Generalities.-Three years ago a boy had his feet and legs stung, and every year since then, at about the season of the year he was poisoned, he is taken sick, the same as when first poisoned,*.

Skin.-* The skin of the face, arms, shoulders, and chest was affected with extremely distressing burning heat, with formication, numbness, and violent itching. The lips, nose, and ears, were swollen, and the lids swollen and œdematous, so that they could scarcely be opened. After awhile all the upper parts of the body, as far down as the navel, were frightfully swollen, pale, and oedematous rather than inflamed. A large number of small transparent blisters, filled with serum and looking like sudamina, developed and became confluent; on account of these the skin assumed a peculiar wrinkled appearance. There was no other remarkable disturbance either of circulation or respiration. The patient complained neither of headache nor of sensitiveness of the stomach and abdomen. The look of the patient was monstrous, the lids completely closed, forming transparent, here and there bluish swellings as large as hen's eggs. The upper lip, nose, and both ears were frighfully swollen. On the third day the face became free, but the chest and arm remained affected with an eruption, which itched so violently that the patient scratched off the blisters, which exuded a large amount of serum. The woman, who had had no children for three years and a half, and had nursed none of her children, had at first excessive swelling of the breasts, which discharged at first serum, afterwards perfect milk; a very copious secretion of milk lasted for eight days. The secretion of urine was at first suppressed, and in spite of all diuretics and other remedies, not a single drop was secreted for eight days. During the whole illness there was a constant distressing itching. On the sixth day everything disappeared, with desquamation,'.-*Itching swellings all over the fingers and hands (fourth day); a large number of bumps on fingers and hands, itching at times very severely, much resembling "bold hives "t (fifth day); the "hives" continued until the fourteenth day,'.- Before taking the medicine on the second day, had itching "bold hives" on the left hand, which vanished in a few hours. At 10 P.M., a number of small lumps and red spots on the hands, and fever blisters on the lips, itching a good deal (seventh day). Many "hives" on hands, itching slightly, also a number of red blotches on hands (twentieth day). Many blotches on hands, itching a great deal (twenty-third to twenty-eighth day). A number of blotches still on my hands, but they do not itch (forty-second day),3. Sleep.--[40.] While reading feel drowsy (sixth day),3.

Fever.-On getting into bed felt a heat all over the body, with soreness over the abdomen (fourth day),3.

USTILAGO.

Ustilago maidis, Corda.

Natural order, Fungi.

Common name, Corn smut.

Preparation, Triturations.

Authorities. 1, Dr. Roullin, Memoir to Royal Acad. of Sci., France (Bost. Med. and Surg. Journ., vol. ii, 1830, p. 814), effects when taken into the stomach for a period of time. (2 to 6, W. H. Burt, M.D., Monograph

† A common name for a species of Urticaria, generally Urticaria nodosum. VOL. X.-4

on Ustilago Maidis.) 2, Miss K. O., æet. thirty-two, took 2d dec. trit. three weeks, and then 1st dec. three weeks, in 2-grain doses three times a day, for a uterine tumor of enormous size, which was reduced one-third in size and was greatly relieved of its sensitiveness, greatest effects on skin; 3, W. H. Burt, in perfect health, took 20 grains 2d dec. trit. at 4 P.M. (first day), 20 grains at 12 M. (second and third days); 4, same, took 20 grains 2d dec. at 11 A.M. (first day), 40 grains at 6 A.M., an hour before eating (second day), 40 grains at 7 A.M. (third day), 50 at 7 A.M. (fourth day); 5, same, took 5 grains crude untriturated drug at 7 A.M. (first day), 10 grains (second day), 15 grains at 7 A.M. (third day); 6, same, subsequently feeling very well, but still having complete prostration of the animal system, took 20 grains crude drug at 12 M. (first day), same at 7 A.M. (sixth day), 10 grains in the morning (seventh and eighth days). (7 to 13, T. S. Hoyne, M.D., Trans. Am. Ius. Hom., 1872, p. 493 (six students report that they obtained no symptoms from the drug)). 7, E. H. Pratt, took a powder of 1 grain 2d trit. at 10 P.M.; 8, H. M. B., took same at 12.30 P.M.; 9, Miss M. S. Stearns, took same; 10, S. R. Kridler, took same at 5 P.M.; 11, C. W. Brown, took same at 10 P.M.; 12, R. H. Paine, took same in a spoonful of water at 11 P.M., probably caught cold from exposure on the third day; 13, same, having had no symptoms for a week, took 1 grain 2d trit. at night.

Mind.-Much depressed in spirits this afternoon (third day),.-Have felt irritable and disinclined to talk all day; could not take hold of anything with energy; had nothing particular to complain of (fourth day),. -For three days have felt irritable; almost everything goes wrong (tenth day),12.

Head.-Vertigo. Frequent attacks of vertigo; everything before the eye whirls, sometimes appearing double, and at times myriads of white specks come before the eyes and blot out everything else (second day); occasional attacks of vertigo and internal heat came on for three or four days till the end of twelve days,.-General Head. Dulness of the head (after two days),".-Headache before rising, dull, from dry cold in head; it disappeared after a bath and eating breakfast (third day),".-Dull headache all the morning (third day),'; at 7 A.M. (seventh day),.-Head feels heavy (fourth day),.-In the morning head felt stuffed; felt better after eating breakfast (fourth day),".-[10.] All the morning have had a feeling of fulness of the head, with dull, pressive, frontal headache; dull frontal headache all day, with aching distress in the eyeballs (second day),'.— Head aches most violently at noon; have been very languid to-day, with a bursting frontal headache, 9 P.M. (third day),5.-Slight headache (fourth day),*; (sixth day),.-Forehead. Some headache, mostly frontal, this evening (second day),.-Frontal headache (after half an hour); has continued ever since, with distress in the epigastrium (after four hours); head aches severely, aggravated by walking (after seven hours),'.-Dull frontal headache all the forenoon, with smarting of the eyes (third day),.-Dull frontal headache, in the morning (third day),5; (seventh_day),.-Dull, heavy, frontal headache, while walking in the open air, relieved on staying in the warm room, not from hunger (seventh day),".-Frontal headache, with erections (after three hours and a half),.-Severe neuralgic pains in the forehead, hands, and feet (first day),.-[20.] Sharp pains in the forehead (after one hour),.-External Head. Loss of hair,'.

Eye.-Occasional slight spasms of the eyes, when everything vanishes rom sight and the head seems to whirl (fourth day),'.-Frequent attacks

of twitching of the eyes, and my eyes appeared to look (revolve) in circles and dart from one object to another in quick succession (third day),".— Eyes weak (second day),'.-Aching of the eyes, with profuse secretion of tears (second day),.-Queer feeling in the eyes, smarting or inflamed feeling (after two days),.-Eyes feel hot on closing the lids (fourth day),.Smarting of the eyes, with the dull frontal headache (third day),.-Eyelids agglutinated together, in the morning (seventh day),.-[30.] Eyes weak and water much out of doors (seventh day); eyes water profusely in the open air (ninth day),.-Eyes water much in the open air (sixth day),". -Pain in the right eyeball, with the distress in the stomach (first day),".Aching distress in the eyeballs, with the headache (second day),.-Spots dancing to and fro before the eyes,*.

Nose. A small boil in the right nostril (sixteenth day),".-Thick mucus is discharged from the nose all the forenoon (third day),".-Profuse discharge of thick mucus from the nose, lasting an hour or two (fourth day),".-Thick mucous discharge from the nose, not profuse (fifth day),". -Dryness of the nostrils, with the prickling sensation in the tongue (second day),.-[40.] All the forenoon had dryness of the nostrils, with a dry feeling in the whole skin (third day),3.

Face.-Sudden pallor coming on while sitting and in the evening,10 Face has a dingy-yellow look, more so than natural (fifth day),.

Mouth.-Teeth. Sometimes looseness of teeth,'.-Toothache all day in upper first and second molars; they are decayed and have ached before (sixth day); toothache to-day the same as yesterday (seventh day),.— Tongue. Tongue coated in the morning,".-A prickling sensation in the tongue, and a feeling as if something were under the roots of the tongue pressing it upwards, with dryness of the nostrils (second day),'-Saliva. Profuse secretion of thin bitter saliva (third day); saliva profuse (fourth day),'.-Bitter saliva was secreted in abundance (third day),".-Taste. Slimy taste, with burning distress in the stomach (second day),.-[50.] Slimy coppery taste in the mouth (fifth day); slimy taste in the mouth for a number of days after the proving,.-Slimy coppery taste in the mouth, in the morning (third day); slimy taste (fifth and sixth days); for a week had slimy taste in the mouth, with a relaxed state of the sexual organs (after seven days),.-Coppery taste in the mouth, in the morning (sixth day); slimy coppery taste, in the morning (seventh and eighth days); slimy taste (twelfth day),"..

Throat.-During the night was troubled with mucus in the posterior nares (third day),".-Throat sore and dry towards morning; upper part of throat felt filled up; pharynx and uvula reddened; this passed off in the morning, but the head felt stuffed (third day),".-In a short time felt a sharp lancinating pain in the right tonsil (the fauces were somewhat inflamed when the medicine was taken), (first day); fauces hotter and more sensitive to motion than last night; throat still sore (second day); throat worse, very painful (sharp lancinating pains), (third day); throat still painful (fourth day),.-Left tonsil enlarged and much congested, of a dark-reddish color, right one also quite painful on swallowing, at 2 P.M.; left tonsil much enlarged and painful, at 9 P.M. (seventh day); left tonsil much congested, extending to the ear along the Eustachian tube, which produces constant dull pain in the ear, in the morning (eighth day); tonsils more painful than yesterday (ninth day); left tonsil still congested but not so painful (tenth day); left still congested but not painful (eleventh day),.-Dryness of the fauces with difficulty in swallowing, feeling as if

there were a lump behind the larynx (after half an hour); dryness of the fauces, with a burning distress in the stomach (after one hour); frequent efforts to swallow, with a feeling in the fauces as if something had lodged there (after four hours); irritation of the fauces, with a feeling as if there were a lump in the larynx when swallowing (sixth day); fauces congested and irritated (seventh day),.-Dryness of the fauces, with a burning dryness in the stomach (first day),.-Rough feeling in the fauces (first day),. -[60.] Burning in the oesophagus (soon),".-A burning sensation along the whole length of the oesophagus, especially at the cardiac orifice of the stomach; heartburn, morning, continued all day (second day),.†

Stomach.-Appetite and Thirst. Very hungry (eighth day); craving appetite (ninth day),.-Appetite good; craving for hearty food (fifth day),.-Towards night felt a strong desire for acid food, and ate an apple, which stopped this craving; at the same time had a craving for hearty food, which left on eating the apple (fourth day),".-Poor appetite (fifth day),.-Very thirsty (eighth day); had to get up in the night to drink, was so thirsty (eighth night),-Eructations. Eructations of ingesta strongly acid, with constant distress in the stomach, at 10 A.M.; frequent eructations of sour fluid, at 10.30 A.M. (second day),*.—Eructations of sour fluid from the stomach, with distress in the same region; afterwards eructations of sour food (third day),'.—Stomach. Distress in the stomach (second day),3.—[70] Distress in the epigastrium, with the headache (first day),.-Constant distress in the stomach; frequent pains in the stomach, all the afternoon (fourth day),*.-Constant distress in the stomach all the forenoon, with pain in the right eyeball; have had hard pains in the stomach for the last two hours (after seven hours); severe distress this afternoon, eating supper relieves it (second day),.-Constant burning distress in the stomach, with slimy taste (second day),.-Pain in the cardiac region of a burning character,.-Dull pains in the epigastrium, with constant severe drawing pains in the joints of the fingers (third day),3.-Frequent spells of pain in the stomach and small intestines, with dull distress in the right hypochondrium (sixth day),.-Frequent cutting pains in the stomach, with constant distress in the same region; had the constant severe distress until I ate supper, which relieved it (third day),.-Full_inspiration causes a dull pain in the stomach (second day),.-Burning dryness in the stomach, with dryness of the fauces (first day),".

Abdomen.-Hypochondria. [80.] Drawing pains in the right hypochondrium all day (sixth day),.—A great deal of pain in the right lobe of the liver (seventh day),.-Umbilicus. Have suffered constantly with dull distress in the right hypochondrium and umbilicus (eighth day),.-For the last two hours have had fine, sharp, cutting pains in the umbilical and hypogastric regions, lasting about three minutes at a time, and coming on every ten and fifteen minutes (after four hours); the colicky pains lasted until 8 P.M., when they were relieved by a constipated stool (the first to-day), (after eight hours); since have had constant grumbling pains in the whole of the bowels, with severe pains in the testicles (after ten hours),.—Dull pains in the umbilicus and right liver (seventh day),.-Frequent pains in the umbilicus (eighth day),.-General Abdomen. Pain in the abdomen for two or three days, a very unusual symptom (after two days),9.—

† Kali bich. always gives me the same symptoms, but I had not taken it for two weeks previous.

Occasional pains in the bowels (sixth day),§.—Pain in left inguinal region, while walking,10.

Stool.-Slight diarrhoea, with light-colored stools (second day),'.— [90] Constipated stool, at 8 P.M. (the first to-day), (first day); natural stool, preceded by dull pains in the umbilicus (seventh day); stool at 4 A.M., inclined to be loose, with pain and rumbling in the bowels (ninth day); no stool (tenth day),.-Natural stool (third day); no stool (fourth day); mushy stool before breakfast (fifth day),'.-Natural stool, at 4 A.M. (third day),.-Natural stool (first day); rather soft stool (second day); dry, lumpy stool (third day); black, dry, lumpy stool (fifth day),".-Bowels constipated this morning, a very unusual thing for me (third day); bowels have been constipated all the time (tenth day),2.

Urinary Organs.-Great desire to urinate, the urine being of a lighter color than usual,.-Flow of urine increased (fourth day),'.-Urine very red and scanty, diminished one-half (third day); urine diminished greatly to-day and high-colored (fifth day); urine increased (sixth day); increased and very clear (seventh day),.-Urinated 30 ounces, acid (sixth day); urinated 24 ounces; acids have no effect upon it (seventh day); 23 ounces (eighth day); 26 ounces, high-colored (ninth day); 30 ounces, acid, high-colored (tenth day); 28 ounces, high-colored (eleventh day),".

Sexual Organs.-Male. At 4 o'clock, erections while reading, with frontal headache,.-[100.] Frequent erections during the day and night,.-Relaxed state of the sexual organs, with a slimy taste in the mouth for a week (after seven days); sexual desire was depressed during the whole experiment,.-Scrotum greatly relaxed, with a cold sweat upon it, in the morning (seventh and ninth days); still profound prostration of the sexual system, with the organs greatly relaxed (eleventh day); scrotum still greatly relaxed; sexual desire perfectly prostrated (fifteenth day); this prostration of the sexual system lasted a month after ceasing the proving, With the pains in the bowels, constant severe pains in the testicles, more in the right one (after eight hours); 12 M., constant, severe, dull, aching pains in the testicles, sometimes the pains would be of a sharp neuralgic character; 5 P.M., my right testicle has constantly pained me nearly all day, the pain is of a dull, aching character, at times the distress would be in both testicles; 9 P.M. the dull, aching distress in my testicles has not ceased a moment, this evening (sixth day); 11 A.M., every few minutes have had severe pains in the testicles, lasting about five minutes at a time; the pains produced a faintish feeling; three times had hard paroxysms of pain in the testicles, this evening (seventh day); 5 P.M., have had spells of hard pains in the testicles; 9 P.M., slight pains in the testicles (eighth day),". -Female. *(During these four months it produced a constant aching distress in the womb, referred by the patient to the mouth of the womb),. Respiratory Organs.-Raise a little mucus, of a thick, sticky nature, at nearly every cough (third day),".-Hacking, rough, and painful cough (fourth day),".-10 P.M., have had a cough, with thick mucous expectoration, all day, but am getting better of the cold (fourth day),".— A very little cough and expectoration (fifth day),".

12

Chest.-Feeling of oppression in the chest, along the median line,1o.[110.] In the evening the lungs were sore on coughing (third day),' Heat and pressure in the chest (third day),".-For the last hour have had a constant aching, burning distress under and in the sternum, appears to be in the sternum and also in the stomach, accompanied with fine neuralgic pains in the same region; this is a prominent symptom (third day),.-A