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Respiratory Organs.--Breath quick and catching, 16. —Coughed incessantly the whole night (first night),

Pulse.At 9 P.M., the pulse of the left side was gone; on the right side thready and soft (second day),

Generalities.--Slight twitchings of facial muscles. After midnight severe convulsions set in, more like tetanus; throwing the head backwards, eyes rolling about, countenance distorted, body sometimes nearly curved, with legs turned back. At intervals grasping at everything; gnawing of fingers. Burning pains apparently torment her, as she forces everything in her mouth. After four convulsions she died about 2 A.M. (second night),16

- Very restless ; throws herself about with her whole body from one side to the other,&-Collapsed, the face pinched, extremities rather cold, great restlessness, drawing up of lips over the teeth, with pinched expression of mouth and pose,'.

Fever.- Hot perspiration on occiput; clammy in forehead. The icycold clammy perspiration crept steadily upwards,


CINNAMOMUM. Authority. 2, C. G. Mitscherlich, Pharm. Journ., vol. ix, 1849, p. 233, effects of large doses.

Diarrhea,'. - Increased secretion of urine,?:-Excite the vascular system and the respiratory organs,'.

CITRIC ACID. Authority. W. Stevens, On the Blood, p. 451.

During a residence of twenty years in the West Indies I have only seen one case of scurvy, and that case was decidedly brought on by the excessive use of Citric acid, which an American gentleman had been recommended to use as a preventive against the yellow fever.

CITRUS LIMONUM. Authority. 3, G. O. Rees, experiments on a healthy man with 1 ounce lemon-juice, three times daily for three days (Treatment of Rheumatic Diseases by Lemon-juice, pp. 32–37), Edinb. Med. and Sur. Journ., vol. i, 1850, p. 241.

[10.] Pulse naturally full, and 75 in the minute. After five doses it became much weaker and more compressible, and numbered 70 in the minute; conditions accompanied by a feeling of general depression. Pulse 66, and very small and compressible (third day). Feeling of general depression (with weaker pulse). Urine always acid, and also natural in quantity till the third day, when it increased somewhat; the sp. gr. was then 1017, with a deficiency in lithic acid,'.


Symptom 364, in vol. iii, copied from Hering's Monograph, begins with “On washing;" in North. Amer. Journ. of Hom., New Series, vol. v, p. 179, first line, it is “On waking."

Authorities. 45, Alex. Cochet, Journ. de Chim. Med. (Amer. Journ, of Pharm., 1833-4), p. 58, effects of chewing, on the Indians of Peru; (46 to 50, Berridge's Collections, Appendix to Brit. Journ. of Hom., general effects); 46, Dr. Martius, from Gauger's Repert., 1842, p. 452 (Pharm. Jouri., 1843, vol. ii, p. 660); 47, Prof. Schlechtendal, from Encyclopædia of Med. Sci. and Archiv. der Pharm., 1853 (Pharm. Journ., vol. xiii, p. 224); 48, Schroff

, from Wien. Wchnbl., vol. xviii, and Schmidt, vol. cxvi, p. 297 (New Sydenham Soc. Pub., vol. xix, p. 453), experiments with Cocaine, its acetate and chloride, and an alcoholic extract of the leaves; 49, Rossi, Roman Correspond. Sci. (Lancet, 1866 ( 2), p. 195); 50, Practitioner, 1868, vol. i, p. 233, Review of Recherches Chim. et Phys. sur l'Erythroxylum Coca du Perou et la Cocaine, by Thomas Moreno y Mais, Paris, 1868; (51 to 55, Edward Lippman, Thèse Etude sur la Coca du Perou, Strasbourg, 1868); 51, effects of hot infusions of 1 to 15 grams to 60 of water; 52, effects of 30 grams; 53, extract of 2 grams; 54, obs. of Rossier, effects of chewing 1 to 3 grams of the leaves ; 55, Mr. Reis, chewed the leaves ; 56, l'Union, No. 91 (New Sydenham Soc. Pub., vol. xix, 455), (Berridge), effects of leaves ; 57, Scrivener, Med. Times and Gaz., 107 (2), p. 407, effects on chewers; 58, Berridge, North. Amer. Journ. of Hom., New Series, vol. v, 1874, p. 165, Dr. David Wilson, inbaled the vapor while potentizing about 3.30 P.M.; 59, E. B. Shuttleworth, Can. Pharm. Journ., Aug., 1877 (Pharm. Journ, and Trans., vol. viii, 1877, p. 221), effects on the Toronto Lacrosse Club.

Mind.-Its effect is to deaden sensation and produce even madness,". -In large quantities the chewing of leaves induces a state of intoxication, like that of Cannabis,56. -- Animation and content,57.— When chewed in large quantities, the Coca causes a kind of intoxication and loss of sleep,“.

- The head felt agreeably light, the ideas flowed with facility, and fantastic images followed each other in rapid succession ; this was soon succeeded by extreme drowsiness, in resisting which there was great oppression of the head and confusion of thought. If he had given way to it the prover felt he would have passed into an agreeable dream life, like that produced by Cannabis. The effect of the drug varies according to the intensity of the effort made to resist it. As soon as the interference with consciousness ceases, and the relation between the mind and the external world is reestablished, all the other functions return to their normal state, 48.

Head.-Heaviness of the head," - Always after chewing the leaves sleep was quiet, but the next morning there was frontal headache, which lasted a part of the day; at the sanie time the tongue becane coated and the appetite impaired, **

Eye.-Eyes brilliant,57—[520.) After large doses of the decoction, there is dilatation of the pupils, and physical mental calm,".

Ear.-In half an hour, distant ringing booms through head, repeated twice, once in evening, lasting a few seconds, S.

Nose.—About midnight, on going to bed, pose felt swollen and stuffed, like an incipient catarrh (first day),

Face. -Countenance more animated,"7 – Paleness of lips,"? - Slight yellow tinge about angles of mouth,.7.

Mouth.-Teeth stained bright yellow,57.-It increases the secretion of saliva, produces a sensation of warmth and fulness in the mouth and stomach, and stills hunger,".-Diminished saliva, "4.

Throat.-Some dryness of the throat, *. - [530.] Heat and dryness of the throat,

Stomach.-It enables the workmen to endure prolonged abstinence, 56.


- Men may live in robust health several days without food. Rossi, after taking a decoction of the leaves, felt neither hunger nor thirst for fortyeight hours,"o: —They appear as if they had partaken of a rich repast,“ :An agreeable heat; a sensation of confort in the epigastrium, somewhat like that produced by a glass of wine, radiating from the stomach over the whole body,

Respiratory Organs.-Enables them to ascend heights without dysppea,“.

Pulse.—Pulse strong and frequent,"? - The pulse from the first gained in frequency and strength, while the breathing lost in frequency, but became deeper and fuller,4% — Pulse 59 (before taking); 63 (after five minutes) ; 56 (after fifteen minutes); 61 (after forty-five minutes),S.

Superior Extremities. -A warm indistinct pain in left shoulderjoint, for a few minutes, at 12.30 P.M. (second day), 58.

Generalities.-510.) Tetanic convulsions, hyperästhesia, dilated pupils, and diminution of movements from loss of co-ordination,. -Abuse of Coca causes signs of premature old age, unsteady step, yellow skin, want of brilliancy of eye, and general indifference or apathy,97-General symptoms like those produced by a small quantity of alcohol, a slight disturbance of vision, slight increase in the frequency uť the pulse; cold infusions produced the same effects,"?-Sustains the strength, --Desire for physical exertion,57—Great feeling of comfort,"9: — More agility in walking, * -Increases the bodily activity,"7.—The effects of small doses seems to be to resist fatigue, which I frequently noticed in long walks," —When provided with Coca, they (the Peruvians) can make rapid journeys, without suffering in their respiration, and can take unremitted exercise without being worn out by fatigue. They have been known when acting as guides, to travel twelve or fourteen leagues without stopping, and to perform this as rapidly as the best mounted horseman. This arises from the circumstance, that in these elevated regions, horses soon suffer in their wind, and hence gradually relax their speed; whilst, on the contrary, the Indians, by constantly using the Coca, do not thus suffer, and always keep the interior of their mouth in a moist state. The inhabitants of the country support all kinds of fatigue, for two or three days, without any other stimulant than the Coca, [550.] At the commencement of the match, about 1 drachm to 1 drachms of the leaves was served out to each man. This was chewed, in small portions, during the game, the saliva being swallowed. On first taking the leaves, a sensation of heat and dryness was produced in the throat. This was relieved by washing out the mouth, or gargling with water, after which the desire for water was no greater than usual. Soon after a sensible augmentation of force, and a general feeling of invigoration were realized, and continued to be felt throughout the game, so that fatigue was wholly, or in great part resisted. The pulse was observed to increase in frequency, perspiration was augmented, but no mental effect was noticed, save the exhilaration of spirits always attendant on the exercise of well-strung muscles and ou the excitement of play,... — Torpor, 52-General feebleness, -It produces, in large quantities, lassitude and drowsiness,"7—The first effects are succeeded by a profound calm, a kind of paresis, during which one does not wish to use the faculties, and is overpowered by indolence,".

Skin.-While writing a long letter, about 8 or 9 P.M., felt in left groin and region of abdominal ring as if the skin were sore and sinarting ; it felt a little tender to touch. (Here he formerly had an extensive glaudular suppuration several years ago, from cold and fever), (first day),


Sleep.-Slept remarkably well last night; dreaming that something was adhering to fauces at posterior entrance to pares which he was trying to detach ; woke about 8 A.M., actually in the effort, and there really was mucus there to detach; still has the smarting soreness (second day),*

Ferer.-Increase of subjective warmth," --Coldness of the extremities,".-General perspiration,".—[560.] Cutaneous secretion rather diminished,

CODEINUM. Authority. 11, C. Ambrosoli (Gaz. Lombardo, 1875), Brit. and For. Med. Chir. Rev., 1876, p. 235, poisoning of a child, aged two years.

Face pale, extremities cold, pulse small, abdomen distended with flatus, eyes glassy and immovable,".

COFFEA TOSTA. Authority. 9, Dr. Curschmanu (Deutsche Klinik, No. 41), Med. Times and Gaz., 1873 (2), p. 584, additional symptoms ; 17, Dr. Eust radiadis, Etude Exper. sur les Prop. Phys. de la Cafeine et du Cafe, Paris, 1870.

Mind.-She recognized those about her, and was aware of the cause of her sufferings, but still her sensorium was evidently not quite clear; and next day she retained only a very obscure recollection of what had occurred. Plain or connected answers were not obtainable from her, and only after much effort and persuasion would her 'attention be engaged at all, she continuing to incessantly repeat the same phrases in the most dolorous tone,'.

Eye.-The pupils somewhat enlarged, acted normally,'.

Stool.-In one hour severe diarrhea, which continued to recur about every half hour for long afterwards,"

Urinary Organs.-Frequent desire to pass urine, which came on every quarter of an hour. The urine having a specific gravity of 1014, was considerably increased in quantity,'.—The general conclusions were that there was great diminution of urea, over 15 per cent. Coffea did not prove a diuretic, though there was increased frequency of micturition,"

Respiratory Orgams. - Respiration painful, short, and rapid, counting from 24 to 30,".—Complained of want of air, and a sensation as if her chest were compressed, and clung convulsively to articles of furniture or the persons near her, but sinking down again quite powerless,'.

Heart and Pulse.-[160.) Distressing palpitation, and the impulse seemed almost to raise the chest,".-Pulse 112,9.

Extremities.—The limbs, and especially the hands were affected by chorealike movements, so that the patient was unable to hold either a glass or spoon,


Ferer.-The forehead was cold, and the temperature of the other parts of the body did not seemed raised,'.

COFFEINUM. Authority. 5, Dr. Kelp, Memorab., 22, 1877 (S. J., 176, 220), a woman took two powders of the citrate, each containing 0.24 gram.

She was seized with remarkable restlessness and dizziness, and could not keep erect. Violent præcordial anxiety, palpitation. Abdominal pulsation. Violent trembling of all the extremities. Grating of the teeth. Features expressive of the greatest anxiety. Feeling of constriction of the neck and throat, recurring periodically every fifteen minutes. Pulse very rapid. This condition lasted three hours, and gradually disappeared,'.


Authorities. 86, J. Y. Clark, M.D., Am. Med. Rec., vol. i, 1818, p. 369, John R. Peckworth took 100 drops of tincture; 87, ibid., the author took 100 drops ; 88, Thos. Kennard, M.D., Am. J. of M. S., 1857 (1), p. 69, a woman, æt. fifty-six years, took one ounce of Colch. wine in twelve hours ; 89, Dr. Fifield, Bost. Med. and Surg. Journ., vol. Ivi, 1857, p. 78, a man, æt. twenty eight years, suffering from rheumatism, took half an ounce of Colch. wine ; 90, W. A. Hammond, M.D., Am. Med. Monthly, Feb., 1861, p. 83, took 1 fluid drachm at 8 A.M., 2 and 10 P.M. (first day); 1} fluid drachms three times (second and third days); } drachm (fourth day); 1} drachms (fifth day); 91, ibid., a man, æt. twenty-three years, took 1 drachm tincture three tinies (first day); 1} drachms three times (second day); 92, John H. Garner, M.D., Canada Lancet, vol. iii, 1871, p. 307, R. H. drank about a pint of tincture ; 93, ibid., J. M. J. took same quantity ; 94, ibid., T. H. took a small quantity ; 95, W. E. Porter, Med. Times and Gaz., 1874 (2), 723, poisoning of two children, æt. four and two years ; 96, Canada Pharm. Journ. (Pacif. M. and S. Journ., April, 1874, p. 572), a party of seventeen persons drank from one or two ounces to a pint each, of the wine, seven died; 97, J. Pierre, Comptes Rendus, vol. lxxix, p. 633 (Pharm. Journ. and Trans., Oct.

, 1864, p. 325), the author plucked some fully expanded flowers, afterwards extended his hand over a large clump of Howers, carefully avoiding all contact, with the same result.

Minil.-Muttered and raved wildly at times, but it only lasted a few minutes,9..—Comatose, 92.

Head.—[1190.) Intense headache, 92.
Eye.-Eyes red and watery, and the pupils dilated,"?
Ear.--Much tinnitus aurium,

Face.-Expression of countenance anxious and haggard,"? – Hectic flush occasionally on cheek-bones,"?.

Mouth.Touguedry and brown in the centre, and red along the edges, 92.

Stomach.-Great thirst,92 95. — Nausea," —Sickness,95 – Vomiting in from three-fourths of an hour to an hour and a half,06 --[1200.] The ejecta were bilious, and then of the rice-water character, 26.

Abılomen.-Extreme tenderness over abdomen, and the intermittent severe pains precisely similar to peritonitis,9%-Tormina,%.

Rectum and Anus.— Tenesmus,%.

Stool.-Purging, *6.-Severe diarrhea (second day),". – Purged and vomited violently,"? --Purging in from three-fourths of an hour to an hour and a half, when a large quantity was taken ; later when the quantity was small,96

Urinary Organs.-In three days immediately preceding commencement of experiment, the average quantity of urine for each day was 1425 cubic cent. of 1021.73. The average amount of solid matter was 64.28 grams; of which 30.18 were inorganic, and 34.10 organic substance. The


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