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from the aorta. And the same proportion in these particulars is universally preserved. The more muscular and powerful men are, the firmer their flesh; the stronger, thicker, denser, and more fibrous their hearts, the thicker, closer, and stronger are the auricles and arteries. Again, in those animals the ventricles of whose hearts are smooth on their inner surface, without villi or valves, and the walls of which are thin, as in fishes, serpents, birds, and very many genera of animals, the

arteries differ little or nothing in the thickness of their coats from the veins.

Moreover, the reason why the lungs have such ample vessels, both arteries and veins (for the capacity of the pulmonary veins exceeds that of both crural and jugular vessels), and why they contain so large a quantity of blood, as by experience and ocular inspection we know they do, admonished of the fact indeed by Aristotle, and not led into error by the appearances found in animals which have been bled to death, is, because the blood has its fountain, and storehouse, and the workshop of its last perfection, in the heart and lungs. Why, in the same way, we find in the course of our anatomical dissections the pulmonary vein and left ventricle so full of blood, of the same black colour and clotted character as that with which the right ventricle and pulmonary artery are filled, is because the blood is incessantly passing from one side of the heart to the other through the lungs. Wherefore, in fine, the pulmonary artery has the structure of an artery, and the pulmonary veins have the structure of veins. In function and constitution and everything else the first is an artery, the others are veins, contrary to what is commonly believed; and the reason why the pulmonary artery has so large an orifice is because it transports much more blood than is requisite for the nutrition of the lungs.

All these appearances, and many others, to be noted in the course of dissection, if rightly weighed, seem clearly to illustrate and fully to confirm the truth contended for throughout these pages, and at the same time to oppose the vulgar opinion; for it would be very difficult to explain in any other way to what purpose all is constructed and arranged as we have seen it to be.

THE THREE ORIGINAL PUBLICATIONS ON VACCINATION

AGAINST SMALLPOX

BY

EDWARD JENNER

INTRODUCTORY NOTE

EDWARD JENNER was born at his father's vicarage at Berkeley, Gloucestershire, England, on May 17, 1749. After leaving school, he was apprenticed to a local surgeon, and in 1770 he went to London and became a resident pupil under the great surgeon and anatomist, John Hunter, with whom he remained on intimate terms for the rest of Hunter's life. In 1773 he took up practise at Berkeley, where, except for numerous visits to London, he spent the rest of his life. He died of apoplexy on January 26, 1823.

Jenner's scientific interests were varied, but the importance of his work in vaccination has overshadowed his other results. Early in his career he had begun to observe the phenomena of cowpox, a disease common in the rural parts of the western counties of England, and he was familiar with the belief, current among the peasantry, that a person who had suffered from the cowpox could not take smallpox. Finally, in 1796, he made his first experiment in vaccination, inoculating a boy of eight with cowpox, and, after his recovery, with smallpox; with the result that the boy did not take the latter disease.

Jenner's first paper on his discovery was never printed; but in 1798 appeared the first of the following treatises. Its reception by the medical profession was highly discouraging; but progress began when Cline, the surgeon of St. Thomas's Hospital, used the treatment with success. Jenner continued his investigations, publishing his results from time to time, and gradually gaining recognition; though opposition to his theory and practise was at first vehement, and has never entirely disappeared. In 1802, Parliament voted him £10,000, and in 1806, £20,000, in recognition of the value of his services, and the sacrifices they had entailed. As early as 1807, Bavaria made vaccination compulsory; and since that date most of the European governments have officially encouraged or compelled the practise; and smallpox has ceased to be the almost universal scourge it was before Jenner's discovery.

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Το
C. H. PARRY, M.D.

AT BATH
MY DEAR FRIEND:

In the present age of scientific investigation it is remarkable that a disease of so peculiar a nature as the cow-pox, which has appeared in this and some of the neighbouring counties for such a series of years, should so long have escaped particular attention. Finding the prevailing notions on the subject, both among men of our profession and others, extremely vague and indeterminate, and conceiving that facts might appear at once both curious and useful, I have instituted as strict an inquiry into the causes and effects of this singular malady as local circumstances would admit.

The following pages are the result, which, from motives of the most affectionate regard, are dedicated to you, by Your sincere friend,

EDWARD JENNER. BERKELEY, GLOUCESTERSHIRE,

June 21st, 1798.

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