injection, use very fine needles, and deliver the injection into the areolar tissue beneath the skin, instead of into the skin, as lay parties generally do for themselves. I have given injections of Morphine and Atropine to a dying girl 3 and 4 times daily for two months, and never produced a sore. Always force out all fluid, and wipe the needle-point dry between the fingers, before returning it to the case; the sebaceous matter on the fingers There is an area of several inches square, on the upper and keeping it free from rust. exterior aspect of the thigh, just below the great trochanter of the femur, which is remarkably insensible, being sparingly supplied with cutaneous nerves. (See Fig. 307, Gray's Anatomy, 10th English edition.) An injection delivered in this area will not be felt by the patient. Avoid puncturing a vein; if you do so, watch the patient and prepare an injection containing gr. of Atropine Sulphate, to administer if dangerous symptoms arise. Never, except under special circumstances, administer the salts of Morphine or Atropine hypodermically to children less than 15 years of age.

CHLORODYNE.

A COMPARISON OF ITS INGREDIENTS, ACCORDING TO TEN FORMULÆ THEREFOR, THE QUANTITIES BEING CALCULATED FOR EACH FORMULA TO A FOUR-QUNCE MIXTURE, OR m 1920.

NOTE. See ante, page 169, for remarks on this preparation, and the number of formulæ representing it. *Author of "A Companion to the Br. Pharmacopœia."

See Hartshorne's "Essentials," 5th ed., p. 625.
Made by Eli Lilly & Co., Indianapolis.

2d ed., page 430.

**Parke, Davis & Co., Detroit.

Tinct. Chloroformi et Morphinæ, B. P.

PATENT MEDICINES.

NOTE.-These formulæ have been published from time to time in various journals and formularies, and are supposed to represent the preparations designated. The name of the author is appended in each case when known.

The most energetic poisons are Hydrocyanic Acid, some reptile poisons, Strychnine, and Nicotine. (See pages 67, 288, 381.) Those usually selected for criminal purposes are Arsenic, Colchicum, and Tartarized Antimony, the symptoms of which resemble those of natural disease.

General Principles of Treatment. Jeaunel's General Antidote.-R. Liq. Ferri Sulphatis (sp. gr. 1.45) 3ijss; Magnesiæ Calcinat. 3ij; Carbonis Animalis 3j; Aquæ 3xx. The ingredients should be kept separate-the solution of the sulphate in one vessel, the others together. When needed, the former should be added to the latter and violently agitated. Dose, 3jss to iij. This is a perfect antidote to Arsenic, Zinc, Digitaline, etc. It delays the action of salts of Copper, Morphine and Strychnine, and slightly influences compounds of Mercury. It is valueless for Cyanide of Mercury, Tartar Emetic, Hydrocyanic Acid, Phosphorus, or the caustic Alkalies.

BELLINI, of Florence, considers the Iodide of Starch a valuable antidote to alkaline Sulphides, earthy Sulphides, vegetable and caustic Alkalies, and Ammonia. In the first two cases, he considers it superior to all other antidotes.

A fresh mixture of the Sulphide of Iron, Magnesia, and the Sulphide of Sodium, is a perfect antidote for salts of Copper, the Bichloride of Mercury (Corr. Sub.), and the Cyanide of Mercury.

If the nature of the poison is unknown, a harmless yet in most cases effectual antidote is: R. Magnesiæ, Carbonis Ligni, Ferri Oxidi Hydrati, aa partes æquales; Aquæ q. s. Give ad libitum.

Castile Soap, dissolved in 4 times its bulk of hot water, drunk by the cupful, is one of the best remedies in many cases, especially poisoning with metals, corrosive acids or corrosive vegetable substances. It is injurious in cases of alkali poisoning.

Albumen. White of egg, dissolved in water, is especially useful for metallic substances.