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average amount of uric acid excreted for each period of twenty-four hours was 0.77 grams. Quantity of urine excreted 1685 cubic cent., sp. gr. 1021.5; total amount of solids 70.15 grams, of which 30.90 were inorganic, and 39.25 organic matter; quantity of uric acid 0.81 gram (first day). Quantity of urine 1720 cc., sp. gr. 1020.87 ; total solids 75.29 grams; inorganic solids 32.44 grams; organic solids 42.85 grams; uric acid 0.69 grams (second day). Quantity of urine 1784 cc. ; sp. gr. 1022.57; total solids 80.13 grams; inorganic salts 35.11 grams; organic solids 45.03 grams; uric acid 0.82 gram (third day). Quantity of urine 1540 cc.; sp. gr. 1023.17; total solids 69.23 grams; inorganic solids 31.09; organic solids 38.14; uric acid 0.78 gram (fourth day). Quantity of urine 1698 cc.; sp. gr. 1023.68; total solids 76.14 grams; inorganic solids 32.36 grams; organic solids 42.88 grams; uric acid 0.76 gram (fifth day),'': -Average daily quantity of urine 989 cc.; sp. gr. 1020.14; total solids 51.20 grams: inorganic solids 22.45 grams; organic solids 28.75 grams; uric acid 0.47 gram (before experiment); quantity of urine 1021 cc.; sp. gr. 1024.18; total solids 63.25 grams; inorganic solids 23.57 grams ; organic solids 40.68 granis; uric acid 0.59 gram (first day); quantity of urine 875 cc. ; sp. gr. 1026.11 ; total solids 60.25 grams; inorganic solids 20.38 grams; organic solids 39.87 grams; uric acid 0.51 gram (second day),".
Respiratory Organs.—[1210.) Coughed severely at regular intervals,? - Blood in sputa," - Breathing rapid ; heavy, almost stertorous (after a few hours),"?.
Chest.-Great fulness of the chest,"? Pulse.-Pulse 80 (before experiment); 78 (in five and ten minutes) ; 76 (in fifteen and twenty minutes); 78 (in twenty-five and thirty minutes); 80 (in thirty-five, forty, and forty-five minutes); 78 (in fifty minutes); 76 (in fifty-five minutes) ; 72 (in sixty minutes); 70 (in sixty-five minutes); 68 (in seventy and seventy-five minutes ); 72 (in eighty and ninetyfive ininutes); 70 (in one hundred minutes); 72 (in one hundred and five, one hundred and ten, and one hundred and fifteen minutes); 76 (in one hundred and twenty minutes); 80 (in one hundred and eighty and two hundred and forty minutes),S6 - In five minutes after taking the medicine, his pulse became considerably reduced, both in force and frequency ; in thirty-five minutes be had a copious discharge of pale-colored urine, his pulse much increased ; in fifty ninutes, very sleepy, pulse again reduced ; in seventy minutes, his mental faculties became much exhilarated, pulse very slow and soft ; in ninety minutes, perfectly free from any peculiar feelings, pulse somewhat increased ; in one hundred and eighty minutes, pulse very natural,66 — Pulse 70 (before experiment); 52 (in five minutes); 48 (in ten minutes); 46 (in fifteen minutes); 42 (in twenty and twentyfive minutes); 48 (in thirty minutes); 43 (in thirty-five minutes); 45 (in forty and forty-five minutes); 39 (in fifty minutes); 43 (in fifty-five minutes); 46 (in sixty minutes) ; 50 (in sixty-five, seventy, and seventy-five minutes) ; 45 (in eighty, eighty-five, and vinety minutes); 47 (in ninetyfive minutes); 50 (in one hundred, one hundred and five, one hundred and ten, one hundred and fifteen, one hundred and twenty, and one hundred and twenty-five minutes); 53 (in one hundred and thirty minutes); 55 (in one hundred and thirty-five minutes) ; 57 (in one hundred and forty minutes); 60 (in one hundred and forty-five, one hundred and fifty, one hundred and fifty-five, one hundred and sixty, and one hundred and sixty-five minutes); 65 (in two hundred minutes); 70 (in two hundred and seventyfive and three hundred minutes),87.-In five minutes after taking the med
icine my pulse became diminished, both in force and frequency; in fifteen minutes I felt considerable flushes of heat passing over my face, and followed by a considerable degree of vertigo ; in fifty minutes, my pulse became still more diminished; in sixty-five minutes, I was somewhat sleepy; and in seventy-five minutes, I was very sleepy, attended with a slight diaphoresis ; in one hundred and thirty minutes, my pulse began to increase in frequency, but continued diminished in force; and in two hundred and thirty-five minutes, was natural, both as to force and frequency,57.-Pulse 160 ; grew feeble (after a few hours),9%.
Superior Extremities.-Numbness in the arms,".-[1220.] In a few seconds his fingers changed color, and took the livid greenish tint characteristic of a corpse in a state of incipient decomposition. After about ten seconds the skin regained its color,91.-Cramps of the fingers,
Generalities.—Convulsions," --Extreme prostration, suffering from excessive nausea and vomiting, with slight purging, heat and burning in the fauces, inordinate thirst, cold, clammy skin, feeble pulse, violent supraorbital pain, and distressing gastralgia, with very anxious countenance, -Pale, cold, vomiting constantly, purging, and complaining of great thirst and pain at the epigastrium,99:- The symptoms were mainly those of violent cholera morbus,9 — Debility," — Very much exhausted,"? - Similar symptoms, but milder, except the headache, which he described as most intense,93
Fever.—[1230.] Shivering, 95. —Coldness, 95. — Whole body clammy and cold,"2 — Feet and hands cold,".-Cold sweat on forehead,"
Authority. 2, M. M. Dowle, M.D., U. S. Med. Invest., N. S., 3, 1876, p. 386, took a teaspoonful and half of the powder.
After about half an hour, while partaking of warm mashed potatoes and hot sweetened milk, at supper, I first experienced a warmth in my lips, and simultaneously a tensive, pressive headache at the point of emergence of the supraorbital nerve of the left side. Pressed with thumb over the spot to relieve the aching Presently, say perhaps ten minutes later, headache was no longer noticed, only an increasing warmth spreading along the internal mucous surfaces of the upper and lower lips; the sense of warmth was deepening rapidly into a feeling of largeness of the parts, attended with a sensation as if the parts were occupied with innumerable needles, which were darting back and forth.
The face, as the cheeks, the forehead, and also all the hairy parts of the under chin, from ear to ear, and thence reflected down almost to breastbone, seemed to feel the same numbness or needlelike darting to-and-fro sensation. Strangely enough, the tongue did not share the same sensations. (There was a caustic sensation in the fauces, which induced some coughing and spitting when the powder was first swallowed, but there was no universal burning in the throat-pit or gullet at any time afterwards.) While the inner surface of the lips, as well as the whole buccal mucous cavity were experiencing an intensity of excitement, the face seemed to grow broader and broader, making the prover feel, in humorous phrase, as if he had a touch of the “ big-head." The mind partook of the sense of pleasurable exhilaration.
Next, the entire right forearm, from the elbow to the tips of all the fingers, felt the sepse of numbness, a weary heaviness; then the left arm and its fingers. The balls of the two thumbs were very numb; they were worse than the fingers. Rested my head at supper-table on my left hand. Felt a sense of nausea, and thought I must vomit. No better in the open air. Lips seemed growing larger all the while, and mouth seemed to stand open like a huge catfish's; lips dry; no flow of saliva at any time during the proving
Lay down on bed with coat and boots off, with a blanket as covering ; lay there from five to ten minutes ; mouth tingling and burning; lips “enlarging;" face flushing and pricking, and whole head seeming to take on "growing” dimensions; both arms, from elbows to finger-tips, “fast asleep,” and hands feeling as broad and heavy again as they naturally were. Wanted to lie with head high, to get more air; suddenly, low down in left lung, felt a gurgling, followed by an immediate desire to cough, which I restrained, because just three weeks from this date the prover had a slight attack of hæmoptysis coming from that side, which was checked with Trillin. Uneasy; got up in stocking-feet and shirt-sleeves, and sat near stove. Was, if possible, growing worse. Head seemed to grow bigger while straiving to get boots on; went to front door, and staggered against the large elm tree near the step. While closing shutters felt sick and faint, and re-entered house. At no time did there seem to be any striking departure from a natural breathing; the breathing and pulse did vary, however, while lying down; the pulse under the finger would withdraw like a thread, and then return with more volume. This condition of my pulse was noticed while lying on my left side, recently affected as stated, and I got up to avoid, if possible, a return of that trouble. Hot things taken into the mouth and swallowed, seemed at all times to intensify the effects of the medicine. Had I taken the medicine by mistake in the dark, I would have compared the sensations experienced to those of Aconite; it seems the analogue of Arum triphyllum also. To antidote the Collinsonia action I employed Chloride of sodium; the spirits of Camphor containing Laudanum was used by olfaction, but the mucous membrane of the nostrils, as far within as this volatile stimulant penetrated, seemed only to resent its presence by inducing an unwelcome aggravation of the existing local troubles. Nux vom. was the antidote. The face returned to a feeling of. naturalness with each dose; the Collinsonia effects seemed to pass away like a vapor or aura from above downwards; it was felt to move; the sensations of relief being first felt in the forehead; then the cheeks lost their grotesque unbecomingness, or largeness ; next the lips parted with their pungent glow, while the two arms, down to their finger-tips, were next severally alike bettered. However, the balls of the thumbs persisted in their numbness, the right feeling somewhat unnatural even the next day. To restore the thumbs and fingers to their right feeling, I slapped my outspread hands at the time across and around my sides, as the wood-chopper does when his hands are pumb with cold.
These toxic sensations lasted fully three hours, say from 6 to 9 P.M. Feeling “well ” at this latter hour, I visited a lady patient, a block from my dwelling. In the cool, open air, walking, my feet and limbs felt strangely light, like a deer's, and as though I could run very fast if chased. I seemed to lose the sense of physical or personal identity, as far as the lower extremities were concerned. Returning home, after an absence of perhaps ten minutes, I now felt for the first time a strong glow in the
bowels, from the umbilicus clear down to the toes. A sense of increasing largeness and numbness was felt from hip to hip; while the right thigh was thus affected, the left was skipped ; the calves of both legs seemed elephantine, and "fast asleep." I sat still and sipped Nux vom. The dynamic antidotal effect which this agent has over the Collinsonia poison in the system was decided, and it was felt to be like removing a swaddling-cloth that embarrassed nervous action by its tightness and weight. I took a teaspoonful of a solution of twenty drops of the 1st attenuation of Nux vom. in twenty teaspoonfuls of water, every few minutes. Urinated several times, and had a stool during proving, the latter being in the form of balls, or lumpy agglomeration,
Authority. 56, Henry Usher. The Organon, vol. i, Jan. 1878, p. 104, effects of 6th dec. in three doses.
Dark redness and painfulness of the frænum penis; it ceased after a while,
Revision of authorities, by Dr. J. Hyde, Am. Observer, xiii, p. 629.
No. 1, Dr. J. Hyde, proving, 1854, with a drop of the footh dil. ; 2, Miss J., 4, afterwards 3 drops ; 3, Mr. G. took pellets saturated with the Goth ; 4, same; .... 8, provings by Dr. J. Hyde, Am. Obs., xiii, 593, 10 drops in water at 10.30 A.M. and 12.30 P.M., 20 drops at 4.30 P.M. ; 8a, same, 10 drops at 6.30 A.M. (first day), same at 6.10 A.M. (second day), 25 drops at 6.30 A.M. (third day), 40 drops at 4.10 P.M. (seventh day); 86,3 drops at 5.30 P.M. and 11 P.M. (first day), 3 drops at 7.30 A.M. and 1 P.M., 4 drops at 4.15 P.M. and 9.50 P.M. (second day), 8 drops at 12 m. and 2.20 P.M. (third day); 8 c, same, 10 drops at 3 and 10.55 P.M. (first day), same at 7.4 A.M. and 3.30 P.M. (second day), put 2 ounces of cold water and 10 drops of 1st dec. into Fullgraff's inhaler, and inhaled for twenty minutes, at 11.45 A.M. and 3.30 and 10.30 P.M. (tenth day); inhaled twenty minutes at 2.30, 5, and 10.25 P.M. (fourteenth day); inhaled twenty minutes at 2.30 P.M.; took 8 drops at 10.55 P.m. (fifteenth day), 12 drops at 4.35 P.M. (sixteenth day).
Mind.-A cheerful condition of mind during the forenoon (first day),
Head.—[190.] While inhaling at 10.25 P.M., aching in the os frontis and orbital bones (fourteenth day),*.-Dull aching in the forehead, and on moving the head a sense of fulness, rigidity, and lameness of the muscles of the neck, in the afternoon (sixteenth day), e-Pain above the left eyebrow, at 4.12 P.M. (second day), -11.30 P.M., while lying on the right side, an aching in the right temple, followed by an aching and sense of fulness in the right side of the face (second day), . --Aching in the right temple and right orbital bones, at 6 P.m. (second day),sc -2.35 P.m., a sharp pain passing down the right temporal ridge and external angular process. "Immediately after a sharp pain at the right supraorbital ridge, close to the supraorbital notch (fourth day),*--4 P.M., aching in the right temporal bone, commencing in the temporal ridge and extending to the occiput; the
whole base of the head is very painful on moving the head, also the stervomastoideus and trapezius muscles (twelfth day),.
Eye.-The Meibomian glands of the upper lid of the right eye are inflamed (fourteenth and fifteenth days); inflammation subsided (eighteenth day)..
Ear.-Heat and fulness in the interior of the right ear, at 1 P.M. (third day),
Face.-5.10 P.M., after slight exercise in the open air, and while in my room, an aching in the left maxillary articulation, leaving a sense of fulness; immediately after an aching in right maxillary articulation, terminating in a sharp pain ( nineteenth day),60 - [200.] 5.22 P.m., after a short walk in the open air, and having entered a warm room, an aching in the right maxillary articulation, involving the wbole of the right side of head (nineteenth day),:-9 A.M., an aching in the ramus of the right maxilla (seventeenth day),.-10.30 P.M., aching at the base of the right antruin of Highmore, then at the base of the left antrum (tenth day), c.-10 A.M., while at rest in my office, heat and sense of fulness in the face, over the superior maxillary bone (first day),4-10 A.M., while at rest in my office, a sensation as of a pimple over the right antrum (first day),**:—9.15 A.M., sensation as of a scabby eruption on the median line of the lower lip, close to the vermilion border (third day),84:—10 A.M., while at rest in my office, a corrosive burning on the left side of the lower lip (second day),da
Mouth.-5.30 P.M., aching in the upper molar teeth and gum of the right side, aggravated by cold air (second day),s".—1 P.M., immediately after dinner, an aching in the body of the last molar tooth of the right side of the lower jaw (third day), - At 3 P.M., while sitting in my office reading, an aching in the lower incisors, passing to the riglit cuspid and bicuspid teeth, continuing five minutes (first day),.—[210.) 4.30 P.M., aching in the lower incisors, which leaves them very sensitive to pressure from the upper teeth (third day),*4.-5.30 P.M., while at rest in a warm room, a sore aching of the gum of the right upper molar teeth (nineteenth day), -A short, cutting pain in the gum of the first lower molar tooth of the left side, at 1 P.M. (third day),s".
Throat.-3.30 P.M., while at rest, a sense of expansion in the cesophagus, as of air ascending slowly from the stomach (third day),**.
Stomach.-Appetite for dinner less than usual (first day),.—No appetite for dinner (first day), ** -An acrid, rancid sensation while walking in the open air, at 3.30 P.M.,6-11 A.M., an eructation of tasteless air (first day),ta. – 10.15 A.M., while at rest, an eructation of air tasting of the drug (first day), . --4.30 P.M., eructation of tasteless air (third day),64 —[220.] An eructation of sour, acrid water, at 2.5 P.M. (tenth day), -10.10 A.M., after a walk in the open air and soon after entering my office, an intense acrid eructation, producing momentary strangulation (twelfth day),* -Hiccoughed several times, at 3 P.M. ; immediately after gaped several times (tenth day), - About 11 P.M., while lying on the left side, an expansive, intense distress in the epigastric region, like unto heartburn, extending through the posterior border of the left scapula, continuing half an hour. Amelioration by lying ou the right side (tenth day),-10 P.M., pain in the epigastrium, as of Aatus (sixteenth day),
Abdomen.-Soon a tense feeling in the abdomen, as if the bowels were full of flatus (second day),84.–Soon after breakfast, and while walking in the open air, expulsion of odorless flatus per anum (second day), a. -3.40 P.m., pain in the right side of the abdominen, running downwards,