no urging to stool; pain increased till 1 P.M., just before dinner, when a soft stool occurred and the pain ceased (third day),'.-After a stool, with much pressing, sense of fulness in the anus, in the evening (fifth day),'.

Stool. (Of a constipated habit for years, the stools now became soft, and remained so until after the proving, when again constipation as before),.-First a hard, then a mushy, thin stool, with protrusion of the anus, at 10 P.M. (first day),'.-[60.] Slight inclination to stool, as if diarrhoea would set in, while walking on the street, towards evening (third day),'.Thin stool, with quick and violent urging, as if diarrhoea would set in (fourth day),'.—All stools but one on the fourth day, since the proving commenced, occurred in the afternoon or evening (fifth day),'.-Frequent stools, followed by slight colic (first day),2.-Stool more frequent and softer. Continues two days after stopping,".-Stool no longer daily, but every other day (eighth day),3.

Urinary Organs.-Pressing pain in region of left kidney, as if the urine had been retained too long; worse while sitting; pressure does not aggravate, but rather relieves it, but it gets worse afterwards. Frequent urging to urinate; aching in the bladder. Pain in kidney very marked towards evening (fourth day). While sitting, still some pain in left kidney (fifth day),.-Pressing in the bladder, as if it were full of urine (first day),.-Stitches through the bladder and painful weakness (tenth day),3. -Stitches through the urethra to the glans (first day),.-[70.] Increased urging to urinate, he passes more, but not often, in the evening (third day),'. -Frequent urination; the bladder feels full, and yet but little urine passes (thirteenth day),.-Frequent urination during the day; frequent urging and scanty discharge (first day). Copious urination (second day). Urging to urinate and scanty discharge remain (third day),'.

Sexual Organs.-Erections every morning, but none in the evening and at night, even none from excitation (eighth to eleventh day),'.Pain in uterus or region of the bladder (fifth day),.—In the evening she went to church, and walked home rapidly, when the menses reappeared, as they had done often after exertion; it was the seventh day since they had commenced, and since thirty-six hours there had been nothing visible. The occurrence of the menstrual flow may be attributed to the medicine, for it is of a different character than that which usually occurs after exertion, it is more like clear blood (second day). Menses continue, but less copious and watery (fourth day),.-The proving was commenced a day after her catamenia had ceased; the following menstrual period came several days sooner,".

Chest.-After sitting awhile, " congestion" in right side of chest (after four hours),Aching along the edge of the ribs and the diaphragm (fourth day),.-On bending the body forward, while sitting, flying stitches from the middle of the chest in the direction of both shoulders (thirteenth day),-[80.] Pressing in the suprasternal fossa (first day),.-Stitches in right chest in the region of the nipple, running deep in; worse from taking a deep breath, disappearing while walking in the open air (seventh day),.-Fleeting stitches on the inner side of the collar-bone, on entering the room, after walking in the open air (seventh day),3.

Heart.-Frequent painful pressure in the cardiac region, and low down in the left chest, occurring at intervals (fourth day),'.—At 2 A.M., pain in the cardiac region (fifth night),.

Back.-Pain in left trapezius muscle, as from lying on it too long; worse when turning the head to the left (fifth day),.

Neck and Back.-Sensation as if he were getting a stiff neck, especially on both sides, above the first dorsal vertebræ; immediately after in the lower portion of the scapula, and at the same elevation in the spinal column, a pressing pain as if a dull object were being slowly pressed against the spine. This is followed by a repetition of the stiffness in neck (first day),.-Very painful contraction of several muscles on the right side of the neck, felt several times since the proving commenced (seventh day),'.Painful drawing in the neck and shoulders and down the left arm, of short duration (first day),.--Weak back in the morning (sixth day),.-[90.] In the afternoon dull pressing backache, as from sitting up stiffly too long (eighth day),.-Sat three hours in church, in the evening, listening to a tedious sermon and dull exercises, which gave her a pain in the back, but no headache. This, another time, would have failed to come (fifth day),. -During the night pain in the back across the hips, perhaps because the child was restless. She was anxious about it, but not impatient (fifth night),.

Extremities.-For about an hour aching through the limbs, as if beaten, with a feeling as if the menses would appear, in the afternoon; both symptoms diminished in the evening, without entirely disappearing (first day). The menses did not appear,1.

12

Superior Extremities. —As if beaten in the muscles of both arms and shoulders to the elbows (second day),".-Painful drawing in the right shoulder, on returning to the room, after walking in the open air (seventh day),.-Sensation in left arm as if it were "going to sleep" (third day),'. -Rheumatic pains in the right shoulder, in the evening (eighth day),. A few lightning-like stitches in the right shoulder, almost making him scream (seventh day),.-Tickling in the right shoulder (after ten minutes),.-[100.] Left arm still feels as if "gone to sleep," at 11 A.M., lasts half an hour (fourth day),'.-The numbness in arm passed off in the evening (fourth day),'.—The right arm and hand often get numb in the night (eighth to eleventh day),'.-Slight numbness in the right forearm, extending to the fingers, from 3 P.M., seventh day, until evening of the elev enth,".-Drawing pain in left forearm, as if lame, more on the radial side, disappearing in the open air (seventh day),.-Sudden twitching in the right wrist and metacarpal bones (third day),.-Pain in right wrist, extending into the forearm (after four hours),2.-Severe pain again deep in the left hand, burning and boring, as if shattered; it wakes him (second night),'.-While sitting still, constant painless twitching, which crooks the fingers, particularly the index finger, until 12 o'clock (fourth day),'.-Short, violent, stinging pains in the metacarpal bones and thumb of the left hand (fifth day),'. -[110] Sudden stinging pain in the metacarpal bone of the middle finger on the left hand, at noon (first day),'.—Stitches in the fingers, first left then right (first day),'.

Inferior Extremities.-Dull gnawing pain in left hip (after one hour and a half), 2-Twitching pain in left hip joint, during the morning (fifth day),.--On the following days she has a sensation as if the articulating ends of the thigh-bones expanded or were pressed out of their sockets, especially on the left side; she did not notice it while walking, but when pressing down as if for a stool,2.-Pain above the left knee, extending from there into the chest, in the morning (sixth day),".-Tensive pain in right knee, of short duration (first day),.-Small stitches above the knee, like flea-bites (first day),.-Tearing in the legs, isolated short stitches, as if proceeding from little pimples (first day),'.

Generalities.-Very tired in the evening (thirteenth day),.-[120.] Very tired when walking, he reels on coming into the room, in the evening (third day),'.-Feels heavy, tired in the limbs, inert, and undecided, in the morning (third day),'.—Åversion to making any exertion. She feels as after taking Mercury and afterwards Magnésia, as she has sometimes done, but this may have been caused by the exertion (seventh day),".While walking it seems to him as if he had grown much taller; the feeling recurs repeatedly. The symptom did not return later either in lying down or walking (third day),'.-Towards morning, somewhere in the left side (forgotten because it disappeared on turning), a peculiar pain never experienced before (second night),.-Neuralgic pains in the body, here and there (first day),.-Bellyache before rising, afterwards pain in right temple. At 7.30, while walking, rheumatic pain in right hip. At 9.15 pain in right thumb, then in forefinger, first in right, then in left temple, in right shoulder and arm, then again in right temple. Some pain in small of back, extending over the right thigh, then pain in right wrist, in left hip, right hand, and right lower jaw. After a walk, at noon, pain in right temple and right arm. The pains change place so quickly, and at times are so transient, they are hard to describe. The pain returns oftenest to the temple, and remains there longer than anywhere else (third day),.—At 2.30 P.M., violent throbbing throughout the body, preventing sleep for a long time (after seven hours and a half, second day),.-Feels worse in the afternoon (third day),'.-Motion seemed to aggravate all symptoms (fourth day),'.—[130.] Nearly all symptoms appeared towards evening, or were more perceptible then (thirteenth day),.

Skin. Small pimples on various places, particularly back of the left ear, painfully sore (sixth day),'.-Itching pimples in the whiskers, left side, in the evening (seventh day),'.-In the third week a slowly ripening pimple above the tip of the nose, which bled for a long time, after the pus was squeezed out,'.-A deepseated pimple on the right cheek near the wing of the nose, red, not painful (does not come to a head), (seventh day),.-Pimple on the back portion of the right zygoma (eleventh day); one in the same place on the left zygoma (twelfth day),3.—A pimple on the right side of the neck, which has been there several days, begins to itch and burn. A pimple beneath the right eyebrow, near the canthus, burns and bites when touched (eighth day),3.—Ă vesicle on the inside of the under lip near the left corner (sixth day),.-Several small vesicles, clear as water, on the edge of the lower lids (seventh day),'.--Between 2 and 3 P.M., something similar to a fleabite on the right side above the lip, also on left nostril, and on various places on the body and head (after seven hours, second day),.--[140.] Felt a burning and itching on a small spot on the right side of the face, in the morning (third day),'.-Burning and itching on a spot below the point of the right shoulderblade, also on various places on the right thigh and leg (fifth day),'.-Burning and itching in a small spot in the left groin, in the evening (third day),.-Crawling, as of fleas, and itching on various parts of the body, on the back, arms, abdomen, thighs, and ankles,".-At 7 A.M. crawling over the entire back and thighs, as from fleas, accompanied by itching; disappears when scratching, but soon reappears in a neighboring place (second day). With thirty-six hours it had become very troublesome, lasted during the entire proving and two days after stopping the drug. One day observed small elevations here and there like a nettlerash, red on a base whiter than the skin,'.-Itching over the whole body, while undressing, in the evening (sixth day),'.—At 1 A.M.,

itching above the left zygoma, about the eye and nostril, later also in right side of face, near the eye, and on the side of the head (third day),.—Itching on the inner side of the left ankle, on the inner side of the right thigh, on the right elbow, and more on the back of the neck, in the left eyebrow, and in the left arm (after ten minutes),6.

Sleep.-Drowsy and lazy in the evening (fifth day). The drowsiness and fatigue return later every evening; he is very much exhausted, disinclined to work; he lies down and goes to sleep if he can (sixth day),'.Unusually sleepy in the evening, while riding in the carriage and seeing patients, not after coming home (second day),'.-[150.] At 2 P.M. she lies down, falls asleep, and wakes with a start. The head, which ached in the forenoon, is better, and the hip no longer pains. She slept another half hour before dusk, which completely relieved the headache (fifth day),.— At 3 P.M. overpowering sleepiness, lasting for one hour, passes off with pain in left temple. With this the symptoms closed (fourth day),.-For nearly a week he has had the same kind of a dream every night, he always remembers it in the morning, of houses, buildings, in which he was or beside which he stood, often as if he stood at a window, walked up and down staircases, through various apartments, etc. (seventh day),'.

PERSICA.

Authority. 4, Dr. Demeures, Journ. de la Soc. Gall., vol. iv, p. 108, effects of a drop of the tincture.

The gums are swollen and bleed on the least suction, without pain,.A quarter of an hour afterwards, while lying on the grass, pain in the cartilage of the last true rib, near the sternum, felt especially during inspiration, less on touching, like the pain of a blow,.-[40.] Immediately, numbness of the fingers,.-Twenty-four hours after, numbness of the fingers when writing; the eyes are tired and are filled with tears when reading,'.— Pain in the right thumb, at the extremity of the great flexor muscle. This pain is not felt when touching the part, nor when writing,'.

PETROLEUM.

Authorities. 23, G. W. Haile, M.D., Cincin. Journ. of Med., May, 1867, p. 300, Mary, aged eighteen months, drank an indefinite quantity; 24, Dr. O. Lassar, Virchow's Archiv, Jan. 1878 (Lond. Med. Rec., 1878, p. 163), effects of inunction.

Rolling its eyes up occasionally (after fifteen minutes),".-Pupils slightly contracted (after fifteen minutes),23.-Breath smelt very strongly of the oil (after fifteen minutes),".-A kind of spasmodic cough (after fifteen minutes), 23-Very hard convulsion (soon),23-The urine had been highly albuminous, and contained "hyalin and granular cylinders." At the necropsy, the body was extremely edematous, and the epidermis in places was raised in little blebs; dissection showed dropsy of the cavities and oedema of the lungs, but no lesion of any organ to account for the dropsy, the kidneys being perfectly normal in all respects. "The most scrupulous histological investigation failed to find a trace of interstitial growth, proliferation of nuclei, amyloid degeneration, or more than traces of fatty degeneration of the epithelium." On inquiry, it turned out that this man

had dated the commencement of his illness from an extensive inunction of his body with Petroleum, which about four months before his death, he had employed as a means of relieving himself from scabies. He used the Petroleum for four days, and a week elapsed before he noticed swelling of the feet, which, rapidly increasing, spread over the abdomen and thorax; in the course of a fortnight it disappeared, but returned after eight days, and persisted up till his death. While in hospital, the radial pulse was noted to be small, empty, and of low tension; the blood-corpuscles were few, but their relative proportions were normal. Temperature was normal. Histological examination of the skin showed localized areas of inflammation; along the veins and lymphatics a small-celled growth existed, and in all the layers of the cutis there was a widely distributed nuclear proliferation, Much inclined to sleep (after fifteen minutes), 23.

PHOSPHORUS.

Authorities. 233, Brit. Med. Journ., 1877 (2), p. 422, a young woman, in the seventh month of pregnancy, took a small quantity of Phos. paste several times; 234, W. T. Martin, M.D., ibid., 1878 (1), p. 478, fatal poisoning of a man, aged thirty-one years, by the paste; 235, F. W. Willmore, ibid., p. 564, two girls, aged sixteen and fourteen years, took between them about ounce of the paste.

Head.-Severe frontal headache,2

235

Eye.-Eyelids closed, pupils dilated and insensible to light,234. Mouth.-Tongue coated with blackish fur,234.-The breath and vomited matters smelt strongly of the poison,235.

Throat. Swallowing attended with difficulty and pain,235.

Stomach.-Vomiting, 25-She suffered from severe pain and vomiting, and died in about forty-eight hours, having been previously delivered of a stillborn child,233.

Abdomen. Abdomen tympanitic,234. Whole abdominal region greatly distended, painful, and tender,25-[3930.] Abdomen and right hypochondrium slightly painful on pressure; area of hepatic dulness not increased, diminished if anything, 24.

Stool.-Bowels constipated,

234

Respiratory Organs.-Respiration 48, without stertor,234.

Pulse.-Pulse 88, weak,234.-Pulse thready and easily compressed, in the eldest girl 135, in the younger 98,235.

Generalities. -Convulsions (eldest),235.—Weak, anxious, and depressed,234.

Skin.-Skin and conjunctivæ of a distinct yellow tinge,234 235 Sleep.-Drowsiness (eldest), 25.-Appeared drowsy but complained of sleeplessness,234.

Authority. John H. Henry, M.D., Amer. Obs., vol. xv, 1878, p. 16, most of the symptoms were produced on myself by taking the P. for five days.

Mind.-Sad thoughts, desires to sleep.