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shook me cordially and firmly by the hand, and then took his seat. In about a minute he arose, solemnly came forward and again shook hands with me, so that by twenty minutes he had shaken hands with me as many times. He then began to wash his hands, and though the basin contained no water, he went through the form of using soap and wiping with a towel as often as a dozen times in one hour. Many acts of similar import might be offered, some of which I observed and others were described by members of his family. I joined the patient at tea for the purpose of watching what up to this time had been to me an unsolved mystery. He appeared to relish his food, taking singly tea and bread. Towards the close of the meal, while grasping a fragment of bread, there was a distinct spasm of the right forearm and hand. His fingers were firmly clenched, and his hand forcibly flexed on the forearm. He was assisted to his room, his walk entirely natural, and when being placed on his bed he showed some resistance in striking at me. He at once commenced to groan, draw himself up, and tossed from side to side of the bed, suggesting abdominal distress. He soon became unconscious, and from his movements in bed it was clear that he was paralyzed in the right arm. This member was dragged helplessly after him, as my attention was first called to it by a looker on. The next day there continued impairment of motion and sensation of the right side, together with insensibility to touch of the right eyeball. During the third day there were frequent twitchings and stiffness of the right limbs, these culminated in a unilateral convulsion at daylight on the fourth day. At about noon of the third day he passed, as he continued to do to the end, except when drawn off, a large quantity of urine involuntarily in bed. In the afternoon the heavy breathing, with flopping of the cheeks, of apoplexy appeared. There was also more or less constant regurgitation of yellow frothy material from the mouth, which like the evacuation from his skin smelled of wormseed. The accumulation of this material would at times be so profuse as to enabarrass respiration. During one of the attacks of dyspnea, and while in a drenching sweat, which suggested the approach of dissolution, he was gently turned in bed, immediately a general convulsion, markedly opisthotonic, appeared, lasting about two minutes, despite the use of chloroforin. By this time a decided icterus appeared, which had been only noticed the day before. He died about five days from the beginning of his illness in a profound coma, and with a high temperature in his axilla,..



Authorities. (2 to 4, Essay by John S. Mitchell, Philada., 1803.) 2, W. M. Walmsley took 40 grains of fresh leaves of P. mac. at 10.30 A.M. (pulse 80); 3, Dr. A. Gregy, Jr., took 55 grains of same plant, with no effect; 4 grains of fresh leaves of P. umbel., after twenty minutes 20 grains more, pulse 70, at 1.30 P.M.; 3 a, same, took 25 grains at 11 A.M., pulse 72; 3b, same, took at 9 A.M. 30 grains, pulse 76; 4, Dr. Mitchell applied the bruised leaves of P. mac., wet occasionally with vinegar, to one arm, without result, as when given internally; at the same time applied P. umbel. in same way to the other arm; 5, H. P. Gatchell, Am. Hom. Obs., vol. xiii, New Ser., 3, 1876, p. 73, proving of P. rotund. ; 6, H. P. Gatchell, Am. Hom. Obs., vol. xiii, New Ser., 3, 1876, p. 75, proving of P. mac.; 7, ibid., another proving



Mind.Very nervous, cannot bear anything at all; hot, irritable, restless ; thinks diseased state of the blood irritates the skin, as before the eruption of erysipelas, scarlet fever, or measles; itches terribly, 1-Melancholy, :-Stupid and sleepy,':- Becomes partially unconscious, feels like fainting, as if brain paralyzed, mind gone,

Head.-Some dizziness in the head (after seventy minutes),34. —Head heavy, feels as if he would fall down on it," —Wants the head pressed,': – Slight headache (after forty minutes), • --Headache, with pain in the bowels,':-[10.] Feeling of weight, as if in brain, along the brow,'.-Sharp pains and heat in interior of bead, unfitting for exertion,'.—Pain in and above the forehead,'. - Dull heavy pain in the whole front and top of the head, 9. — Pain over right eye,'.

Eye. At first eyes clear, now they burn; lids feel sore,".
Nose-Nose runs,'.

Mouth.-Hollow teeth ache," :--Tongue feels stiff and thick in the middle, cannot raise it,':--Mouth dry,".

Stomach.-[20.] Extreme guawing hunger,':-Slight nausea at the stomach (after fifteen minutes); nausea stationary after repeating the medicine (after twenty minutes),?. - Feels drunk, and as if stomach burnt up with liquor, as if hard, dry, and tough, and as if reunet would be good for it,':- Burning in stomach,

Abdomen.-Sharp pain in right hypochondrium, '.-Liver feels as if enlarged," — Bowels hard and swollen ; thinks the glands are swollen ; bowels very painful, sore, and hard ; feels as if dropsy of abdomen,: -- As if bowels were sore and swollen on right side, ": -Coliclike pains between the pubes and navel,': --Pain in bowels,'.—[30.] Uneasy sensations in his bowels (after one hundred minutes),'.

Stool.-After the colic pains a diarrhea, not very weakening,'.

Sexual Organs.-Aching in vagina, as if labia inflamed, ".-Sensation of swelling in labia, ".-Stinging in labia, as if boils there, *. -Excitement of sexual system,'.

Pulse.-In five minutes, pulse 80; ten, 80; fifteen, 80; twenty, 80; thirty, 79; thirty-five, 79; forty, 80 ; sixty, 80. No increase either in fulness or force,?. --In five minutes, pulse 74; ten, 81; fifteen, 88 ; twenty, 75; twenty-five, 76 ; thirty, 79; thirty-five, 76 ; forty, 74; forty-five, 71; fifty, 71; fifty-five, 70 ; sixty, 65 ; sixty-five, 66; seventy, 69; seventyfive, 66 ; nivety, 64; one hundred and five, 64; one hundred and twenty, 60. Pulse somewhat weaker (after one hundred minutes ), '.-In ten minutes, pulse 66 ; fifteen, 66 ; twenty, 64; twenty-five, 62; thirty, 62; forty, 60 ; tifty, 60; sixty, 62; seventy, 60; eighty, 57; ninety, 60. Pulse fuller (after ten minutes); weak (after seventy minutes),54:- In five minutes, pulse 76; ten, 76; fifteen, 78; twenty, 80; twenty-five, 80); thirty, 80; forty, 78; fitty, 76; sixty, 76; seventy, 72; eighty, 73; ninety, 72; one hundred and five, 76; one hundred and fifteen, 76. Pulse fuller and harder (after twenty minutes),Sh.

Neck and Back.-[40.] Feels as if the neck were too small and tired,':- Needlelike pains in the sacrum,!.

Extremities.-Limbs feel full, as if distended; feeling like that from erysipelas,'-Sensation of swelling in the arm-pits, -Pain from armpit to scapulae,-Right arm as if paralyzed, -Pain in bones of forefinger,':- Needlelike pains in the hip-bones,'.-Legs and arms weak,".

Generalities.-Seems to run all through the blood as a stimulant,".


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—[50.] Thinks it a very penetrating medicine, :-Feels like fainting," :Whole system utterly relaxed, no strength, no vigor,':-Pains as in all the bones,?

Skin.-A great deal of inflammation, which continued for six or eight days, accompanied with intolerable itching in the part, and succeeded by desquamation; this was considerably different from the vesication produced by Cantharides ; for besides that the cuticle was very little raised with water, the inflammation extended to a much greater distance round the part, and the next day the blister was circumscribed with an eruption, which continued to increase for some time, having very much the appearance of a rivg. worm,

Sleep.--Continued to be drowsy, with very weak feeling in head,".

Chill.-Chill seems all over, flesh quivers,'. — As if blood on fire,':Exceedingly hot, as of blood boiling, but cannot sweat; skin feels dry,': – Blood as if heated, with prickling,':-[60.] Hot flashes, ".-Feet burn,.


Authority. 76, John M. Walker, Inaug. Diss., Phil., 1803, experiment on pulse.

One grain pulv. Cort. per. rub. : Pulse 66, natural, on taking; no change (after five minutes); 67, full (after ten and fifteen minutes) ; 68, full and tense (after twenty minutes) ; 69, full and tense (after twenty-five and thirty ninutes); 70, full and tense (after thirty-five minutes); strong and regular (after forty to seventy minutes); 71 (after forty-five and fifty minutes); 72 (after fifty-five and sixty minutes); 71, slight headache (atter seventyfive minutes); 70, full (after eighty-five minutes); 68, full (after ninetyfive minutes ); 67, nearly natural (after one hundred and five minutes).

12 grains of resin of P. bark: Pulse 64, natural, on taking ; full and regular (after five to twenty-five minutes); 65 (after ten minutes); 66 (after fifteen minutes); 68 (after twenty and twenty-five minutes); full and tense (after thirty to forty-five minutes); 68 (after thirty minutes); 69 (after thirty-five and forty minutes); 70 (after forty-five minutes); regular (after fifty to sixty minutes); 71 (after fifty minutes) ; 72 (after fifty-five and sixiy minutes) ; full, face flushed (after sixty-five to eighty minutes); 73 (after sixty-five and seventy minutes); 10 (after seventy-five minutes); 66 (after eighty minutes) ; 65, diminished in fulness (after eighty-five and ninety-five minutes).

12 grains extract of P. bark. Pulse, 66, natural, on taking; 60, full and strong (after five minutes); 67 (after ten minutes); 68 (after fifteen minutes) ; 69 (after twenty to thirty minutes); full (after thirty-five to sixty-five minutes); 70 (after thirty-five and forty minutes); 72 (after forty five to fifty-five minutes); 71, full and tense (after sixty minutes); 70, full and tense (after sixty-five minutes); 68, diminished in strength (after seventy-five minutes); 67 (after ninety-five minutes).

12 grains gum of P. bark: Pulse 72, natural, on taking; no change (after tive minutes) ; 73, fuller (after ten minutes); 75, fuller (after fifteen and twenty minutes); tense (after twenty-five to thirty-five minutes) ; 77 (after twenty-five minutes) ; 78 (after thirty minutes); 80 (after thirty-five minutes) ; fuller and stronger (after forty to fifty-five minutes); 81 (after forty minutes); 82 (after forty-five to fifty-five minutes); full (after sixty to seventy minutes); 80 (after sixty minutes); 79 (after sixty-five minutes); 76 (after seventy minutes); 75 (after seventy-five minutes).

2 ounces decoction of P. bark: Pulse 72, natural, on taking; 62, soft (after five minutes); 63, soft (after ten minutes); 65 (after fifteen and twenty minutes); fulness (after twenty to thirty minutes); 67 (after twentyfive minutes); 68 (after thirty minutes); considerable tension (after forty to seventy minutes); 69 (after forty minutes); 71 (after fifty minutes) ; 72 (after sixty minutes); 73 (after seventy minutes); 71 (after seventyfive minutes); tense, with flushing of the face (after seventy-five to ninety minutes); 77 (after eighty minutes); 69 (after ninety minutes); 66, full (after one hundred minutes).

2 ounces infusion of P. bark : Pulse 64, natural, on taking; no change (after five minutes); 66 (after ten minutes); 68 (after fifteen minutes); 69, fuller (after twenty minutes); 70, fuller (after twenty-five minutes); 72 (after thirty minutes); tension increased (after thirty to fifty minutes); 73 (after forty minutes); 76 (after sixty to seventy-five minutes); full and tense (after sixty to eighty minutes); 74 (after eighty and eighty-five minutes); full (after eighty-five and ninety minutes); 73 (after ninety minutes); 66 (after one hundred minutes),16


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Authorities. 55, C. Robbins, M.D., Bost. Med. and Surg. Journ., vol. xxxiii, 1850, p. 560, Mr. O., æt. thirty years, took half a drachm; 56, Chas. E. Slocum, Med. Rec., vol. xii, 1877, p. 33+, effects on three ladies; 57, Prof. Köbner, Berlin, Klin. Woch., 1877 (Med. Rec., 12, p. 601), effects on a large, powerfully built woman, æt. twenty-eight years; 58, Prof. Köbner, Berlin, Klin. Woch. (Gaz. Med., Paris, 1877, p. 590), a patient, suffering from facial neuralgia, took 1 gram. 59, Dr. Ricklin, Gaz. Med. de Paris, 1877, p. 59 a young woman, suffering from bronchitis, took a powder; 60, Henry M. Field, M.D., Lond. Med. Rec., vol. xiv, 1878, p. 427, effects of ordinary allopathic doses on a lady for chills and fever ; 61, John S. Linsley, M.D., MSS., took at one dose 30 grains at night.

Great nervous excitement, with wakefulness all night. Sensation in auditory region, as if a horse railroad, with its continual roar and rumble, had its course through the brain incessantly; worse alternate days for one week, 1. - In about three-quarters of an hour he began to feel as if intoxicated ; this feeling, which was precisely similar to that produced by an overdose of alcohol, increased so rapidly that in about fifteen minutes his ideas became confused, and he was unable to walk without staggering ; the next morning he complained of loss of appetite, dull pain, and dizziness of the head, and a general languor and debility, and incapacity for business,as. She said that it poisoned her; "It is as if every drop of blood and every tingling nerve were in my skin.” There was great heat, ædema in some places, especially in face and hands, great increase of cutaneous sensitiveness; all followed in a few days by desquamation of the cuticle. With these accidents were associated more or less gastric disturbance, and upon one occasion violent and repeated vomiting, headache, and delirium. Even 4 to 5 grains Sulphate of quinine for the twenty-four hours produced a light attack of the skin disease, enough to suggest alarning results should the usual 1 to 3 gram doses be prescribed, 6. — After two hours she was taken with internal chills, followed by very violent præcordial anxiety, with vausea and vomiting of mucus.

În a few minutes the patient complained of very violent headache, accompanied by repeated chills, followed by a sensation of burning heat, especially in the head, and then over the whole surface of the body. On the next morning the fever was intense, and there was an exanthematous eruption, associated with burning heat and distressing itching: The patient also complained of difficulty of swallowing and cutting pains in the throat. The redness extended over the face, neck, shoulders, back, and limbs, and disappeared on pressure. The skin was very sensitive to touch, especially about the throat. There was adema of the lids. The redness finally appeared on the extremities, where, however, it was not continuous, but in isolated patches, especially upon the anterior surface of the extremities. On the posterior surface of the thighs there was a series of papules very prominent, scattered, surrounded by a reil areola. The posterior portion of the pharynx was deep red. The tongue did not present the usual characteristics of scarlatina, and on consultation it was decided that the symptoms were due to the Chinin., analogous cases havivg been seen by the consulting physician. On the ninth day intense desquamation commenced and lasted three weeks. The temperature was high during the first days, 39.8° C., pulse 124. Some time afterwards this patient had another attack of bronchitis, and took Chinin. again, which was followed by the same symptoms, but in a less violent degree. Desquamation commenced on the fifth day, ou the palms and soles, and lasted three weeks,".—[1080.] She was attacked with a syndrome, closely resembling that of scarlet fever, whenever she took even a small dose of Quinine. The symptoms consisted in a chill, which was sometimes repeated, a feeling of præcordial anxiety, nausea, vomiting, intense headache, high fever, and angina. A few hours after the chill an erythematous eruption made its appearance on the face, and spread rapidly over the entire body. It was attended by intense burning and itching, by slight edema of the face, and injection of the conjunctiva. The color disappeared for a moment on pressure. The eruption on one occasion completely covered the entire body ; on another it was confluent ou the upper part of the body, but discrete on the legs. On this occasion the eruption on the legs was slightly papular, and the lower border of the confluent part was not sharp, but gradually faded into the healthy skin. After a variable length of time, according to the amount of Quinine taken, the symptoms abated and desquamation began. The angina affected only the posterior wall of the pharynx, the soft palate and pillars being normal. Three times in the course of five months the patient was seized with these attacks. The first time the exanthem broke out after 3! grains of Quinine had been taken. As a diagnosis of scarlet fever was made, the Quinive was continued for eight days, and the eruption persisted for the same length of time. Desquamation then began, and continued for six weeks, and on the soles of the feet, in fact, for nine weeks. The fever was high and persistent, and the prostration was very great. Three months later the exanthem reappeared after a dose of 25 grains of Quinine. The stage of eruption lasted four days, and the desquamation three weeks. The third time the exanthem made its appear. ance after a dose of only 1.1 grains of Quinine. The stage of eruption lasted only two and a half dars, and the desquamation fourteen days. The affection this time ran a milder and shorter course than on the two previous occasions. Dr. Von Heusinger, of Marburg, states that he has

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