where hypermetropia exists there is more danger of glaucoma.
Secondary glaucoma is due to pathological changes in the eye. These two glaucomas, primary and secondary, are clinically different, but not different from a pathological standpoint. In long standing cases of secondary glaucoma you will see little or nothing of
the stroma of the iris as atrophy and absorption has taken place.
Among the many causes of secondary glaucoma we note the following:
Luxation of the lens, either spontaneous or from traumatism, either laterally or into the vitreous or into the anterior chamber.
Injury of the lens and swelling of the lens substance also produce like results. Operations upon the eye may be followed by glaucoma.
Perforating wounds and ulcers of the cornea followed by incarceration of the iris produce a very dangerous condition liable at any time to set up intraocular pressure.
The essential factor in these cases is a more or less obstruction to the filtration angle from adhesions.
In some fundus changes which have no relation to the anterior part of the eye, glaucoma follows, as in case of retinal hemorrhage and tomors. This
DRAWING FROM SLIDE 72. From a case of glaucoma ectropium pigmenti.
From a case of glaucoma ectropium pigmenti. This slide is from an advanced case of glaucoma. Marked changes in the iris, advanced atrophy, are shown as well as like changes in the ciliary body. Connective tissue has replaced much of the stroma of the
iris. On the right the pigment layer is pulled over the anterior surface of the pupillary margin, as is often the case when contraction and atrophy of the iris occurs. On the left the filtration angle is completely obliterated. The stroma of the iris and that of the cornea are united.
may be accounted for by vitreous ede- ma and forward pressure.
The results following serous-cyclitis or iritis, from any cause, often enter into the etiology of glaucoma. Hence we place by themselves the following conditions:
(1) Seclusion of pupil with retention of the aqueous in the posterior cham- ber, producing often iris bombe.
(2) Changes in the pectate ligament, followed by its inability to take up the aqueous-impairment of filtration need not be complete, but only partial. De Vries (Amsterdam) examined the iris angle in twenty-four eyes enucleated for glaucoma and found in every case the Knies-Weber closure of the angle. In only part of the cases was the entire circumference of the ligamentum pec- tinatum involved.
(3) Most important and usual-peri-
spherical synechia produced by a shal- low anterior chamber, or resulting from an irido-cyclitis.
Dilatation of the pupil assists in clos- ing the angle of the iris to some extent. The sucking action of the canal of Schlemm only makes the position of iris worse drawing it back into the an- gle. Pressure from secretion also in- creases this condition.
Again in some cases we find no mis- placement of the entire root of the iris, but an edematous swelling of the fil- tration area at the root of the iris.
We must not forget that not infre- quently a reoccurrence of the glaucoma takes place from an iridectomy made for its relief.
Treatment-The usual operation of iridectomy is useless if there is a firm fibrous union at the filtrate angle or if
From a case of glaucoma bullae cornea, coloboma artificiate iridis. This was a case of primary glau- coma, but subsequently became sec- ondary as the loss of lens shows. The changes in epithelium on the anterior surface of the cornea are also shown. An iridectomy of no value was made, ectasia followed the iridectomy and this was operated upon, but again the ectasia occurred and the eye was enu- cleated. The incision for the iridec-
tomy is not shown in this section. The section is made in the inferior segment of the eye below the pupil, hence the iris shows abnormal length on the right side. On both sides the filtration angle is completely blocked and on the right side fibres of the iris and those of the
are indistinguishable, connec- tive tissue having replaced the normal tissue in this region. A high degree of atrophy of the ciliary body is also seen.
connective tissue changes have oc- curred in the pectate ligament so that it is unable to perform its physiological function. Grosz (Budapest) records the favorable results of iridectomy for glaucoma in two hundred and thirty- seven (237) cases, as follows: In the prodromal stage ninety-six (96) per cent successful; in the active stage,
eighty-seven (87) per cent successful; and in glaucoma simplex, seventy (70) per cent successful.
In many cases a broad iridectomy, removing a section of the iris down to its ciliary attachment, will produce all the favorable results in glaucoma that are now known to medicine or surgery. The incision can be made with a Graef
DRAWING FROM SLIDE 74.
(Posterior portion of eye shown in slide 72.) Glaucomatous excavation of optic nerve.
The changes seen in the optic nerve are the results of inter-ocular pressure. The weakest place in the eye tunics is where the nerve enters the globe. Hence, when pressure occurs it is the first place to give way.
In the early stages the lamina crib- rosa forms a curve with the concave surface toward the vitreous. From pressure the nerve fibres atrophy, hence there is a real loss of substance as well as a true ectasia. All these changes become greater as the case progresses until at last the lamina cribrosa may be even on a posterior plane to that of the sclerotic. The sclerotic now overhangs the disc and all signs of total optic atrophy are seen. Nearly all writers attribute these
changes to internal pressure. But while attending Professor Schnable's clinic, I found that he considers that the lamina cribrosa is pulled back, not pressed back, by the shrinking of the neuroglia of the nerve, spaces forming in the nerve back of the lamina cribrosa and this receding to fill these spaces. These conclusions were reached from a careful study of forty-two glaucomatous eyes. But it is not impossible that in some of these cases of Professor Schna- ble's, optic atrophy followed papillitis, which is sometimes a forerunner of glaucoma.
The glaucomatous cup is not empoy but is filled by the vitreous, or, in severe cases, with new-formed connective tis-
knife or a keratome and should be one and one-half mm back from the cornea in the scleral tissue and at least eight mm in length, following the curve of the cornea. Now one of two methods can be employed: One, used often in the Royal Ophthalmic Hospital, London, in which the iris is seized firmly with a forcep and a sec- tion "torn out by its roots. The other method, which I prefer, is to seize the iris, pull it strongly to one side of the incision, cut one-half close to the globe, then pull likewise to the other angle of the incision and cut in like manner.
In the shallow anterior chamber the knife is preferable to the keratome, as the keratome is more liable to injure the lens. In Fuch's Clinic, Vienna, Heine's operation of cyclodialysis is re- sorted to where the anterior chamber is so shallow as not to permit the usual iridectomy operation or where the iridectomy has failed to give relief. Meller, chief assistant in Fuch's Clinic, stated to me that the operation was without serious danger. That in most cases the eye became soft to normal tension in two or three days after the operation. In older cases a longer time. elapsed; that sometimes the tension did not return. In this clinic the op- eration was considered one of much value. Heine prefers cyclodialysis to iridectomy in many cases. Cases of double operation in which one eye was operated upon by iridectomy and the other by cyclodialysis, the latter showed the most favorable results. He considers it less dangerous than iridec- tomy. These conclusions are based upon fifty-six operations.
The operation is as follows: An in- cision through the conjunctiva and the sclera two mm long is made five mm from the sclero-corneal margin parallel with the same. Scissors are used to cut the conjunctiva, and the point of a keratome the sclera. Now, a very thin metal iris replacer is carried under the sclera, hugging its inner surface, into the anterior chamber, the point enter- ing between the pectate ligament and the sclera, the point is swung about
to make a free opening into the an- terior chamber and then withdrawn. Care is exercised to make the incision between the ciliary vessels.
In cases of hopeless, painful glau- comatous eyes, optico-ciliary neuroto- my proves of value to the patient, re- lieving them of their suffering and does not disfigure as does enucleation.
I desire to report one case to illus- trate under what erratic and variable forms glaucoma may appear, violating all rules: In 1905 I was called by Dr. Earnheart of Oklahoma City to see a patient in his practice. Found an un- usually plethoric, robust girl of twelve years of age, who always had enjoyed perfect health. Prior to her present trouble she had not had change in sur- roundings or diet and no excessive use of the eyes. Three days before my visit she had suddenly been seized with a pain in the left eye followed by red- ness and heat. From the first this con- dition had grown more and more se- vere until when I saw her she had been unable to sleep for twenty-four hours and had been confined to the bed moan- ing with pain in her eye.
A superficial examination showed the symptoms of an acute iritis, but upon more careful scrutiny I found ten- sion markedly increased, cornea cloudy with sensation greatly reduced. All the symptoms of an acute primary inflam- matory glaucoma were present. Anti- phlogistic treatment with eserine was diligently employed for eight hours with no favorable results, and as the case was growing worse, I made a very broad iridectomy. In two hours the girl was asleep. The case made an uneventful recovery. The other eve was and has always remained normal. Two weeks ago, after eighteen months, I refracted this eye, gave +1.00 axis 180°, which gave a vision of 20-20. Since the first attack no ocular trouble has been experienced. Among other interesting things in this case, the age of the patient, the fact that the glau- coma affected only one eye, the un- known cause, and the perfect results from the iridectomy are noticeable.
WILLIAM BRITT BURNS, M. D.
Surgeon to City Hospital, Division Surgeon Frisco System.
Case One-E. A. P. Male aet, 25 was referred to me by Dr. B. F. Tay- lor, of Marked Tree, Arkansas, October 17, 1905.
I found him at the City Hospital suf- fering great pain, and crying out.
History-Had acute pains in region of the gall bladder 15 years ago, last- ing four days; thinks he had no fever. Had some pains, not so acute in in- tervals of one to four months. In ad- dition to pains, had for eigheen months prior to coming into my hands, what he termed "flush-like" risings of temperature, one-half to one degree, about two hours after meals; with per- spiration of legs and palms.
Operation-The usual incision was made at ninth rib and abdominal straight muscle. The gall bladder was. found distended to twice its normal size, phlegmonous and necrotic areas; an abscess in the posterior wall of the gall bladder, containing about a dram of very white pus. A mulberry, choles- terine stone .5 cm. by .9 cm. was found blocking the cystic duct. The stone. was removed and the operation of chol- ecystectomy was done. The stump of the cystic duct was tied off with silk and a double layer of serous cuff su- tured over the stump. Abdomen closed in the usual three layers. There was not an untoward symptom; he had neither pain, fever nor accellerated pulse; left the hospital in absolutely first-class shape. He was not very anxious to regain his muscular strength; he had been a lieutenant in the German army and was accustomed to violent and outdoor exercise. the twenty-ninth day he walked five miles, in the morning and at about 2 o'clock P. M. of that day, stepped down off a high coping on the street, and
Read before Frisco System Medical As- sociation, sixth annual meeting at St Louis, Mo., September 24th and 25th, 1907.
fell to the ground suffering great pain in region of wound.
I at first attributed his pain to pull- ing on adhesions in neighborhood of stump. Waited until the next morning, and opened up and found the belly full of bile, and plastic material over vis- cera. Peritonitis. Death. Autopsy showed that the omentum which had gone up and around the stump of the cystic duct, in the first place had been pulled away by the sudden and prob- ably awkward step off of the coping. Pretty good hard luck story?
Case Two-F. M. Male 35.
History Of syphilis and evidence of same. I had seen him in several at- tacks of pain in region of ball bladder. Diagnosed; cholecystitis with probable gall stones. Operation was done. The usual incision was made-at junction of ninth rib with abdominal straight muscle. Chronic interstitial inflamma- tion of the gall bladder was found; veri- fied by the microscopic examination. The walls were friable and cholecys- tectomy was done. Rapid and unin- terrupted progress up to the ninth morning, when evidence of pulmonary embolus set up. His lung was put in splint. Morphine. Recovery.
Case Three-W. H. Male, age 23. Gun shot of the abdomen; entering right flank on level with umbilicus, passing downward and to the left, burying in the abdominal wall in up- per left ilias region. Had been shot eleven hours. The bullet passed through one knuckle of small gut and through mesentery.
Abdomen opened in median line; perforations closed, wiped with wet gauze (saline); belly filled with saline solution and closed. Fowler position. Recovery.
Case Four-Gun shot wound of ab- domen. Bullet entered about junction of ninth rib with outer border of rec- tus muscle. Two perforations in car- diac end of stomach and one in mes- entery. Had been shot three hours. Wiped out all blood clots and par- ticles of food, etc., after having closed Mickulicz drain and perforations;
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