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Sleep.-Slept remarkably well last night; dreaming that something was adhering to fauces at posterior entrance to nares which he was trying to detach; woke about 8 A.M., actually in the effort, and there really was mucus there to detach; still has the smarting soreness (second day),**.

Ferer.-Increase of subjective warmth,'*. —Coldness of the extremities,".-General perspiration," :-[560.] Cutaneous secretion rather diminished,


CODEINUM. Authority. 11, C. Ambrosoli (Gaz. Lombardo, 1875), Brit. and For. Med. Chir. Rev., 1876, p. 235, poisoning of a child, aged two years.

Face pale, extremities cold, pulse small, abdomen distended with flatus, eyes glassy and immovable,".

COFFEA TOSTA. Authority. 9, Dr. Curschmann (Deutsche Klinik, No. 41), Med. Times and Gaz., 1873 (2), p. 581, additional symptoms; 17, Dr. Eust radiadis, Etude Exper. sur les Prop. Phys. de la Cafeine et du Cafe, Paris, 1870.

Mind.She recognized those about her, and was aware of the cause of her sufferings, but still her sensorium was evidently not quite clear; and next day she retained only a very obscure recollection of what had occurred. Plain or connected answers were not obtainable from her, and only after much effort and persuasion would her attention be engaged at all, she continuing to incessantly repeat the same phrases in the most dolorous tone,

Eye.-The pupils somewhat enlarged, acted normally,'.

Stool.-In one hour severe diarrhea, which continued to recur about every half hour for long afterwards,".

Urinary Orgams.-Frequent desire to pass urine, which came on every quarter of an hour. The urine having a specific gravity of 1014, was considerably increased in quantity,'.--The general conclusions were that there was great diminution of urea, over 15 per cent. Coffea did not prove a diuretic, though there was increased frequency of micturition,".

Respiratory Orgmis. -- Respiration painful, short, and rapid, counting from 24 to 30,".—Complained of want of air, and a sensation as if her chest were compressed, and clung convulsively to articles of furniture or the persons near her, but sinking down again quite powerless,'.

Heart ind Pulse.--[160.) Distressing palpitation, and the impulse seemed almost to raise the chest,". - Pulse 112,'.

Extremities.- The limbs, and especially the hands were affected by chorealike movements, so that the patient was unable to hold either a glass or spoon,


Ferer.- The forehead was cold, and the temperature of the other parts of the body did not seemed raised,'.


Authority. 5, Dr. Kelp, Memorab., 22, 1877 (S. J., 176, 220), a woman took two powders of the citrate, each containing 0.24 gram.

She was seized with remarkable restlessness and dizziness, and could not keep erect. Violent præcordial anxiety, palpitation. Abdominal pulsation. Violent trembling of all the extremities. Grating of the teeth.

. Features expressive of the greatest anxiety. Feeling of constriction of the neck and throat, recurring periodically every fifteen minutes. Pulse very rapid. This condition lasted three hours, and gradually disappeared,".

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COLCHICUM. Authorities. 86, J. Y. Clark, M.D., Am. Med. Rec., vol. I, 1818, p. 369, John R. Peckworth took 100 drops of tincture; 87, ibid., the author took 100 drops ; 88, Thos. Kennard, M.D., Am. J. of M. S., 1857 (1), p. 69, a woman, æt. fifty-six years, took one ounce of Colch. wine in twelve hours ; 89, Dr. Fifield, Bost. Med. and Surg. Journ., vol. Ivi, 1857, p. 78, a man, æt. twenty eight years, suffering from rheumatism, took half an ounce of Colch. wine ; 90, W. A. Hammond, M.D., Am. Med. Monthly, Feb., 1861, p. 83, took 1 fluid drachm at 8 A.M., 2 and 10 P.M. (first day); 1} fluid drachms three times (second and third days); } drachm (fourth day); 1} drachms (fifth day); 91, ibid., a man, æt. twenty-three years, took 1 drachm tincture three times (first day); 1} drachms three times (second day); 92, John H. Garner, M.D., Canada Lancet, vol. iii, 1871, p. 307, R. H. drank about a pint of tincture ; 93, ibid., J. M. J. took same quantity ; 94, ibid., T. H. took a small quantity; 95, W. E. Porter, Med. Times and Gaz., 1874 (2), 723, poisoning of two children, æt. four and two years ; 96, Canada Pharm. Journ. (Pacif. M. and S. Journ., April, 1874, p. 572), a party of seventeen persons drank from one or two ounces to a pint each, of the wine, seven died; 97, J. Pierre, Comptes Rendus, vol. Ixxix, p. 633 (Pharm. Journ. and Trans., Oct., 1864, p. 325), the author plucked some fully expanded flowers, afterwards extended his hand over a large clump of Howers, carefully avoiding all contact, with the same result.

Minil.-Muttered and raved wildly at times, but it only lasted a few minutes, 9. —Comatose, 92.

Herid.-[1190.) Intense headache,
Eye.-Eyes red and watery, and the pupils dilated,92.
Ear.-Much tinnitus aurium,”.

Face.-Expression of countenance anxious and haggard,9%— Hectic
flush occasionally on cheek-bones,"?
Mouth.-Tongue dry and brown in the centre, and red along the edges, 92.
Stomach.-Great thirst," 95. - Nausea,".-Sickness, *. - Vomiting in

– from three-fourths of an hour to an hour and a half,96.—[1200.] The ejecta were bilious, and then of the rice-water character, 96.

Abilomen.- Extreme tenderness over abdomen, and the intermittent severe pains precisely similar to peritonitis," -Tormina,»5.

Rectum and Anus.– Tenesmus,95.

Stool.-Purging,%-Severe diarrhea (second day),"! - Purged and vomited violently," --Purging in from three-fourths of an hour to an hour and a half, when a large quantity was taken; later when the quantity was small,96

Urinary Organs.- In three days immediately preceding commencement of experiment, the average quantity of urive for each day was 1425 cubic cent.of 1021.73. The average amount of solid matter was 64.28 grams; of which 30.18 were inorganic, and 34.10 organic substance. The




92 93








average amount of uric acid excreted for each period of twenty-four hours was 0.77 grams. Quantity of urine excreted 1685 cubic cent., sp. gr. 1021.5; total amount of solids 70.15 grams, of which 30.90 were inorganic, and 39.25 organic matter; quantity of uric acid 0.81 gram (first day). Quantity of urine 1720 cc., sp. gr. 1020.87 ; total solids 75.29 grams; inorganic solids 32.44 grams; organic solids 42.85 grams; uric acid 0.69 grans (second day). Quantity of urine 1784 cc.; sp. gr. 1022.57 ; total solids 80.13 grams; inorganic salts 35.11 grams; organic solids 45.03 grams; uric acid 0.82 gram (third day). Quantity of urine 1540 cc.; sp. gr. 1023.17; total solids 69.23 grams; inorganic solids 31.09; organic solids 38.14; uric acid 0.78 gram (fourth day). Quantity of urine 1698 cc.; sp. gr. 1023.68 ; total solids 76.14 grams; inorganic solids 32.36 grams; organic solids 42.88 grams; uric acid 0.76 gram (fifth day),. — Average daily quantity of urine 989 cc.; sp. gr. 1020.14; total solids 51.20 grams; inorganic solids 22.45 grams; organic solids 28.75 grams; uric acid 0.47 gram (before experiment); quantity of urine 1021 cc.; sp. gr. 1024.18 ; total solids 63.25 grams; inorganic solids 23.57 grams; organic solids 40.68 granis; uric acid 0.59 gram (first day); quantity of urine 875 cc.; sp. gr. 1026.11 ; total solids 60.25 grams; inorganic solids 20.38 grams ; organic solids 39.87 grams; uric acid 0.51 gram (second day),".

Respiratory Organs.-[1210.] Coughed severely at regular intervals,9?- Blood in sputa,92 — Breathing rapid ; heavy, almost stertorous (after a few hours),"?.

Chest.-Great fulness of the chest,92.

Pulse.--Pulse 80 (before experiment); 78 (in five and ten minutes); 76 (in fifteen and twenty minutes); 78 (in twenty-five and thirty minutes); 80 (in thirty-five, forty, and forty-five ininutes) ; 78 (in fifty minutes); 76 (in fifty-five minutes); 72 (in sixty minutes); 70 (in sixty-five minutes); 68 (in seventy and seventy-five minutes); 72 (in eighty and ninetyfive ininutes); 70 (in one hundred minutes); 72 (in one hundred and five, one hundred and ten, and one hundred and fifteen minutes); 76 (in one hundred and twenty minutes); 80 (in one hundred and eighty and two hundred and forty minutes), *. - In five minutes after taking the medicine, his pulse became considerably reduced, both in force and frequency ; in thirty five minutes he had a copious discharge of pale-colored urine, his pulse much increased; in fifty ninutes, very sleepy, pulse again reduced ; in seventy minutes, his mental faculties became much exhilarated, pulse very slow and soft ; in ninety minutes, perfectly free from any peculiar feelings, pulse somewhat increased ; in one hundred and eighty minutes, pulse very natural, -Pulse 70 (before experiment); 52 (in five minutes); 48 (in ten minutes); 46 (in filteen minutes); 42 (in twenty and twentyfive minutes) ; 48 (in thirty minutes); 43 (in thirty-five minutes); 45 (in forty and forty-five minutes); 39 (in fifty minutes) ; 43 (in fifty-five minutes); 46 (in sixty minutes); 50 (in sixty-five, seventy, and seventy-five minutes) ; 45 (in eighty, eighty-five, and vinety minutes); 47 (in ninetyfive minutes); 50 (in one hundred, one hundred and five, one hundred and ten, one hundred and fifteen, one hundred and twenty, and one hundred and twenty-five minutes) ; 53 (in one hundred and thirty minutes); 55 (in one hundred and thirty-five minutes); 57 (in one hundred and forty minutes); 60 (in one hundred and forty-five, one hundred and fifty, one hundred and fifty-five, one hundred and sixty, and one hundred and sixty-five minutes); 65 (in two hundred minutes); 70 (in two hundred and seventyfive and three hundred minutes),67.— In five minutes after taking the med



icine my pulse became diminished, both in force and frequency; in fifteen minutes I felt considerable flushes of heat passing over my face, and followed by a considerable degree of vertigo ; in fifty minutes, my pulse became still more diminished; in sixty-five minutes, I was somewhat sleepy; and in seventy-five minutes, I was very sleepy, attended with a slight diaphoresis ; in one hundred and thirty minutes

, my pulse began to increase in frequency, but continued diminished in force; and in two hundred and thirty-five minutes, was natural, both as to force and frequency,'.-Pulse 160 ; grew feeble (after a few hours),9%.

Superior E.ctremities.-Numbness in the arms," --[1220.] In a few seconds his fingers changed color, and took the livid greenish tint characteristic of a corpse in a state of incipient decomposition. After about ten seconds the skin regained its color," :-Cramps of the fingers, *.

Generalities.-Convulsions, -Extreme prostration, suffering from excessive nausea and vomiting, with slight purging, heat and burning in the fauces, inordinate thirst, cold, clammy skin, feeble pulse, violent supraorbital pain, and distressing gastralgia, with very anxious countenance, **. --Pale, cold, vomiting constantly, purging, and complaining of great thirst and pain at the epigastrium," – The symptoms were mainly those of violept cholera morbus,96 — Debility,". - Very much exhausted,” – Similar symptoms, but milder, except the headache, which he described as most intense,”

Sleep.-Insomnia, Fever:-[1230.] Shivering,9. —Coldness,95 - Whole body clammy and cold,"%-Feet and hands cold,.-Cold sweat on forehead,"





COLLINSONIA. Authority. 2, M. M. Dowle, M.D., U. S. Med. Invest., N. S., 3, 1876, p. 386, took a teaspoonful and half of the powder.

After about half an hour, while partaking of warm mashed potatoes and hot sweetened milk, at supper, I first experienced a warmth in my lips, and simultaneously a tensive, pressive headache at the point of emergence of the supraorbital nerve of the left side. Pressed with thumb over the spot to relieve the aching. Presently, say perhaps ten minutes later, headlache was no longer noticed, only an increasing warmth spreading along the internal mucous surfaces of the upper and lower lips; the sense of warmth was deepening rapidly into a feeling of largeness of the parts, attended with a sensation as if the parts were occupied with innumerable needles, which were darting back and forth.

The face, as the cheeks, the forehead, and also all the hairy parts of the under chin, from ear to ear, and thence reflected down almost to breastbone, seemed to feel the same numbness or needlelike darting to-and-fro sensation. Strangely enough, the tongue did not share the same sensations. (There was a caustic sensation in the fauces, which induced some coughing and spitting when the powder was first swallowed, but there was no universal burning in the throat-pit or gullet at any time afterwards.) While the inner surface of the lips, as well as the whole buccal mucous cavity were experiencing au intensity of excitement, the face seemed to grow broader and broader, making the prover feel, in humorous phrase, as if he had a touch of the “ bighead.” The mind partook of the sense of pleasurable exhilaration.

Next, the entire right forearm, from the elbow to the tips of all the fingers, felt the sense of numbness, a weary heaviness ; then the left arm and its fingers. The balls of the two thumbs were very numb; they were worse than the fingers. Rested my head at supper-table on my left hand. Felt a sense of nausea, and thought I must vomit. No better in the open air. Lips seemed growing larger all the while, and mouth seemed to stand open like a huge catfish's; lips dry; no flow of saliva at any time during the proving

Lay down on bed with coat and boots off, with a blanket as covering ; lay there from five to ten minutes ; mouth tingling and burning; lips “enlarging;" face flushing and pricking, and whole head seeming to take on "growing" dimensions; both arms, from elbows to finger-tips, "fast asleep," and hands feeling as broad and heavy again as they naturally were. Wanted to lie with head high, to get more air; suddenly, low down in left lung, felt a gurgling, followed by an inmediate desire to cough, which I restrained, because just three weeks from this date the prover bad a slight attack of hæmoptysis coming from that side, which was checked with Trillin. Uneasy; got up in stocking-feet and shirt-sleeves, and sat near stove. Was, if possible, growing worse. Head seemed to grow bigger while straining to get boots on ; went to front door, and staggered against the large elm tree near the step. While closing shutters felt sick and faint, and re-entered house. At no time did there seem to be any striking departure from a natural breathing; the breathing and pulse did vary, however, while lying down; the pulse under the finger would withdraw like a thread, and then return with more volume. This condition of my pulse was noticed while lying on my left side, recently affected as stated, and I got up to avoid, if possible, a return of that trouble. Hot things taken into the mouth and swallowed, seemed at all times to intensify the effects of the medicine. Had I taken the medicine by mistake in the dark, I would have compared the sensations experienced to those of Aconite; it seems the analogue of Arum triphyllum also. To antidote the Collinsonia action I employed Chloride of sodium; the spirits of Camphor containing Laudanum was used by olfaction, but the mucous membrane of the nostrils, as far within as this volatile stimulant penetrated, seemed only to resent its presence by inducing an unwelcome aggravation of the existing local troubles. Nux vom. wus the antidote. The face returned to a feeling of. naturalness with each dose; the Collinsonia eflects seemed to pass away like a vapor or aura from above downwards; it was felt to move; the sensations of relief being first felt in the forehead; then the cheeks lost their grotesque unbecomingness, or largeness; next the lips parted with their pungent glow, while the two arms, down to their finger-tips, were next severally alike bettered. However, the balls of the thumbs persisted in their numbness, the right feeling somewhat unnatural even the next day. To restore the thumbs and fingers to their right feeling, I slapped my outspread hands at the time across and around my sides, as the wood-chopper does when his hands are numb with cold.

These toxic sensations lasted fully three hours, say from 6 to 9 P.M. Feeling “well ” at this latter hour, I visited a lady patient, a block from my dwelling. In the cool, open air, walking, my feet and limbs felt strangely light, like a deer's, and as though I could run very fast if chased. I seemed to lose the sense of physical or personal identity, as far as the lower extremities were concerned. Returning home, after an absence of perhaps ten minutes, I now felt for the first time a strong glow in the


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