aged twenty-one years, took 1 drop every hour till he had taken eight doses, and then he took a teaspoonful; 9, P. P. Wells, M.D., Amer. Hom. Rev., vol., vi, p. 268, effects of aroma, and U. S. Med. and Surg. Journ., vol. iv, p. 330, a proving, dose not mentioned (symptom 138); 10, same, Amer. Hom. Rev., vol. iv, p. 385, a girl, aged fifteen years, stripped outside bark from the young and tender shoots, and then after writing letters on stalks with a pin, moistened these with saliva, which was rubbed on them with the finger, this was repeated many times, and the juice was thus conveyed to the mouth; 11, same, effects on a boy, of eating the seeds; 12, W. Williamson, M.D., U. S. Journ. of Hom., vol. ii, p. 668, some little boys smoked the stems like segars; 13, Hale's New Remedies, third edition, a résumé; (15 to 17, from Dr. Giraud, Thesis, Paris, 1875); 15, effects of the bark on Dr. Hettet; 16, Dr. Robert, who published the first work on Ailanthus in dysentery, experimented on himself with the infusion, see Archives de Navale, 1874; 17, Dr. Geraud, took two spoonfuls of an infusion.

General malaise, sensation of feebleness, and dimness of vision and nausea,.-He found it extremely bitter, causing nausea, sometimes vomiting. After an hour there was very notable diminution of the pulse, of about 10 beats, which persisted for half an hour, after which it rose and became more frequent than normal,.-After a quarter of an hour there was nausea, accompanied by anguish, similar to that caused by Ipecac. Sensation of tightness in the temples. All these symptoms increased after half an hour to vomiting; the pulse had increased from 68 to 76, temperature from 37.2° to 37.32. After this he experienced a peculiar sensation of emptiness in the stomach. Pulse 80. Temperature 37.7°. This was followed by a fall of the pulse to 64, and a sensation of coldness over the whole body. After a few hours there was colic, followed by a soft stool. In another experiment, he took an infusion, pulse 78. There was no nausea; after three-quarters of an hour, pulse 70, and a sensation of coldness; the pulse rose to 76. After four hours some colic and soft stool,".

ANTIMON. ET POTASS. TART.

Authority. 67, Dr. Molin, Des Specifiques en Médecine, Paris, 1847 (Brit. Journ., vol. vi, 1858, p. 118).

Observation 1.-Being in a good state of health, my pulse beating 64 per minute, I took at 8 A.M., before breakfast, 5 milligrams of Tartar emetic in water. This dose was repeated for five days without perceptible effect. The sixth day I felt nothing until 4 P.M. The respiration then appeared to me a little less free. Feeling no further effects, and my appetite continuing good, I took on going to bed about 9 o'clock, a dose of 1 centigram. The night was passed in a restless manner, and the sleep interrupted by a fatiguing heat; I felt necessitated to drink several times; the respiration was slightly impeded; on rising, general uneasiness, weariness, similar to what follows a febrile fit, the mouth clammy. I took at 8 o'clock in the morning, 1 centigram. No appetite; a simple soup for breakfast without relish. All the day I was in the same state. About 5 P.M., greater uneasiness, especially about the epigastric region; nausea ; desire to vomit, but without result; respiration more impeded; short dry cough, pretty frequent; great thirst; heat in the head; white tongue; drinks appear always too sweet; clammy mouth; two loose evacuations during

the day; palpitation of the heart; bruised feeling and general weariness, compelling me to go to bed at 8 o'clock. The ear applied to the chest gave evidence of nothing abnormal, except that the respiration appeared much too rough. At 9 o'clock I took another dose of 5 milligrams. Agitated sleep, difficult respiration, feeling of pressure on the chest during sleep. At 5 A.M., I was awakened by a violent rigor, it lasted twenty minutes, and was followed by heat; the pulse, which had been little affected during the two previous days, increased to 78, was full and strong; skin hot; face red; thirst urgent; heat in the head; pretty strong palpitation of the heart; slight burning at the stomach; fulness and inclination to vomit; respiration very much impeded; feeling of pressure and constriction of the chest; cough frequent, and a little moister; on auscultation, the respiration appeared rougher than the previous evening, and deep inspiration was accompanied by slight pain under the left nipple. Night very agitated; nightmare; disagreeable dreams. I felt much the same in the morning as I had the previous day, but deemed it advisable not to carry the experiment further. During the subsequent days, the following symptoms occurred. The tenth day no stool; towards evening, pulse 72; respiration somewhat less difficult; cough the same; hardly any pain in the side; great thirst; a good deal of uneasiness; no inclination to vomit; night, a little less restless. The eleventh day, a little less roughness of respiration on auscultation; cessation of the pain; pulse nearly normal; skin still hot; thirst less; uneasiness diminished; appetite in part returned; respiration still obstructed; cough a little less; the night more tranquil. Twelfth day, appetite; breathing nearly free; the cough continues; still a little uneasiness; scarcely any thirst; tranquil night. The symptoms continued to diminish the subsequent days, so that by the eighteenth there remained no trace of indisposition, except slight cough, which persisted some time longer. Not being sufficiently edified by this single experiment, three months subsequently, I commenced another.

Observation 2.-During eight days, I took each morning, 5 milligrams of Tartar emetic, without feeling anything. The ninth day, at 8 P.M., I took another dose of 1 centigram; night somewhat disturbed; the respiration appeared somewhat less free, but that was not very distinct. The tenth day, on rising, a little weariness; I again took 1 centigram. During the day I had some uneasiness; mouth clammy; little appetite; breathing impeded. About 10 P.M., I took another dose of 5 milligrams; sleep very disturbed, and towards morning uneasiness, especially at the epigastrium; some nausea; loss of appetite; respiration impeded; a watery stool at night; great fatigue; urgent thirst. From the morning of the eighth day the cough appeared, and went on increasing; it is short, frequent, and painful; auscultation gave no results. At 9 A.M., 1 centigram was taken. In the course of the day, rigor, which lasted half an hour, with burning in the head and beating of the heart; thirst; inclination to vomit; pulse 80, strong; skin hot; cough dry and painful; considerable difficulty of respiration; sensation of weight on the chest; auscultation shows rough respiratory sounds; general bruised feeling. This state continued all day and night, which was very much disturbed by strange and fatiguing dreams. There were two watery stools during the twenty-four hours. The following days the symptoms declined, but more slowly than the first time, so that by the twenty-fifth day I had not entirely recovered my health,"7.

APIUM GRAVEOLENS.

Authorities. 2, L. W. Berridge, M.D., Amer. Journ. of Hom. Mat. Med., vol. viii, 1874, p. 126, effects on Miss. from eating celery; 3, W. J. Ramsden, Brit. Med. Journ. (Hom. World, 1878, p. 343), a patient ate a whole stick of the vegetable.

During the following day and night, a most obstinate retention of the urine, which could only be relieved by the catheter,.-Inability to sit still or lie still in bed, from feeling of "fidgets;" cannot keep mind from thinking,'.

BELLADONNA.

Authority. 286, Drs. Flechner, Frankel, and Schneller, Zeit. der k. k. Gesel. der Erzte zu Wien, 1847, p. 97, a proving beginning with 2 drops of the tincture, and increasing irregularly to 130 drops.

A dose of 2 to 30 drops, especially the latter, caused slight dryness of the mouth and nose, insipid taste, yellowish fur on the tongue, diminished appetite, dulness in the frontal region, roaring in the ears, weakness of vision, with normal, rather contracted pupils; in one person, in addition, pain in the small of the back; in another person stitches in the region of the shoulder, and in the left side in the region of the false ribs. From 35 to 60 drops the above-mentioned symptoms in the mouth and fauces increased to a distressing degree. There was burning in the hard palate and throat, with great redness of these parts, the voice became hoarse, the intestines distended by gas and painful. The head became dull, there were vertigo, sleepiness, and frequent yawning, restless sleep. In two provers there were also transient stitches in the region of the heart, tearing pain in the head, in the region of the shoulders, and in the feet. These symptoms continued in a less degree, even on the following day when nothing was taken. After doses of 65 to 130 drops, the above-mentioned symp toms increased, with the exception of transient pains; the eyes became especially affected, there was foggy vision with vertigo, the eyes seemed covered with a veil, reading was very difficult, the conjunctiva was injected, the pupils in one case, from 110 drops, dilated. Lastly it was noticed that the urinary organs became affected, so that micturition was accomplished with great straining and difficulty. On the same day in which one prover took 110 drops, an experiment was made with an external application to the conjunctiva; a few drops were rubbed into the upper lid, and some trickled into the inner canthus. About a quarter of an hour afterwards there was some dilatation of the pupil, which increased so that after two hours there was scarcely a line of iris to be seen. The margins of the lids became red, the conjunctiva slightly injected; even the pupil of the other eye was somewhat dilated. The iris of the right eye was sluggish in action, vision was very weak, and the eyes seemed veiled. On the next day, the right pupil was still considerably dilated and vision very much restricted, especially in the open air. At the same time the eye was drawn somewhat upward and outward. On the third day vision was only somewhat weak, the pupil remained dilated for several days. The following were the chief observations from twenty-one provings with three different preparations: the mucous membrane of the mouth and fauces was first affected; thence the affection extended upward to the mucous membrane of the nose and frontal sinuses, and partly to the conjunctiva and Eustachian tube, then

downward into the larynx, then from the throat into the stomach and intestinal canal. This affection consisted essentially of dryness of the parts, for example, dryness of the whitely coated tongue, pasty taste, diminished appetite, desire for liquids without thirst, scraping in the throat, difficulty of swallowing, hoarseness, difficult speech, sneezing, nausea, inclination to vomit, pressure in the stomach, diminished stools, increased gas in the intestines. As objective symptoms, there were dark redness and swelling of the mucous membrane as far as could be seen. A second sphere of action of Belladonna seemed to be the brain. The symptoms consisted of vertigo, pressing and aching pain in the head, reeling and slight stupefaction, sleepiness; the sleep, however, was restless and disturbed by vivid dreams. There were general prostration, general ill-humor, and disinclination to mental work. Dulness and confusion of the head lasted a long time. Of the two extracts, the alcoholic and the aqueous acted in a greater degree upon the brain than the extract of the Austrian Pharmacopoeia; with the former it was especially noticed that with the increase of the symptoms of the mouth and fauces the head symptoms diminished. There was noticed an antagonism between the two preparations. The disturbance of vision. began with a slight degree of weakness and fogginess, sensitiveness to light, and progressed to illusions of vision, flickering and visions of colors, a feeling of pressure in the eyeball, increasing to a high degree of weakness of vision, with injection of the conjunctiva, increased lachrymation and dilated pupils. From the external application of the above mentioned, the symptoms were more pronounced; the pupils were extremely dilated, the iris less sensitive, and the eye turned upward and outward. Especially interesting was the action of Belladonna upon the urinary organs. Without calling particular attention to the nocturnal erections, produced by the smaller doses, there was noticed relaxation of the urinary organs in such a way, that there was frequent desire to urinate, with inability to pass urine except by great pressure, and then only guttatim. The action of Belladonna on the skin was increased warmth, amounting even to glowing heat of the face, turgor, and a very deep-red color, even a cherry red. In one person, 4 grains of the Austrian extract caused red circumscribed spots on the face. In the vascular system in general there was a feeling of chilliness, coldness of the extremities, alternating with heat and increased transpiration, accelerated pulse, and palpitation,286.

Calcium chloride.

CALCAREA MURIATICA.

Authority. August Wimmer, M.D., "The Salt-waters of Kreuznach," translated by the author, Kreuznach, 1878.

I made these experiments first in October, 1876, in a period of three weeks. In the first seven days, I determined the quantity of the oxidation of my body; I determined, therefore, daily the weight of my body, farther the weight of the solids and fluids which I partook of, and the weight of elimination of the urine, of the dejecture, and by the skin and the lungs; the latter, by comparative calculation of the excretion of urine and of dejecture with that of the body.

Twice a day, in the morning at 8 o'clock and in the evening at 6 o'clock, the quantity and quality, the reaction and specific weight of the urine were determined and analyzed, after the well-known methods of "Titrirung," of

Neubauer and Vogel, into the constituents of urea, uric acid, sulphuric acid, phosphoric acid, and chlorine, with the utmost carefulness, and with the observance of all precautionary measures.

The temperature, the state of the barometer, the direction of the wind,, weather, the state of the health, and the functions of the skin, were at the same time carefully observed.

In the period of seven days following that of the preliminary examination, I took daily 0.5 gram, and in the seven days following the second period 1 gram Calcium chloride, dissolved in a glass of spring-water, and I continued the daily determination of the weight of my body, of the reception and of the elimination, as well as the analysis of my urine, and observed as much as possible the same relations with regard to the movements of the body and to the food as during the preliminary examination. Only the determination of solid food was too difficult, and as my mode of living for many years has been the same daily with regard to the quantity of vegetables, bread, sugar, etc., I only weighed my daily portion of meat, because meat essentially influences the secretion of urea and uric. acid. The results of the three weeks' series of examination were so abundantly convincing that a second series would not then have been necessary. However I preferred making a second one of a longer duration, to guard against the imputation of a premature judgment. The execution of the same was not possible until April, 1877.

I found no reason to deviate from the method followed in the first series of examination, and preceded it also by a preliminary examination of seven days. In the first four days I determined the weight of solids and fluids; only later, the daily quantity of the meat and the fluids. I separated the latter from the fat, and took it partly raw, chopped, partly slightly cooked. A change was made of the different kinds of meat, beef, pork, and veal. For the first breakfast I took tea and white bread without butter; for the second, bread and butter; for dinner, meat, soup, vegetables, and raw or cooked meat, with only a few potatoes; in the afternoon, a cup of coffee, and in the evening, tea with bread, butter, and meat. I give in the following the results of the second four weeks' examination, made in April, 1877, in calculated average amounts, because the statement of the daily results of examination would take too large a space, and the average amounts are fully sufficient for judging the matter.

I only add that the results of the second series of examinations are, fully identical in regard to the essential points with those obtained by the first series of examinations, and that I am fifty-seven years of age.