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number of cases in which its use is contraindicated for various reasons. Chief among these is the fact that some persons exhibit so pronounced an idiosyncrasy toward quinine, that even the administration of comparatively small doses is followed by marked gastrointestinal irritation and nervous phenomena, such as vertigo, headache, deafness, blindness, etc. There are other persons who, while not intolerant to quinine, derive little or no therapeutic effect from its use. The physician is therefore obliged at times to resort to other remedies in malarial fevers, and some competent observers have strongly recommended phenacetine for that purpose. Dr. John V. Shoemaker, in his work on "Materia Medica, Pharmacology and Therapeutics," Vol. 2, states that, “Given several hours before the time of the paraoxysm of itermittent fever it prevents the chill." Other au.thors have furnished equally satisfactory evidence of its efficacy as an antiperiodic. Dr. James Johnston, who has had large experience with the pernicious malarial fevers of Africa, in his interesting work entitled "Realty


Romance in South Central Africa," recommends pnenacetine and sulfonal as among the most valuable contents of a medicine chest for Central Africa. With regard to the use of these remedies in fevers he states that phenacetine is both safe and effective in 5 to 10 grain doses; "that it acts like a charm soothing and quieting the nerves, and producing a feeling of restfulness that is delightful." To obtain the best results from the use of phenacetine in malarial fevers, however the following points should be observed: It should be given in sufficient dose, 10 to 15 grains, and at least four hours before the expected paroxysm When administered in this way phenacetine has proved a very satisfactory antiperiodic which deserves a careful trial.

Recent Views on Sea Sickness.

In a review of this subject by Dr. Skinner (New York Medical Journal) the author comes to the following conclusions:

1. The principal symptoms of naupathia result from the lowering of the patient's arterial blood pressure. This is a condition sine qua non of their development.

2. Seasickness in a person otherwise healthy and not too aged is promptly curable in the vast majority of cases.

3. Even in aged persons, or in persons having certain affections of the circulatory apparatus, there is often amelioration of the general condition by the employment of the new method of treatment.

4. The treatment consists in the hypodermic injection of from half a milligramme of atropine sulphate, associated with a milligramme of strychnine sulphate (or nitrate) dissolved in a cubic centimetre of distilled mint water.

5. The administration of these eminently toxic substances demands a great degree of attention, prudence, and supervision on the part of the physician, who alone should be the judge of the opportunity of their administration and of their dose in each individual case. Given at proper times and in suitable doses, however, no harm whatever will follow their administration.

6. The sympathetic nervous system plays a preponderating role in the causation of naupathia.

7. Naupathia, or seasicknessman affection without known anatomical lesions, and of which the predominant symptoms have their origin in the nervous system, and especially in the sympathetic or ganglionic nervous systemought to be regarded as a neurosis of the sympathetic.

8. This neurosis may recur during the course of a long voyage, but each attack is almost always amenable to the same treatment.

Phenacetine in Malarial Affections

While quinine has been regarded as our most valuable remedy in malarial diseases there is not an inconsiderable

Lotsil is a compound of Thymol-Acetanilide, recrystalized and purified by an improved process, and combined with Citrate of Caffeine, Mono Bromide of Camphor, and Sodium Bicarb; the formula for Lotsil accompanies each package.



ous and vascular systems. The action upon the circulatory system is a peculiar one, and in surgical cases where I have administered, it seems to be a valuable addition to our armamentarium." Kola owes its therapeutic action to caffeine, theobromine, and a principle peculiar to itself, called kolanine. Its stimulating and sustaining effects on the nervous system are more prompt, powerful and of longer duration than that of caffeine alone. It is also superior to coca as a cerebro-spinal stimulant, with none of the objections which so frequently follow the continued use of the latter. Stearns's Kola Cordial is to be recommended to those whose work subjects them to excessive mental or physical exhaustion.

Messrs. Frederick Stearns & Co. will gladly mail on enquiry samples and literature, or will forward an original package to those physicians who are willing to assume the express charges.

“When in doubt Operate."

The silly and ignorant crusade against what people are pleased to call vivisection seems to be joining hands with an

more silly and ignorant attack on life-saving surgery. To show the depths to which it is possible to descend, the


aphorism, “When in doubt, operate" has been twisted from its meaning, and paraded before the publir as an illustration of the awful hankering after operation which is supposed to permeate and degrade the surgical mind. It would be difficulte to imagine a greater perversion of truth than is conveyed in the suggestion that, in such case of doubt as is there meant, the operation would be undertaken for the surgeon's Instruction rather than for the patient's good. In case of hernia there can be no more life-saving rule than this of operating, if there is any doubt as to whether it may not be strangulated. It was an aphorism derived from experience long before operations had the safety now given them by antiseptics; how much more should it hold true now. To give the patient “the benefit of the doubt" means to give him the benefit of the operation, and none but those who know nothing of the subject could have founded on the phase an argument against the tendencies of modern surgery.-Brit. Med. Jour.


KOLA CORDIAL.-Being convinced of kola as a tonic stimulant, and being desirous of presenting a preparation which should contain the active medicinal principles of the drug, yet free from its acrid and bitter taste, Messrs. Frederick Stearns & Co., of Detroit, Mich., after long study and experimental investigations have, by an original process, produced a preparation, “Stearns' Kola Cordial,” which is one-fourth the fluid extract strength, and is palatable and delicious in taste. It has been tested in several large hospitals, and in the private practice of many prominent physicians.

Dr. E. B. Smith, of Detroit, Mich., in speaking of the preparation says: “Kola cordial in my hands has supplied a great want. It seems to be a systemic tonic, acting especially upon the nerv

Liquor Sedans

This I find to be a utero-ovarian sedative and arodyne of exceptional value, as in my hands it has produced the most brilliant and flattering results, far exceeding my most sanguine expectations.

Mrs. W., aet. 44 years, and approaching the menopause; very anaemic, thin, and of a nervous temperament; much anorexia at times; habitually constipated; complains often of headache and palpitation, with frequent but scanty micturition; menstruation very irregular, returning every three to five weeks, and lasting from two to four days; flow small in amount and nearly colorless; attended with violent pains in the lumbar region, groins, with general tenderress over the hypogastric region; no organic lesion of the heart, simply functional as a result of other lesions.

Upon examination, I detected retro.. version of the uterus of the second degree, and a profuse leucorrhoea. Had previously almost exhausted the materia medica in seeking a remedy for her relief; had given fluid extract viburnum prunifolium, cannabis Indicae, etc. As a dernier ressort, I ordered Liquor Sedans, one drachm four times a day, to be continued during menstrual


Mellin's Food






SAN FRANCISCO, July 2nd, 1894.

Dear Sirs:– Mellin's Food was selected for use in the Emergency Hospital at the California Midwinter
Exposition on account of its well-known superior qualities as a food for invalids and the delicately sick.

I am pleased to inform you that it has been in constant use during the entire time of the Fair, and has always
given such complete satisfaction that no other prepared food was needed in the Hospital.

Yours truly,
(Signed) Martin REGENSBURGER, M.D.

Medical Director in Chief.
A liberal sample bottle of MELLIN'S FOOD, sufficient for

trial, will be sent free to any physician requesting it.
DOLIBER-GOODALE CO., 291 Atlantic Avenue, Boston, Mass.

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RECONSTRUCTIVE, DIGESTIVE, ALTERATIVE, for Lung, Bronchial, and all wasting diseases: and intestinal disorders at any period of life.





"IT PAYS TO PRESCRIBE THE BEST." Practiciny Physicians who have never tested ('ODLIVER GLYCERINE will get a $1.00 bottle by filling out blank and paying express delivery charges. NAME




5 5


Dr. Geo. W. Moody, of Huron, S. D., is dead.
Dr. Robert Atkinson is the new coroner of St. Louis.
Prof. Helmholtz, of Berlin, died recently at the age of 73.
Dr. J. L. Short, of Rolla, Mo., has been elected to the legislature.

Dr. J. W. Islaub, of St. Joseph, was elected coroner of Buchanan county on November 8th.

Dr. S. G. Gant, the rectal surgeon of Kansas City, made St. Joseph a visit recently, the guest of Dr. Daniel Morton.

Professor Leyden, the famous Berlin physician, received $5000, according to German papers, for his first visit to the sick Russian Emperor.

A Physician to be Trustee of the Boston Public Library.--Dro Henry P. Bowditch has been appointed by the mayor to be a trustee of the Boston Public Library.

Dudley Sharpe Reynolds, Jr., M, D., son of Dr. Dudley Reynolds, of Louisville; born at Louisville, February 20, 1873, died from the accidental discharge of a pistol at Collinsville, II., October 22, 1894.

Dr. Roux has received from President Casimir-Perier the congratulations of the government and the Cross of Commander of the Legion of Honor, in recognition of his work upon the serum treatment of diphtheria.

Dr. Reid Alexander, of Topeka, Kansas, died on October 8th, of perforation of the bowel, at the age of thirty-three years. At the time of his death Dr. Alexander was the president of the Topeka Academy of Medicine and Surgery.

Dr. N. S. Davis, of the North Western University of Chicago, has been honored by the endowment of a professorship by Mr. Wm. Deering, who has donated $50.000 for this purpose. The venerable father of the American Medical As-sociation will be a credit to Mr. Deering who has so generously honored the doctor and the institution he represents.--Columbus Medical Journal.

Dr. Thomas Garvey, ambulance surgeon to the Harlem Hospital, New York city, came very near losing his life recently, while removing a desperate patient to the hospital for treatment. The man who was partially intoxicated, and suffering from a dislocation of the humerus, drew a pistol and fired on his surgeon, while they were in close quarters in the removal wagon. The bullet took effect in the right shoulder of Dr. Garvey, causing a painful but not serious wound.

Dr. Edgar B. Forsee died in St. Joseph November 4th, at the age of 71 years. Dr. Forsee was an old resident of this city and was well known and liked by all. He was born in Scott county, Ky., July 5, 1823. He graduated from the Louisville Medical University in 1848, locating in St. Louis in 1850, and practiced medicine there and in Florissant, St. Louis county, until 1856, when he moved to this city, where he had for many years a large practice, in which he was very successful. Dr. Forsee leaves a mosť devoted wife who after forty years of companionship will find it hard to tie up the broken threads and take up her life without him.

* Peace which he loved in life, did lend
“ Her hand to bring him to his end."

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