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bear the tin&ture perfectly well, when opium in substance does not agree with them.'

In answering some objections that have been started against this mode of cure, the author allows, that quickness of the the pulse and copious fweats, will fometimes supervene at the beginning of a course of opium ; but thele fymptoms will either go off of themselves, or else will be removed by giva ing the bark along with the opium. Weakness and supervening fallowness of complexion, will likewise give way to this medicine. Trembling of the hands, which might caufe alarm, he also confidently asserts, is of no consequence, as it will soon disappear. Several other objections he seems to answer in a fatisfactory manner ; but all objections arising from hypothesis, must give way to facts, and accordingly we find a relation of twenty-one cases in the remaining part of this paper. We have endeavoured to exhibit the most material circumstances attending these cases, in the following Table, which we hope, with what has been already faid, will convey a very full idea of Dr. Michaelis's observations. The Table itself does not stand in need of any explanation : It may only be necessary to premise what could not be expressed in the table, that the patients had taken no medicines, at least no mercury, except where this is noticed.

ENG. Rev. Vol. V. JUNE. 1785.




| Dofe in a Day.

Extract Theb. gr. iv.--gr.viij.

Time of Cure. about five


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fourteen days


gr. iij--3ss.

five weeks


gr, iij--xxiv.

abour eleven



Chief Symptoms.
Ulcers of penis, &c. &c.
No gonorrhea
Ulcers of throat from virus long latent
No gonorrhea
Ulcers of the penis, and throat-buboes
Phymosis, gonorrhea
Nocturnal pains
Ulcer of penis, fauces
Condylomata about the anus
Recent ulcer of penis, ' bubu
No gonorrhea
Large ulcer on the thigh and penis,
Bubo, nocturnal pains
No gonorrhea
Bubo, ułcer, and chancre on the prepuce
Ulcer and condylomata of private parts
No fuelling of ingl. glands
No gonorrhea
Ulcer of prepuce, chancres
Paraphy mofis


Oberw.tions. Cure interrupted by fever Speedy amendment of the ulcers in the.

external application of opium Intection faid to have been received more

than two years before had fhewed itselt,

and yielded to mercurys
Disease of five months. standing, had taken

ro medicines,
Gonorh. two years before, no treth intection
Relapse and speedy recovery
grains of

corrotive Tublimate had
been taken
:D, of one year and half standing
Relapse and speedy recovery
Had taken corrolive fublimate
Cure appeared rapid at first
External application tried; but would not

produce an entire cure
Had taken corrofive tublimate, and was

growing worse

gr. iij.-vi.

nine weeks

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five weeks


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V. S. and purging premited on

of the inflammation
Three weeks before, a partial cure by

mercury dulc.
A woman, and had been infected five years,

and twice salivated
Many other symptoms during the use of

the opium, inercury afterwards failed


gr. iij-v.

£. £.
gutt. x-xl.
2. q. hora.
Extract Theb.
gr. jij-xiv.

Swelled glands, nocturnal pains

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Uicers of private parts, buboes
Eruption of forehead

Gonorrhea, phyinons


Chancres 21 Condylomata, no gonorrhea, or chancre

gr. 11j-v.

not cured

Mercury produced no material good effect


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This is certainly a fair prospect; but have others found the same good effects from opium? We fear not. We know indeed, that in one or two instances it has produced a permanent cure, but in many others it has only alleviated the symptoms. Accordingly, the other playficians in America foon defifted from its use, and this has likewife been the case in our own country. But considering the attention it has excited, we cannot remain long without further information on this subject. But whatever may be the final decision, Dr. Michaelis's paper is curious and valuable, if it were only for an account of the effects of opium given for a considerable time in large doses. We hope full confidence may be placed in his observations. His excellent thesis, and the way in which this paper is written, incline us to believe this. But we must acknowledge, that several medical perfons who we.e in America with Dr. Michaelis do not speak of him with so much respect as we thought he would command wherever he went.

Of the articles which remain, the fuccceding, viz. Observations on the causes, symptoms, and cure of consuínption's, &c.' is the most curious. It contains leveral new observations, and does credit to Dr. Stark's accuracy. But we are afraid, that many of the expressions are far too general, and that all the distinctions are not well founded. Do large blood vessels, for example, never open into vomicæ ? veral questions of this nature will arise in the mind of the attentive reader; and his doubts will not be diffipated, when he is told by the editor of thefe obfervations, Dr. C. Smith, that the author was a young physician, whose experience was confined almost entirely within the walls of St. George's Hospital, a circumstance, which, while it must raise him in the estimation of his reader, sufficiently, indicates that his general conclusions 1hould be received with great caution.

The remaining articles are :

An account of a hydrocephalus internus of prodigious fize in an adult, by Dr. Michaelis.

An account of a method of curing the hydropthalmia by means of a seton, by Mr. Ford.

An account of a tumour, supposed to have been a diseased kidney, by Mr. Fearon.

An account of a cancerous affection of the stomach, by Dr. Sims.

Another, by Dr. C. Smith.

An account of a painful affection of the antrum maxillare, from which three infects were discharged, by Dr. Heytham, of Carlife.


An account of an hairy excrescence in the fauces of a newborn infant, by Mr. Ford.

In the preface we are given to expect a second volume in no long time, an intimation which we received with pleasure, as the present volume cannot fail to impress the public with a very favourable opinion of the society.

ART. VIII. An Attempt to prove the Existence and absolute Perfectiin

of the Supreme Unoriginated Reing, in a demonstrative Manner. By Hugh Hamilton, D.D. F.R.S. Dean of Armagh. 8vo. 35. 6d. sewed. Robinson. London, 1785,

F all the branches of human knowledge, natural theo

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objeet, the nobleft, and merits our most serious attention. It is the prerogative of man, among all the inhabitants of this earth, to be capable of knowing his creator, of worshipping him, and of imitating his perfections. There is no fpecies of science that tends to much to enlarge and clevate the mind as the knowledge of God. It is the Itrongest support of every virtue, and the only rational foundation of tranquillity and peace of mind, of hope and comfort, of magnaniinity and fortitude, in all the various circumstances of life. All genuine piety must be founded on juft ideas of the perfections and providence of God. It is true, Revelațion teaches the truths of natural religion, as well as other truths which our reason could never have discovered. But it is equally true, that reason, as well as revelation, comes from God. Both are lights granted to us by the Father of Lights, and we ought to make the best use of both, and not to extinguish the one that we may use the other. It must be confeffed indeed, that revelation has been of great use to enlighten men even with regard to the truths of natural religion. This is evident by comparing the systems of natural religion which are to be found in Christian countries with those that have appeared among the most enlightened Heathens. But there is no good cause why we thould not still make use of our reasoning powers. Revelation is given to men as reasonable creatures, and it is by rçafon alone that we can judge of the truth of revelation, and whether any system is juftly entitled to that appellation. It is by reason also that we muit judge of the meaning of what is revealed, and guard against such interpretations of it as are absurd, impious, or inconfiftent. The existence of a Supreme Being, the maker and governor of the world, is so loudly proclaimed by all the works of nature that fall within our observation, more especially in the wonderful constructure of our bodies, and the


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