more than twice its natural size, and of a livid, spotted color; respiration quick and laborious; pulse weak, and 115 per minute; surface covered with cold sweat; terrible state of nervous agitation (after four hours),".On the second day the hand and arm was greatly swollen to the shoulder; otherwise the case appeared to be doing well. Thus passed four days, he suffering some cerebral pain and malaise. On the fifth day he spoke of a feeling of soreness in the flesh of the right hip, and on examination a jetblack spot some two inches in diameter was discovered, with elevation or thickening of the skin to the extent of about one line, edges well defined. During the next four days this discoloration extended up to a level with the umbilicus, completely around the body, and down the lower extremities, disappearing at the toes last, when convalescence was established,2.

CROTON TIGLIUM.

Authorities. 64, M. Andral, Gaz. Med. (Bost. Med. and Surg. Journ., vol. vi, 1832, p. 194), effect of application to the skin of from 4 to 20 drops in more than thirty cases; 65, Dr. Maudezin, Gaz. des Hop., 1869, p. 290, a child, æt. six years, took all at once 3 grams of Croton oil in a cup of coffee; 66, G. H. Snead, M.D., Rich. and Louis. Med. Journ., 1872, p. 651, Mrs. S. took two teaspoonfuls of Croton oil mixed with two parts of sweet oil.

The child was taken with the most acute pain in the epigastric region, followed by violent, extremely profuse vomiting for three-quarters of an hour. After this she fell into a profound sleep for a quarter of an hour, when she called for food. She had no more pain in the epigastrium or abdomen, and had only two profuse stools. Afterwards there was a fine vesicular eruption on the lips caused by contact of the oil; in other respects the child seemed well,.-Burning sensation in stomach and bowels ; rapid and drastic purging (soon); pulse 150 and scarcely perceptible; entire surface bathed in cold, clammy sweat; countenance sunken; copious watery choleraic dejections every few minutes (after two hours),.-A few hours after the friction (supposing this to have been employed for some minutes) the patients experienced a smart tingling in the part. In some this sensation was transient; in others prolonged, but never to such an extent as to produce troublesome nervous disturbance; at the same time there appeared a great number of little red points, at the apices of which there were soon perceptible little pustules which, within from thirty to fifty hours, had become fully developed. Many of these became united, and there formed large patches filled with white opaque fluid. The eruption increased for three or four days, after which it remained stationary, and subsequently died away like small-pox. In some cases where the oil was applied to the face the eruption was more copious and intense than elsewhere,&

CUBEBA.

Authority. 9, Thomas S. Page, M.D., Lancet, 1842-43 (1), p. 672, A. T., et. twenty-two years, suffering from gleet, took ounce Cubebs.

Face red and swollen; lips dark purple; mouth containing a viscid frothy saliva; tongue dry, and chapped in the centre; teeth slightly coated with a brown sordes; veins of the forehead and temples turgid; eyes rolled

upward, injected, and their pupils contracted to a point; skin moderately warm and moist, with clammy perspiration; pulse very slow, moderately full, and dispersed by the least pressure; respiration very slow, short, and gasping. By agitating him violently he was aroused for a moment, uttered some incoherent expression, and sank back into comatose sleep,'.

CUNDURANGO.

Authority. 3, H. E. Dikeman, M.D., New Eng. Med. Gaz., vol. x, 1875, p. 486, proving with the officinal tincture; took 3 drops diluted in ounce water three times, and 4 drops twice (first day); 5 drops twice and 4 drops twice (third day); 4 drops at 6 A.M., 5 at 9 A.M., and grain Sulph. morphia at 4 P.M. (fourth day); 5 drops Cundurango three times (fifth day); 10 drops (sixth day).

Mind.-Confusion of mind (fifth day),.

Head.-Dizziness (fifth day),.-Headache, frontal (first day),.-Dull headache in frontal region (third day),.

Eye.-Pain in the ball of the left eye (third day),.-[80.] Sight much dimmed (seventh day),3.

Mouth.-Tongue coated brown (seventh day),.-Tongue feels as if burned (first day),.—Acrid, burned feel of the tongue (fifth day),.

Stomach.-Feeling of fulness of the stomach (first day),.-Cardialgia (third and fourth days),.-The pain in the stomach is intolerable (fourth day),.-Severe gastric pains, mostly at the cul de sac of the stomach (seventh day),.-Have a contiuuous pain in the stomach, like gastritis in character, though not affected by food or drink, heat or cold (seventeenth day),.

Abdomen.-Flatulence (third day),.-[90.] At 8 A.M. there is an uneasy feeling, not quite a pain, in, I should judge, the iliac region (third day),-Uneasiness of the bowels (fifth day),.

Stool.-At 8 A.M. a stool, small, papescent, without any sense of aid from the sphincter muscles, some mucus mingled (third day),.-Constipation (fifth day),".-On the whole the bowels have been costive. When I had a stool the excrement was small in quantity, and dry in quality,3.

Urinary Organs.-Weary ache in left kidney (third day),.-Occasional darts of pain through the kidneys (fifth day),.-Strangury, imputed to the Morphine (fifth day),".-Urinated several times during the night, with urging of the renal ducts (first night); urinate frequently (third and fifth days); still urinate frequently, at times an unusual quantity (seventh day),3.-The urine is almost colorless, emitted without effort, and there is urging in the renal ducts after the bladder is emptied (seventeenth day),".

Pulse. [100.] Pulse slightly accelerated (after three hours); slower than natural, at 8 P.M. aud in the night (first day); small and slow (seventh day),3.

Back.-Pain in right scapular region, as if in the bone (first day),'.Pain about fourth dorsal vertebra (first day),".-Pain under apex of left scapula (third day),.

Extremities. Slight creeping pain along the periosteum of right humerus (first day),3.—Apparent increase of strength of legs when walking (fourth day),.

Generalities. - Have increased in weight since commencing this

proving (seventeenth day),.-Great stiffness of muscular system (fifth day),.-Languid when awake in the night (first night),3.

Skin.-Skin tinted brown (seventh day); still brown (seventeenth day),.-[110.] (Several chronic blotches on my skin are no longer visible; also a puffiness of hands and feet, that I attribute to various causes, without knowing the real one, has subsided), (third day),.—Itching of legs along anterior and outer tibial region of both legs (third day),3.-Great itching in scapular region and on legs (fourth day); much itching of skin on shoulders, over sternum, and on anterior surface of tibia (fifth day),. Sleep. Slept last night as if narcotized (third night); had a narcotized sleep last night from the alkaloid (fourth night),”.—Had a night of intermittent sleep (first night),3.

Fever.-Rigors (first and third days),”.

CUPRESSUS AUSTRALIS.

Natural order, Coniferæ.

Proving by A. B. Jenner, Esq., and two others, with the tincture; Month. Hom. Rev., 9, p. 544.

Mind. He is in much better spirits.

Head.-Pain in frontal region, rather dull than acute.-Sharp piercing pain from left occiput to left temple.

Stomach.-Increase of appetite, followed by loathing of food.-Voracious appetite.-Feeling of warmth in stomach.

Urinary Organs.-Pricking pains from kidneys to bladder, with increased desire to urinate, which comes away in a smaller stream than usual.-Feeling of constriction along the course of the urethra, particularly towards neck of bladder.

Sexual Organs.—Itching of glans penis, and orifice of urethra.— Aching pain in perinæum and in spermatic vessels, with feeling of weight

in testes.

Back.-Dull aching pain in lumbar region.

Superior Extremities.-Pain in shoulders, especially on joint of right shoulder, extending down to elbow.

Inferior Extremities. Pinching-drawing pain in knees, and along lymphatics of legs.-Sharp, shooting pain in patellæ, and in bend of knees.-Feeling of tension in calves of legs, with occasional spasmodic twitchings, and a feeling of general malaise, all over body. Fever.-Increased heat of body, without thirst.

CUPRUM.

Authorities. 56, R. A. Stafford, Lond. Med. Gaz., 1844-5 (Amer. Hom. Obs., 1876, p. 77, E. W. Berridge's Collection), Margaret P., æt. sixtyeight years, pricked her right thumb with a pin, which ran into the flesh about one-eighth inch; she often scoured out a dirty copper; 57, same, poisoning of Hester J., æt. sixty-five years; 58, E. W. Berridge, U. S. Med. Invest., vol. iii, 1876, p. 282, took ten doses of 3 glob. each of 100,000th (Fincke), at intervals of one to one and a half hours.

Head.-Afternoon, giddy when standing indoors (ninth day),5.

Throat.-In morning mucus in throat, not to be detached by hawk

ing, causing hoarseness of voice (second and third days); at times hoarse voice when reading aloud, caused by mucas in the throat, relieved by hawking; in the evening after sunset, when reading aloud, much saliva in mouth (sixth day); in evening after sunset, when reading aloud, hoarseness and much saliva in mouth (ninth day); hoarse voice in the morning (fifteenth day),58.

Generalities.-The thumb immediately swelled to double its natural size. Next day the whole hand and arm became immensely swollen and inflamed. She had great pains; fever came on, with quick pulse, thirst and furred tongue; the inflammation rapidly spread in the cellular integument of the forearm, or on the humeral part; leeches, fomentations, poultices, etc., were applied, but extensive abscesses formed, both in the hand and arm; these were opened, but others appeared in different parts of the cellular integument, and under the fascia; large incisions were made in them, and a profuse discharge of pus followed. This state of things remained for at least two months, when the inflammation of the arm gradually abated, and the wound healed; but the hand, and more particularly the fingers, remained humid, and more resembled the foot of an elephant (or the disease called elephantiasis) than the natural limb. The fingers and back of the hand were oedematous, and it was necessary to make frequent punctures in them to let out the fluid, which was transparent; abscesses still formed in the palm and wrist, which were opened when necessary; at length it became necessary to make an extensive incision from the middle of the forearm along the wrist, over the tendons, into the palm. From this time the swelling went down, and the wound discharged freely; after four months' treatment she got well, and ultimately will have a tolerably free use of the hand,56.-She was admitted January 21st, with abscesses in right hand, a diffuse cellular inflammation, extending a considerable way up forearm; both hand and arm were immensely swollen, and painful; she says the copper wires of the brush she was using, which were "cankered," ran into her palm; on the same evening her hand was extremely painful, and she could not use it; it began to swell to nearly double its natural size; an abscess formed in the palm, which was opened and poultices applied; other swellings formed, both on the back and palm of hand, containing pus; these, as fast as they occurred, were opened, but sloughing took place over the tendons of the wrist, which were exposed. This state lasted two months; at length the wounds healed, and in March she was discharged cured,57.

CUPRUM ARSENICOSUM.

Authorities. 20 (Berridge), Echo du Monde Savant (Med. Times, 1840, vol. ii, 141), five persons drank water impregnated with Cup. ars.; 21 (Berridge), Dr. Mitchell, Dublin Med. Press, 1843, vol. ix, p. 52, fifteen children ate sweetmeats colored with Ars. and Cu.; 22, omitted; 23 (Berridge), Scheele's green, from Encyclop. des Sci. Med. (Am. J. of M. S., 1846, vol. xi, p. 252); 24 (Berridge), Dr. Prosper de Pietra Santa, L'Union Med., Sept, 1858 (Edinb. Med. Journ., 1860, vol. v, p. 961), diseases of workers in Schweinfurt's green; 25 (Berridge), Dr. S. Griswold, N. Y. Journ. of Med., 1858, vol. v, p. 64, J. F., æt. thirteen years, was engaged in making paper in which Scheele's green was used; 26 (Berridge), Dr. H. Cooper Rose, Lancet, 1859 (1), p. 237, poisoning of a child, æt. nine

months; 27, omitted; 28 (Berridge), Dr. W. G. Blogg, Lancet, 1860 (2), p. 596, effects on workmen in Scheele's green; 29 (Berridge), Dr. Hassal, Lancet, 1860 (2), p. 535, effect on manufacturers of Scheele's green; 30, ibid., effect on a man, æt. forty-five years; 31, ibid., effect on a man, æt. twenty-seven years; 32 (Berridge), Dr. J. B. Metcalfe, Lancet, 1860 (2), p. 535, case of poisoning; 33 (Berridge), Dr. Wintrebert, Bull. Med. du Nord. (Lancet, 1873 (2), p. 49), effect of local use of green paper; 34 (Berridge), Kittel, Allg. Wiener Zeit. (Lancet, 1873 (1), p. 174), conjunctivitis due to Schweinfurt's green; 35, Joseph Farrar, Brit. Med. Journ., Jan. 6th, 1877, a man, æt. twenty-two years, was in the habit of holding his paint brushes between his teeth, and neglected to wash his hands before eating.

Mind.-Nervousness,".-Extreme depression of spirits,".-Constant feeble moaning,25.-Semicomatose state,.-Lying on back in bed, partially comatose, writhing and twisting himself from side to side, but so prostrated in strength as to be unable to rise or sit up,25.

Head.-[230.] Headache,"

Eye.-Eyes sunken,".-Eyes dim and glassy,.-Edema about eyes,2. -Eyes swollen, in morning,".-Several girls who worked with it were affected. It generally began with an intense pain in the eyes and photophobia. Acute catarrh then followed, accompanied by redness and desquamation of internal surface of eyelids. In some cases there was to be seen on the papillary body of the lower lid a small round grayish patch, which stuck to the surface, and on being removed caused slight hæmorrhage. The conjunctiva of the upper eyelid never presented this appearThe inflammatory process caused some thickening of the conjunetiva, and consequently some swelling of the lid. There generally existed at the same time various inflammatory lesions round ala nasi,".-Eyelids somewhat red and puffy,.

ance.

Nose.-Soreness of and running from nose,".-Nose sore inside, and discharging freely,31.

Face.-Paleness of the face,.-[240.] Countenance had a peculiarly pale grayish appearance,.-Pinched features,.-Convulsive twitchings of facial muscles,-Lips and nose swollen to double their natural size,.

Mouth.-Gums tender,".-Tongue white,.-Tongue raw-looking, with portions of its upper surface denuded of epithelium, sore to the touch, and somewhat enlarged in size,35.

Throat.-Soreness of throat and gums,29.

Stomach. Loss of appetite,.-Violent vomiting and purging during the previous half hour. He was now cold and clammy to touch, the pulse not perceptible at the wrist, and with all the symptoms of collapse,"-[250] Vomited severely a green slimy substance mixed with solid material for upwards of an hour,".-Vomiting and purging, accompanied by pain in the abdomen of a colicky character, and so severe as to be best expressed by the word excruciating..-Painful digestion,".

Abdomen.-Abdomen distended and tympanitic,.-Almost contin

ual colic,20.

Anus.-Ulcerations of anus,33.

Stool.-Severe dysentery,"2.-Stools passed involuntarily, watery, bilious, and very offensive,".-Purgings, passed about two quarts of thin, yellow faces, 25.

Respiratory Organs.—Breathing imperfect and irregular, being short and quick, and more slow and gasping, by turns,25.