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-[50.] Thinks it a very penetrating medicine,':- Feels like fainting," :Whole system utterly relaxed, no strength, no vigor, :-Pains as in all the bones,

Skin.-A great deal of inflammation, which continued for six or eight days, accompanied with intolerable itching in the part, and succeeded by desquamation ; this was considerably different from the vesication produced by Cantharides ; for besides that the cuticle was very little raised with water, the inflammation extended to a much greater distance round the part, and the next day the blister was circunscribed with an eruption, which continued to increase for some time, having very much the appearance of a ringworm,'.

Sleep.-Continued to be drowsy, with very weak feeling in head,".

Chill.-Chill seems all over, flesh quivers,'.- As if blood on fire," Exceedingly hot, as of blood boiling, but cannot sweat; skin feels dry,'. Blood as if heated, with prickling,'. - [60.] Hot flashes,':- Feet burn,'.


Authority. 76, John M. Walker, Inaug. Diss., Phil., 1803, experiment on pulse.

One grain pulv. Cort. per. rub.: Pulse 66, natural, on taking ; no change (after five minutes); 67, full (after ten and fifteen minutes); 68, full and tense (after twenty minutes) ; 69, full and tense (after twenty-five and thirty nuinutes); 70, full and tense (after thirty-five minutes); strong and regular (after forty to seventy minutes); 71 (after forty-five and fifty minutes); 72 (after fifty-five and sixty minutes); 71, slight headache (after seventyfive minutes); 70, full (after eighty-five minutes); 68, full (after ninetyfive minutes ); 67, nearly natural (after one hundred and five minutes).

12 grains of resin of P. bark : Pulse 64, natural, on taking; full and regular (after five to twenty-five minutes); 65 (after ten minutes); 66 (after fifteen minutes); 68 (after twenty and twenty-five minutes); full and tense (after thirty to forty-five minutes); 68 (after thirty minutes); 69 (after thirty-five and forty minutes); 70 (after forty-five minutes) ; regular (after fifty to sixty minutes); 71 (after fifty minutes); 72 (after fifty-five and sixty minutes); full, face flushed (after sixty-five to eighty minutes); 73 (after sixty-five and seventy minutes); 70 (after seventy-five minutes); 66 (after eighty minutes) ; 65, diminished in fulness (after eighty-five and ninety-five minutes).

12 grains extract of P. bark. Pulse, 66, natural, on taking ; 60, full and strong (after five minutes); 67 (after ten minutes); 68 (after fifteen minutes); 69 (after twenty to thirty minutes); full (after thirty-five to sixty-five minutes); 70 (after thirty-five and forty minutes); 72 (after forty five to fifty-five minutes); 71, full and tense (after sixty minutes); 70, full and tense (after sixty-five minutes); 68, diminished in strength (after seventy-five minutes) ; 67 (after ninety-five minutes).

12 grains gum of P. bark: Pulse 72, natural, on taking; no change (after tive minutes) ; 73, fuller (after ten minutes); 75, fuller (after fifteen and twenty minutes); tense (after twenty-five to thirty-five minutes); 77 (after twenty-five minutes); 78 (after thirty minutes); 80 (after thirty-five minutes); fuller and stronger (after forty to fifty-five minutes); 81 (after forty minutes); 82 (after forty-five to fifty-five minutes); full (after sixty to seventy minutes); 80 (after sixty minutes); 79 (after sixty-five minutes); 76 (after seventy minutes); 75 (after seventy-five minutes).

2 ounces decoction of P. bark: Pulse 72, natural, on taking; 62, soft (after five minutes); 63, soft (after ten minutes); 65 (after fifteen and twenty minutes); fulness (after twenty to thirty minutes); 67 (after twentyfive minutes); 68 (after thirty minutes); considerable tension (after forty to seventy minutes); 69 (after forty minutes); 71 (after fifty minutes); 72 (after sixty minutes); 73 (after seventy minutes); 71 (after seventyfive minutes); tense, with flushing of the face (after seventy-five to ninety minutes); 77 (after eighty minutes); 69 (after ninety minutes); 66, full (after one hundred minutes).

2 ounces infusion of P. bark: Pulse 64, natural, on taking; no change (after five minutes); 66 (after ten minutes) ; 68 (after fifteen minutes); 69, fuller (after twenty minutes); 70, fuller (after twenty-five minutes); 72 (after thirty minutes); tension increased (after thirty to fifty minutes) ; 73 (after forty minutes); 76 (after sixty to seventy-five minutes); full and tense (after sixty to eighty minutes); 74 (after eighty and eighty-five minutes); full (after eighty-five and ninety minutes) ; 73 (after ninety minutes) ; 66 (after one hundred minutes),16



Authorities. 55, C. Robbins, M.D., Bost. Med. and Surg. Journ., vol. xxxiii, 1850, p. 560, Mr. O., æt. thirty years, took half a drachm; 56, Chas. E. Slocum, Med. Rec., vol. xii, 1877, p. 334, effects on three ladies; 57, Prof. Köbner, Berlin, Klin. Woch., 1877 (Med. Rec., 12, p. 601), effects on a large, powerfully built woman, æt. twenty-eight years; 58, Prof. Köbner, Berlin, Klin. Woch. (Gaz. Med., Paris, 1877, p. 590), a patient, suffering from facial neuralgia, took 1 gram. 59, Dr. Ricklin, Gaz. Med. de Paris, 1877, p. 590, a young woman, suffering from bronchitis, took a powder ; 60, Henry M. Field, M.D., Lond. Med. Rec., vol. xiv, 1878, p. 427, effects of ordinary allopathic doses on a lady for chills and fever ; 61, John S. Linsley, M.D., MSS., took at one dose 30 grains at vight.

Great nervous excitement, with wakefulness all night. Sensation in auditory region, as if a horse railroad, with its continual roar and rumble, had its course through the brain incessantly ; worse alternate days for one week,“.—In about three-quarters of an hour he began to feel as if intoxicated; this feeling, which was precisely similar to that produced by an overdose of alcohol, increased so rapidly that in about fifteen minutes his ideas became confused, and he was unable to walk without staggering ; the next morning he complained of loss of appetite, dull pain, and dizziness of the head, and a general languor and debility, and incapacity for business, % She said that it poisoned her; “It is as if every drop of blood and every tingling nerve were in my skin.” There was great heat, ædema in some places, especially in face and hands, great iucrease of cutaneous sensitiveness; all followed in a few days by desquamation of the cuticle. With these accidents were associated more or less gastric disturbance, and upon one occasion violent and repeated vomiting, headache, and delirium. Even 4 to 5 grains Sulphate of quinine for the twenty-four hours produced a light attack of the skin disease, enough to suggest alarming results should the usual 1 to 3 gram doses be prescribed, “0. — After two hours she was taken with internal chills, followed by very violent præcordial anxiety, with uausea and vomiting of mucus. İn a few minutes the patient complained of very violent headache, accompanied by repeated chills, followed by a sensation of burning heat, especially in the head, and then over the whole surface of the body. On the next morning the fever was intense, and there was an exanthematous eruption, associated with burning heat and distressing itching. The patient also complained of difficulty of swallowing and cutting pains in the throat. The redness extended over the face, neck, shoulders, back, and limbs, and disappeared on pressure. The skin was very sensitive to touch, especially about the throat. There was oedema of the lids. The redness finally appeared on the extremities, where, however, it was not continuous, but in isolated patches, especially upon the anterior surface of the extremities. On the posterior surface of the thighs there was a series of papules very prominent, scattered, surrounded by a red areola. The posterior portion of the pharyox was deep red. The tongue did not present the usual characteristics of scarlatina, and on consultation it was decided that the symptoms were due to the Chinin., analogous cases baving been seen by the consulting physician. On the ninth day intense desquamation commenced and lasted three weeks. The temperature was high during the first days, 39.8° C., pulse 124. Some time afterwards this patient had another attack of bronchitis, and took Chinin. again, which was followed by the same symptoms, but in a less violent degree. Desquamation commenced on the fifth day, on the palms and soles, and lasted three weeks, 59. —[1080.] She was attacked with a syndrome, closely resembling that of scarlet fever, whenever she took even a small dose of Quinine. The symptoms consisted in a chill, which was sometimes repeated, a feeling of præcordial anxiety, nausea, vomiting, intense headache, high fever, and angina. A few hours after the chill an erythematous eruption made its appearance on the face, and spread rapidly over the entire body. It was attended by intense burning and itching, by slight edema of the face, and injection of the conjunctiva. The color disappeared for a moment on pressure. The eruption on one occasion completely covered the entire body; on another it was confluent on the upper part of the body, but discrete on the legs. On this occasion the eruption on the legs was slightly papular, and the lower border of the confluent part was not sharp, but gradually faded into the healthy skin. After a variable length of time, according to the amount of Quinine taken, the symptoms abated and desquamation began. The angina affected only the posterior wall of the pharynx, the soft palate and pillars being normal. Three times in the course of five months the patient was seized with these attacks. The first time the exanthem broke out after 39 grains of Quinine had been taken. As a diagnosis of scarlet fever was made, the Quinine was continued for eight days, and the eruption persisted for the same length of time. Desquamation then began, and continued for six weeks, and on the soles of the feet, in fact, for nine weeks. The fever was high and persistent, and the prostration was very great. Three months later the exanthem reappeared after a dose of 2 grains of Quinine. The stage of eruption lasted four days, and the desquamation ihree weeks. The third time the exanthem made its appearance after a dose of only 14 grains of Quinine. The stage of eruption lasted only two and a half days, and the desquamation fourteen days. The affection this time ran a wilder and shorter course thau on the two previous occasions. Dr. Von Heusinger, of Marburg, states that he has

met with two cases, in which symptoms entirely analogous to those described above, were produced whenever even very small doses of Quinine were administered. In these cases, however, the eruption was confined to the face. Both patients were women. One of them was at one time able to take Quinine without inconvenience,"?:-I have had three patients, all ladies, with whom Sulphate of guinive has produced peculiarly unpleasant effects. Very soon, usually within half an hour, in oue case almost immediately after the medicine was taken, the face became suffused with an erythematous eruption, and a tingling-itching sensation, very severe and distressing in its nature, followed and extended over the body and extremities. The effects produced in the three cases varied somewhat, but mainly were identical with the symptoms of urticaria ab injestis. In case first, I have at long intervals prescribed the various preparations from the bark unknown to her, and invariably with the same result, the less active preparations being the more slow in their effect. In this case nausea, vomiting, and great gastric distress followed the cutaneous irritation. In case second, there was produced considerable ædema, with wheals, ending with desquamation. In case third, the cutaneous eruption and irritation were not so severe as with the others, but the pulmonary oppression and constriction of the throat were the more prominent symptoms, 56. —On the same day there developed a scarlatina-like eruption over the whole body, with very high fever, delirium, dyspnea, and all the symptoms of pulmonary congestion. Scarlatina, with pleuro-pneumonia, was diagnosticated. The eruption disappeared on the fourth day, and was followed by desquamation, which lasted three weeks,"

Chionanthus virginica, L.
Naturul order, Oleaceae.
Common name, Fringe tree.

Authority. Dr. Scudder, Eclectic Med. Journ., May, 1876, (U. S. Med. Invest., N. S., 3, 1878, p. 562).

In good health, except some derangement of brain, taking the form of aphasia. Took 30 drops of a strong tincture at 1 P.M. ; at 2.30 P.M., sensations of contractions in the stomacch, as if some living thing was moving in it, with uneasy sensations in the region of the liver, and occasionally in the region of the spleen; rheumatic pain in left ankle and tarsal bones. Unpleasant sensations in the stomach and hypochondria increase, and at 3 P.M. they have become very annoying ; sensation like spasms, or palpitations of the heart, in the stomach; uneasy sensation in the region of the sigmoid flexure, as if caused by flatulence; uneasiness in right hypochondrium, extending to the left iliac region; tongue coated yellow in the centre, previously clean ; pulse markedly smaller and weaker; rheumatic pain in left carpo-metacarpal articulation of left thumb; evacuation of bowels at bedtime of black, tarry-looking fæces. Slept well; on waking had pain for a short time in the spine, from the seventh to the tenih dorsal vertebræ. The head was remarkably clear for a few hours, and all the symptoms of aphasia had disappeared (unfortunately they returned the next day, though not so bad). The sensations in the region of the stomach, liver, and spleen were so marked that no one could mistake the locality of the action, or the certainty of the action. I gave it to Mr. G. with about the same result, and to Mrs. N., who found a single dose of 10 drops produce all the sensations named in so unpleasant a form, that she could not be induced to repeat the remedy. In the last case there was a feeling as if the bowels were about to move off violently, from the action of a purgative, with the nausea usually associated with such an action, though there was no discharge from the bowels.


Authority. 25, M. Donné, Lancet, 1834–5 (2), p. 737, a girl, æt. nineteen years, swallowed a glass of a solution of Chlorine.

Immediately seized with severe vomiting; the tongue became dry and red; she had slight fever, and the epigastrium was somewhat sensitive to touch; the saliva was strongly acid,"

CHROMICUM ACIDUM. Authority. 7, H. Wardner, M.D., Phil. Med. and Surg. Rep., vol. xx, 1869, p. 362, a man, æt. thirty-six years, took a solution containing about 15 grains.

His features contracted, his countenance assumed a leaden hue, and his eyes sauk (within three minutes); countenance partially resumed color (after two hours),':-Vomited very profusely; first the contents of the stomach, then a large quantity of bile; and lastly, considerable blood (within three minutes); stomach still irritable (after two hours),-Great burning pain in stomach (after two hours),. -- Two or three copious alvine dejections (in three minutes),'.


An organic acid obtained from Rhubarb and some lichens (Parmelia, Squamaria, etc.). Authority. J. Ashburton Thompson, M.D., Brit. Med. Journ., 1877 (1),

Deductions from 319 observations ; 206 of these were on persons who were out of sorts rather than ill.

The crude powder and the extracted acid have the same locally irritant effects ; either kept in contact with the skin produces irritation, inflammation, and discoloration of the cutis. Either introduced in minute quantity to the eye causes conjunctivitis.

p. 607.

On reaching a dose of 6 grains, I experienced sensations of nausea, accompanied and followed by sensations of disturbance in the bowels; even an abortive attempt at vomiting; then relief from all symptoms (after four hours). Sensations of disturbance in the bowels, accompanied and followed the sensations of nausea (after four hours). A loose action of the bowels (after twenty hours).

My brother dined at 7; at 8.30 he took 8 grains of C. made into a pill with confection of roses.

Vomited (after two hours); aroused from sleep by another attack of

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