Surgical ResearchWiley W. Souba, Douglas W. Wilmore Elsevier, 23. feb. 2001 - 1460 sider With the recent changes in the health care industry, surgeons face increasing pressure to devote their time to their clinical activities, thus limiting their research efforts. It is essential that young and creative individuals are encouraged to perform research and are given incentives to participate in research under the mentorship of more experienced research investigators. Surgical Research is the first book to include all the information necessary for the surgical scientist to perform a research experiment. The editors have assembled outstanding, expert investigators in multiple surgical fields and asked them to describe how they achieve their research accomplishments. In Surgical Research, these experts in the field have outlined everything involved in preparing and conducting a research project. Some of the topics covered in the book include how to state a research question, how to review the available information, how to write research protocol, how to obtain grant money for the experiment, how to analyze the data, and how to present the findings. Also discussed are the ethics of animal and human experimentation along with the history and philosophy of surgical research. To continue to advance technologies and surgical methods, research must continually be performed. Potentially great discoveries are being missed because would-be researchers do not know where to start or how to conduct research, and therefore do not even try. This book provides prospective researchers with all the basic steps needed to perform a research experiment in the surgical field. No student, resident, or fellow should start a research project without this book and no senior surgical scientist should be without it occupying a prominent position in the library. Key Features * The first complete compendium detailing the process and procedures to perform surgical research * Provides details on and compares various methodologies * A "must have" resource for the surgical resident, fellow, or scientist * Includes a listing of resources and web sites to help the researcher even further |
Indhold
| 1 | |
| 3 | |
| 9 | |
| 13 | |
| 23 | |
| 29 | |
| 47 | |
| 63 | |
Chapter 52 Biliary Stone Formation | 721 |
Chapter 53 Models for the Study of Pancreatitis | 733 |
Chapter 54 Models of Endocrine Insufficiency | 747 |
Chapter 55 Animal Models in Transplantation | 757 |
Chapter 56 Models to Study Surgical Nutrition and Metabolism | 773 |
Chapter 57 Stable Isotopes | 789 |
Chapter 58 Body Composition | 797 |
Chapter 59 Energetics | 813 |
| 71 | |
| 81 | |
| 101 | |
| 115 | |
| 127 | |
| 137 | |
| 155 | |
| 167 | |
| 175 | |
| 193 | |
| 207 | |
| 217 | |
| 233 | |
Chapter 22 Signal Transduction and Apoptosis | 253 |
Chapter 23 Mechanisms and Regulation of Eukaryotic Protein Synthesis | 271 |
Mitochondria Golgi and Endoplasmic Reticulum | 285 |
Chapter 25 Membrane Biology and Biophysics | 297 |
Beyond Gene Discovery to Clinical Diagnostic Tools | 307 |
Hemorrhage | 317 |
Chapter 28 Scoring Systems for Trauma Research | 331 |
Fractures Chest Trauma Head Injury SoftTissue Trauma and Abdominal Trauma | 347 |
Chapter 30 Trauma Models for Studying the Influence of Gender and Aging | 357 |
Chapter 31 Animal Models of Burn Injury | 367 |
Chapter 32 Wound Care Models | 379 |
Chapter 33 Models of Adult Respiratory Distress SyndromeAspiration | 393 |
Chapter 34 Tumor Angiogenesis | 401 |
Chapter 35 Approaches to Adoptive Immunotherapy | 415 |
Biology and Experimental Models | 435 |
Chapter 37 Cancer Genetics | 445 |
Chapter 38 Cancer Gene Therapy | 457 |
Chapter 39 Active Immunotherapy for Cancer | 497 |
Chapter 40 Gastrointestinal Motility | 507 |
Chapter 41 Models of Intestinal Secretion and Absorption | 533 |
Chapter 42 Surgical Models of Inflammatory Bowel Disease | 547 |
Chapter 43 Intestinal Regeneration and Adaptation Models | 557 |
Chapter 44 Minimally Invasive Surgery | 573 |
Chapter 45 Experimental Models and Endpoints for Studies of Intestinal IschemiaReperfusion Injury | 583 |
Chapter 46 Gut Barrier Failure | 599 |
Chapter 47 Developmental Studies in the Gastrointestinal Tract | 613 |
Chapter 48 Animal Models of Liver Failure | 623 |
Chapter 49 Portal Hypertension and Portacaval Shunt | 637 |
Chapter 50 Animal Models of Liver Regeneration | 703 |
Chapter 51 Animal Models for the Study of Hepatocyte Transplantation | 709 |
Chapter 60 Models of Protein Metabolism | 825 |
Chapter 61 Membrane Transport of Nutrients | 845 |
Chapter 62 Models of Wound Healing in Growth Factor Studies | 857 |
Chapter 63 Animal Models of Sepsis and the Multiple Organ Dysfunction Syndrome | 875 |
Chapter 64 The ImmunoInflammatory Response | 893 |
Chapter 65 Antibiotic Trials | 909 |
Chapter 66 Scoring Systems for Sepsis and the Multiple Organ Dysfunction Syndrome | 921 |
Chapter 67 Cytokine Biology | 933 |
Measurement Modulation and Models | 949 |
Chapter 69 Endothelial Cell and Smooth Muscle Cell Biology in Vascular Disease | 971 |
Chapter 70 Coagulation Biology | 989 |
Stents | 1001 |
Chapter 72 Noninvasive Vascular Measurements | 1011 |
Chapter 73 Techniques to Study Microcirculation | 1027 |
Chapter 74 Blood Substitutes in Surgery | 1037 |
Chapter 75 Research Models in Pediatric Surgery | 1047 |
Chapter 76 Research in Fetal Surgery | 1065 |
Chapter 77 Research in Plastic Surgery | 1081 |
Chapter 78 Research Methods in Neurosurgery | 1095 |
Chapter 79 Research in Urologic Surgery | 1107 |
Chapter 80 Research in Cardiac Surgery | 1119 |
Chapter 81 Research in Orthopedic Surgery | 1137 |
Indications for Use | 1201 |
How to Write and Submit Abstracts and Papers | 1217 |
Chapter 84 Audiovisual Communications as a Research Skill | 1237 |
Chapter 85 Organizing and Managing Meetings and Conferences | 1241 |
Chapter 86 The Management and Organization of a Surgical Research Laboratory | 1249 |
Chapter 87 History and Philosophy of Surgical Research | 1261 |
Chapter 88 The Surgical Research Program as a Business Enterprise | 1279 |
Chapter 89 Nobel Laureates in Surgery | 1287 |
Chapter 90 Surgical Education Research | 1299 |
Chapter 91 Mathematical Modeling | 1309 |
Databases and the Internet | 1319 |
Chapter 93 How to Review a Manuscript | 1337 |
Chapter 94 Academic Surgical Mentoring | 1343 |
Chapter 95 Ethics and Surgical Research | 1349 |
Procedures and Performance | 1361 |
Chapter 97 Measuring the Performance of Surgical Research | 1375 |
Chapter 98 Virtual Reality and Surgery | 1383 |
Chapter 99 Surgeons and Health Services Research | 1393 |
Financing and Regulatory Issues in Product Development | 1405 |
Index | 1415 |
Andre udgaver - Se alle
Almindelige termer og sætninger
acid activity adenovirus administration analysis anesthesia anesthetic angiogenesis angiogenic antibody antigen apoptosis artery assay assessment Autologous tumor cells binding Biol blood bowel cancer carcinoma cDNA cell lines cellular Clin clinical trials clones colon complex culture cytokine disease effects endothelial epithelial cells evaluation experimental function gastric gene expression gene therapy genetic genomic growth factor healing human identified immune immunotherapy induced injection Institutional Review Board intestinal investigator involving kinase knockout laboratory Laceration lung injury lymphocytes marker measure Medical melanoma membrane metastasis metastatic method mice molecular molecules mouse mRNA mucosa mutations Natl normal outcome patients peptide phase phenotype potential procedures protein protocol randomized receptor regulation Research Subjects response Retrovirus risk score sepsis sequence specific Surg surgery Surgical Research target technique tion tissue transcription factor transgenic trauma treatment variable vascular vector virus vitro vivo wound