ulous. It covered the whole body below the head. I staid in half an hour, and it was nearly of the temperature of the body.

April 28th. Bathed again, keeping the bath at the same temperature or making it rather higher, and of the same strength in regard to acid. I staid in it half an hour. I still feel no material effects from the bath. Pulse after bathing 76. The only apparent action of the acid is on such animal matters as are unprotected by life, with which it forms an acid

soap.

29th. Bathed again, and continued as before, for half an hour in the bath. To day the bath was hardly as hot as the body. About half an hour after bathing yesterday, I became sensible of an odd sensation about my gums, my jaws, and my teeth.

30th. Bathed again, and staid half an hour in the bath. It was rather warmer than my body. Since yesterday I have been sensible of some uneasiness in my throat on swallowing. I feel a disposition to salivation at times, but I am otherwise well. My gums, both above and below, are somewhat reddened. I was for some time disposed to ascribe these effects to imagination, but they have continued all this day, and leave me no doubt of their reality. I am in good health.

May 1st. Since yesterday I have felt some pain in my throat, especially on swallowing. This pain seems to follow the course of the esophagus. During the whole of this forenoon, I had a sense of burning over the roof of my mouth and down the gullet. This sensation is like what arises from having chewed an acrid vegetable substance; and is so unpleasant, that unless it leaves me by to-morrow, I shall bathe no more. To-day I bathed as usual, staying in the bath for half an hour. It has been to-day, and is, in general, so acid as to make my skin smart a good deal in many places. 2d. My mouth, etc., though not in the least ulcerated, is somewhat painful. I am sufficiently convinced of the great power of this bath, and shall bathe no more. My digestion is improved, and I feel that my liver, unclogged by disease, is doing its office with facility, which for some time past has not been the case with me.

6th. I have not bathed again, but I still feel the effects of the bath in my mouth. My appetite is now good, and I sleep with tranquillity, which I had not done of late. With all this, my pulse is quicker than usual, and I am sensible of some degree of languor. It is, however, to be observed, that the weather is very hot, the thermometer being, during the day, in the shade, from 92° to 96° of Fahrenheit.

June 6th. For a fortnight after giving up the bath I was sensible of some of its effects upon my mouth, and my pulse remained too quick. I am now remarkably well. My liver seems to be sound, and I have experienced a happier change than I ever did from Mercury. Mere sponging the skin with Nitro-muriatic acid, sufficiently diluted with water, gives rise to the very same effects with bathing. Fifteen or twenty minutes may be employed in the sponging, though I found that a much less time does produce very material effects. When the bathing or sponging is carried to a considerable extent, and when the system is much under its influence, a sense of weakness comes on occasionally; some nervous irritation and restlessness are felt, a taste of metal (generally compared to that of copper) becomes sensible; a sense of pain occurs in some parts of the palate or mouth, which is not permanent, but comes and soon goes off again. At length little specks or small ulcerations, extending no deeper than the cuticle, are seen on the interior surface of the mouth and over the tongue,

so that some degree of excoriation or rawness is at last produced. This is attended by a considerable discharge of saliva, with an increase of the feeling of lowness or depression. These effects resemble those of Mercury, but they are not the same. The excoriation from the Nitro-muriatic acid never reaches deeper than the cuticle; it never gives rise to fetid ulcerations of any kind, nor does it produce the least offensive smell of the breath nor in the mouth. The effects of it in this way are surprisingly fugitive. At one hour the discharge of saliva may be excessive; the next it will stop, and perhaps suddenly come on again. The excoriations in the mouth generally go away in a day or two if the remedy be discontinued, and appear no more. While the mouth in this way is affected by the acid, the teeth partake of uneasiness; but I never saw this in a considerable degree, nor have I known any injury done to the teeth or their sockets. These last-mentioned effects are seldom met with to the extent that I have described, and need not be excited unless some peculiar circumstances require an unusual power, such as the symptoms of syphilis. I have lately added more and more of the Muriatic acid in proportion to the Nitric, and the effects have proportionately increased. I now make use of equal parts of the acids. It sometimes very suddenly increases the secretion of bile, and this effect may be kept up for a length of time. It increases the perspiration, and often to a great extent. Whether the acid be applied to the inner surface of the stomach, or to the external surface of the body, the effect is the same in kind, though not in degree,3.

NUX MOSCHATA.

Authority. 18, C. G. Mitscherlich, Pharm. Journ., vol. ix, 1849, p. 233, effects of large doses of the volatile oil.

Diarrhoea,.-Increased secretion of urine,18.-Excites the vascular system and the respiratory organs,18.

NUX VOMICA.

Authorities. 70, Lancet, vol. x, 1826, p. 732, a young woman swallowed a pennyworth; 71, John Horan, ibid., 1856 (2), p. 11, a man, aged thirtyfive years, swallowed ounce of the powder.

Looked very excited,".-A strong general tetanic spasm, which was very much increased when an attempt was made to wipe the perspiration from the face,".-Paroxysms from time to time; the patient stretched out her arms, clenched her fists, and threw her head back, whilst at the same time the jaws were firmly closed, the countenance much distorted by the contraction of the muscles, and strongly expressive of agony,.-Bathed in perspiration,"

OCIMUM.

Authority. 2, Mart, Arch. der Pharm., May, 1851, p. 226 (Pharm. Journ., vol. xi, 1852, p. 82), effects of a weak infusion of the entire plant. It is employed in baths, for rheumatism,2.—[20.] It acts as an irritant,2. -Sudorific,.

OCIMUM BASILICUM.

Ocimum basilicum, L.

Authority. M. Peckolt, Archiv der Pharm., May, 1851, p. 226 (Pharm. Journ., vol. xi, 1852, p. 82).

Women mix it with snuff partly on account of its pleasant odor, and partly because it is thought to clear the eyes.

This plant is very much employed in baths as a tonic.

OLEANDER.

Authority. 18, Dr. T. Murray, Indian Med. Gaz., 1877 (Lond. Med. Rec., Feb., 1878, p. 87), R. D., aged thirty-five years, took a strong infusion of 4 ounces of the root for the cure of a Guinea-worm in his left leg, and died on the fifth day.

Insensibility,.-Eyes turned up,.-Stiffness of the muscles of the jaws,18. -Bitter taste in his mouth,18.-Vomiting, 18.-Severe cramps in the abdomen,18-Weak, thready pulse; afterwards barely perceptible pulse,18.[430.] Severe cramps in the extremities,.-Fingers rigid, and the thumbs turned into the palms,.-Convulsive spasms, with cold and clammy skin, and the pulse was barely perceptible,18.-Cold, clammy skin,18.

OPIUM.

p.

Authorities. (351 to 353, from Franklin Scott, Inaug. Diss., Philad., 1803, p. 18); 351, gave Mr. J. A., æt. twenty-three years, 40 drops of tineture; 352, I took 2 grains, rubbed down, with a little water; 353, Mrs. H. took 6 drachms of tincture; 354, Dr. Dufresne, Bib. Hom., vol. i, 1833, p. 227; 355, J. B. Biddle, M.D., South. Med. and Surg. Journ., July, 1851, 427, a woman took 2 fluid ounces of Laudanum; 356, A. Hadden, M.D., Amer. Med. Times, vol. i, 1860, p. 149, Mary McD., æt. twenty-eight years, took a dose of Laudanum; 357, H. J. Horton, M.D., Med. and Surg. Reporter, vol. xv, 1866, p. 225, Mr. E. H., æt. thirty years, took 3 ounces of Opium; 358, same, ibid., vol. xiv, p. 336, a child, two weeks old, took 6 drops of Laudanum; 359, Henry Gibbons, M.D., Pacific Med. and Surg. Journ., 1868, p. 163, Mrs. swallowed a gill of brandy, and immediately after an ounce of Laudanum; 360, J. E. O'Brien, M.D., Chicago Med. Journ., vol. xxvi, 1869, p. 720, Emmy C., æt. two years, swallowed 13 pills of gum Opium, each containing about grain; 361, F. W. Campbell, M.D., Canada Med. Journ., vol. vi, 1870, p. 62, A. B., æt. thirty-two years, took about 2 ounces of Laudanum; 362, J. B. Chaggon, M.D., ibid., p. 409, Mr. A. G. took same quantity; 363, S. W. Morrison, M.D.,, Philad. Med. Times, November, 1875, p. 106, a child, æt. four weeks, took an indefinite amount; 364, J. C. Morse, M.D., Pacific Med. and Surg. Journ., 1876, p. 56, a man swallowed between 40 and 70 grains of Opium; 365, omitted; 366, C. H. Morfit, M.D., Phil. Med. and Surg. Rep., 1877 (2), p. 466, poisoning from swallowing ounce of Laudanum; 367, Wm. T. Plant, M.D., New York Med. Rec., vol. xii, 1877, p. 717, a man, while intoxicated, took 1 ounce of Laudanum, and died; 368, Dr. Janvrin, Amer. Journ. of Obstet., vol. xi, 1877, p. 780, a child, æt. five weeks, took 10 drops of Squibb's liq. Opii. com. ; 369, T. G. Nasmyth, M.B., Edinb. Med.

Journ., December, 1878, p. 505, a woman swallowed about 12 drachms of Laudanum, and died in thirty-six hours; 370, F. A. Southain, Brit. Med. Journ., 1878 (1), p. 824, a man, æt. thirty-eight years, took a quantity of Laudanum; 371, North Carolina Med. Journ., 1879, p. 65, Bettie R., æt. thirty years, swallowed upwards of 13 fluid ounces of officinal tincture of Opium; 372, Dr. Miclucho Maclay, Chemist and Druggist (Nature, vol. xix, 1879, p. 492), observations of Dr. Clouth.

Mind. In the forenoon of the second day her mind was very much disturbed at intervals and by paroxysms; during one of these she would leap out of bed, and, notwithstanding all opposition made by the nurse, would run downstairs and escape from the doors. These exertions would exhaust her strength, and before she could get far would become faint, fall down, and beg to be carried to her bed; she would then be composed for a time, till seized with a second paroxysm. These were repeated several times during the day,--[2300.] Hallucinations,.-The sleep which he had that night was not natural; he passed the night in some jactitation, attended with delirium and frightful dreams,.-Exhilaration of spirits (after forty-five minutes),3 351 352-A sensation which he compared to intoxication (after thirty minutes); had subsided considerably (after sixty minutes),.-The stupor and lethargy were so great that he went to bed at 9 o'clock (after three hours and a quarter), 1. — Stupor," 332 333 360--Stupid, livid, and unable to stand,367.-Unconscious,355 363 368. 5.-Perfect insensibility; he could not be roused in the slightest degree by rough handling or loud shouting (after three hours), 36.--Insensible and snoring loudly (after two hours),[2310.] Deep coma,359 369, etc.

331

Head.--Vertigo (after thirty minutes),.-Vertigo, much worse on trying to walk (after two hours),352-Whenever an attempt was made to walk I staggered a little, and felt as if intoxicated with wine (after five hours), 352-Turgescence in the head (after ten minutes),-Sensations of turgescence in the head (after forty minutes),352.-Pain in the head (after two hours),.-Pain in the head and over the eyes (second morning),352,At 10 A.M. the pain in the head increased, attended with a sensation of throbbing in the brain, which was almost intolerable (second day),552.— First proving: After preparing the 24 cent. trituration, put 1 grain on the tongue. There were no marked symptoms through the day, except a constant sensation of frontal headache, which I attributed to the heat of the day, and not to the Opium. At night I slept badly, and much less than usual. The next morning I took a new dose of the 1st trituration. The frontal malaise increased, the head was heavy, and I experienced loss of energy. That night I slept none at all, but there were no disagreeable symptoms. During the whole time that I remained in bed I had no sensation in the head, but on rising in the morning the malaise returned. Towards 11 A.M. I was seized with vertigo, which seemed to me the precursor of the migraine to which I had been subject for more than twenty years. It disappeared and gave place to a headache, which passed off in about three-quarters of an hour. After this I experienced præcordial anxiety, with pain in the stomach, to which I had formerly been subject with the migraine. I was soon obliged to sit down and rest, and I found myself covered with cold sweat, excessively fatigued, succeeded by nausea. All this, however, was nothing new to me, although I had not suffered from so severe an attack for more than fifteen years, and it was entirely out of proportion to the severity of the head symptoms. These distressing sensations did not last long, and I returned to my house and lay down and rested,354.

Eye.-[2320.] Eyes red (after eighty minutes), 352-Eyes very red (after two hours),353-Eyes glazed, half open, pupils moderately dilated, and immovable (in half an hour),.-Eyes half open and fixed,3-Eyelids closed (after two hours),.-Heaviness over his eyes (after thirty minutes),.-Conjunctive considerably injected (after two hours), -Conjunctivæ insensible,370.-No reflex action was excited by touching the eye itself (after three hours),.-Pupils insensible to light (after seven hours), -[2330.] Pupils very much contracted and insensible to light (after one hour and a half),356; (after three hours),.-Pupils contracted to a point (after ten hours), etc.

355 360

363

Ear.-Ears and back of neck livid (after two hours),361.-Tinnitus aurium (after sixty-five minutes),351.

Nose.-Nose pinched like a cadaver, and could not inspire through it (after three hours and a half), 57.

355

Face.-Face pale (after two hours),33.-Face pale and ghastly (after two hours), 36-Face suffused (after forty minutes),352.--Complexion somewhat cyanotic,370-Lividity of countenance," [2340.] Face and lips swollen and livid (after one hour and a half),356.--Countenance of leaden, deathlike hue,359.-Livid lips," ,359 362.-Lips and tips of ears livid (after three hours), 31-Jaws clenched (after two hours),"

358

Mouth.-Teeth clenched (after two hours),.-Tongue projected, tumefied, and blue (after three hours), 362-Tongue swollen and thrust between the lips, and trembling (after ten hours),300

Throat.-Spasm of the throat,.-Inability to swallow,355.

Stomach. [2350.] No appetite (after three hours), 352-Nausea (after forty-five minutes); increased (after seventy-five minutes),.-Slight nausea (after twenty-five minutes),.-In the forenoon of the second day the stomach became much affected with nausea and vomiting, everything she swallowed was soon rejected,35.-In five hours had vomited two or three times, in consequence I felt much relieved, though I continued very stupid. The next day a deadly nausea came on me every half hour, and a puking, at first of phlegm, but soon after a copious discharge of bile ensued"; every kind of drink was thrown off my stomach soon after it was taken. At 1 o'clock took a draught of a mixture of a solution of salt of tartar, with lime-juice; this, however, was puked up immediately; it increased the nausea and sickness. I vomited at last a dark-greenish liquid, which deposited in the bottom of the vessel a sediment of the same color,352.—In the course of the second night her stomach became much swelled with flatus,33. -Unpleasant sensation about the region of the stomach (after two hours),

353

Respiratory Organs.-Respiration slow, but not stertorous (after two hours),The breathing 9 respirations per minute (after seven hours),363-Respiration stertorous, irregular, and even sometimes interrupted for a considerable time (after three hours),2-[2360] Breathing was loudly stertorous; respirations only 3 per minute (after two hours); 5 per minute, jerking and stertorous (after three hours),.-Respirations consisted of a series of two or three feeble gasps, with complete intermissions of from one to three minutes (in half an hour),3.- Breathing stertorous,.-Respiration irregular and not full,.-Respirations about 4 a minute, very feeble,.-Respiration slow and difficult (second) morning),2.—Breathing extremely slow and interrupted, stertorous, and gasping,.-Respiration feeble and irregular (after ten hours),6-Ditfi