AddictionOUP Oxford, 26. sep. 2013 - 144 sider Part of the Oxford Psychiatry Library series, this pocketbook is a clear and comprehensive overview of the brain science underpinning addiction and how this helps explain the current and future therapeutics for the range of addictions, using full colour images to enhance understanding. Addiction focuses on the nature of addiction as a brain disorder that includes a range of different behavioural traits such as impulsivity and reward dependence, and discusses the critical role of kinetic and pharmacological factors. The text explains how the primary pharmacological targets of drugs of abuse are now understood, the relation to the variable nature of addiction to different substances, and how this may lead to new approaches to treatment. |
Indhold
5 Drug pharmacokinetics and abuse liability | 8 |
6 Pharmocodynamics of addictive substances | 14 |
7 The dopamine system and addiction | 20 |
8 The GABA system and addiction | 32 |
9 The glutamate system and addiction | 8 |
10 The opioid system and addiction | 12 |
| 20 | |
| 22 | |
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abstinence abuse liability acamprosate activity addictive substances agonist alcohol dependence amphetamine antagonist associated attenuating Baclofen behaviour benzodiazepines buprenorphine carfentanil caudate chronic clinical cocaine abusers cocaine dependence cognitive control Copyright cortex craving cues diazepam disorders dopamine neurons dopamine release dopamine system dopamine transporter dose drug effects of cocaine effects of substances efficacy endorphins Figure functioning GABA system Gabapentin genetic glutamate heroin humans impulsivity induce inhibition inhibitory involved medications methadone methamphetamine methylphenidate midbrain Modafinil motivation mu opioid receptor N-acetylcysteine NAcc naltrexone neural Neuropsychopharmacology neurotransmitter neurotransmitter systems NMDA receptor nucleus accumbens Opiates opioid receptor opioid system pathway permission from Elsevier Pharmacodynamics pharmacokinetics Pharmacology placebo pleasure presynaptic processes putamen reducing cocaine reinforcing effects relapse Reprinted Research reuptake reward circuitry shown significantly stimulants striatal substance abuse substance addiction substance rewards substances of abuse substances of addiction synaptic system and addiction Tiagabine tion Topiramate treatment ventral striatum Vigabatrin Volkow ND
