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but few and trifling. The pulse was not affected in any of the experiments, nor the temperature, except in the third experiment,".

CATALPA.

Catalpa bignonioides, Walt.

Natural order, Bignoniaceæ.

Common name, Catalpa.

Authority. Robert Holmes, Inaug. Thesis, Phila., 1803, p. 29.

Experiment 1.-Two hours after a light breakfast, I took 3 ounces of strong decoction, made with the inner bark of the trunk. My pulse being 70 in a minute, its natural standard.

In five minutes, pulse beat 70 strokes; in ten, 70; in fifteen, 72; in twenty, 74; in twenty-five, 72; in thirty, 68; in thirty-five, 67; in forty, 67; in forty-five, 64; in fifty, 66; in fifty-five, 68; in sixty, 68.

In ten minutes there was no perceptible alteration in my pulse; in twenty, it became rather fuller; in thirty, its fulness increased, and continued so until forty-five minutes had elapsed, when it became smaller and irregular. About two hours after it was taken, it began to operate as a cathartic, and continuing for some time pretty copiously, without inducing nausea or griping. Neither did my body become costive after its operation.

Experiment 2.-Three hours after my usual dinner, my pulse beating 70 in a minute, I took 2 scruples of the extract obtained from the decoction. In five minutes, pulse beat 70 strokes; in ten, 74; in fifteen, 74; in twenty, 75; in twenty-five, 80; in thirty, 78; in thirty-five, 76; in forty, 76; in forty-five, 76; in fifty, 74; in fifty-five, 74; in sixty, 72.

In fifteen minutes my pulse had only increased in frequency; about the twentieth it was diminished in fulness, at which time I began to feel sick at my stomach; in thirty was still smaller, and continued so until the expiration of fifty minutes, when it became irregular and weak. Purgative effects.

Experiment 3.-Mr. T. S., a healthy young man, took a drachm of powdered bark in a small quantity of milk, three hours after dinner. Pulse 72, in a minute.

In five minute, pulse beat 72 strokes; in ten, 72; in fifteen, 70; in twenty, 66; in twenty-five, 64; in thirty, 63; in thirty-five, 62; in forty, 60; in forty-five, 60; in fifty, 62; in fifty-five, 64; in sixty, 66.

About the twentieth minute his pulse was much fuller, with some tension; and continued so without much variation until forty-five minutes had elapsed, at which time it became small and irregular, and he complained of a slight degree of headache, which lasted some time, after which his pulse began to ussume its natural pulsation.

Experiment 4.-At 11 A.M. I took 3 scruples of the powdered bark, diffused in a little milk. My pulse beating 72 strokes in a minute.

In five minutes, pulse beat 72 strokes; in ten, 74; in fifteen, 74; in twenty, 76; in twenty-five, 76; in thirty, 77; in thirty-five, 78; in forty, 76; in forty-five, 76; in fifty, 74; in fifty-five, 74; in sixty, 72.

In ten minutes my pulse became fuller; in fifteen its fulness had increased, and continued so without much variation until the expiration of thirty minutes, when it began to grow weak and much smaller. At this time I felt considerable nausea, which lasted for some time. It, however, went off, and my pulse returned to its natural pulsation.

The same dose was repeated upon a healthy young man, Mr. M. C.
It produced no other effect than an alteration in his pulse.

Experiment 5.-Three hours after my usual breakfast I took 3 ounces of a strong decoction of the leaves. Pulse 72.

In five minutes, pulse beat 80 strokes; in ten, 84; in fifteen, 80; in twenty, 80; in twenty-five, 76; in thirty, 76; in thirty-five, 78; in forty, 76; in forty-five, 76; in fifty, 76; in fifty-five, 74; in sixty, 74.

In five minutes my pulse increased in force and frequency, which continued until twenty; in twenty-five it was much diminished in fulness; at which time I began to feel sick; my pulse continued small and weak until the expiration of fifty minutes, when it became fuller and began to assume its ordinary stroke.

Began to feel sick (after twenty-five minutes), which lasted a considerable length of time.

Copious purgative effect.

Experiment 6.-Two hours and a half after dinner I gave Mr. J. P. 2 scruples of extract from decoction of leaves. Pulse 74.

In five minutes, pulse beat 74 strokes; in ten, 75; in fifteen, 74; in twenty, 76; in twenty-five, 72; in thirty, 72; in thirty-five, 67; in forty, 67; in forty-five, 67; in fifty, 69; in fifty-five, 70; in sixty, 72.

In fifteen minutes his pulse was much increased in fulness, and continued so until twenty-five; in thirty it became much smaller; in thirty-five it was small and weak; continued weak until fifty minutes had elapsed, when it began to recover its natural stroke.

Fulness of the head, an unusual symptom to him (after thirty-five minutes).

Drowsiness, an unusual symptom to him (after thirty five minutes).

Experiment 7.-At 9.30 A.M. I gave Mr. M. C., a young man in good health, 3 ounces of strong infusion of leaves. Pulse 70.

In five minutes, pulse beat 72 strokes; in ten, 73; in fifteen, 73; in twenty, 75; in twenty-five, 75; in thirty, 76; in thirty-five, 76; in forty, 76; in forty-five, 76; in fifty, 74; in fifty-five, 74; in sixty, 72.

About the twentieth minute his pulse was much fuller, which, however, declined towards the thirty-fifth. It continued small until the expiration of fifty-minutes, when it began to take on its ordinary stroke.

About two hours and a half after my usual dinner, I took 3 ounces of strong decoction of the recent root. Pulse 72.

In five minutes, pulse beat 72 strokes; in ten, 74; in fifteen, 72; in twenty, 66; in twenty-five, 66; in thirty, 65; in thirty-five, 68; in forty, 68; in forty-five, 68; in fifty, 70; in fifty-five, 70; in sixty, 72.

In ten minutes my pulse was much fuller; in twenty it was increased ; in thirty-five it was much smaller, and a little irregular; in fifty it began to assume its natural pulsation.

Operated as a purgative, without inducing any disagreeable sensation

(soon after fifty minutes). Whenever I took the decoction of the bark of the root, or bark of the trunk, in the quantity of 3 ounces, it invariably had a purgative effect, which was very mild.

3 scruples of extract of the pith.

But little alteration of the pulse.

CAUSTICUM.

Authorities. 15, Zeit. Ver. Hom. Erz. Est., vol. i, p. 429, a man, aged forty-six years, drank a swallow; 16, Darto-Massart, Gaz. Med. de Paris, Nov., 1836 (Am. Journ. Med. Sci., vol. xxi, p. 247), Mr. D., aged thirtyfive years, drank some instead of wine; 17, Dr. Jackson, Bost. Med. and Surg. Journ., vol. lxvii, 1862, p. 362, a man, aged seventy-two years, drank some, and at once took a large quantity of sweet oil, after four months he entered the hospital; 18, John W. Ogle, M.D., St. George Hosp. Rep., vol. iii, 1868, Elizabeth G., aged forty-four years, swallowed a quantity of American potash; 19, J. D. Norris, M.D., Maryland Med. Journ., a child, aged four years, swallowed a dessertspoonful of a solution.

Face.-Face pale, presenting the appearance of intense suffering (after a quarter of an hour),16.

Mouth.-Tongue and back part of the mouth threw off a very thick and tough membrane (after two days),.-Mouth and fauces very corroded; on introducing the stomach-pump, small shreds of softened membrane were found clinging to the tube when removed,.-On the following morning the mouth and fauces were in an extremely affected state. Everywhere the epidermal coating of the mucous membrane had been abraded, but still hung partly to it in large pieces, the mucous membrane itself was swollen and loose, the tongue was injected scarlet, the papille swollen, arch of the palate and the uvula extraordinarily swollen, the colors of these parts intensely dark red. In the mouth and fauces the patient had the sensation as if glowing coals were there, together with constant pressure to swallow and hawk up, which increased the pain; he discharged in a large quantity a secretion consisting partly of saliva, partly of mucus. The voice was hoarse and nasal, his disposition bounding on desperation. To these symptoms were added remarkable febrile symptoms (pulse 120) and unquenchable thirst,1.

Throat.-Ejection of mucous membrane of esophagus presenting perfect cylinder of tube,.-Pain along course of esophagus,".-Dysphagia from the first, and had lived mainly on a liquid farinaceous diet (after four months); probangs were used, and there was reported a stricture five and a half inches from the incisor teeth; probang used till some weeks before his death, when he said he could swallow well enough without it,”.

Stomach.-[1540.] Nausea (soon), 16.-Regurgitation,".-Vomited immediately, Severe pains in the epigastric region (soon),".-Great pain in the region of the stomach and the course of the diaphragm,1. Stool.-Black stool followed the perspiration,16.

Fever.-General coldness (after a quarter of an hour),".-Slight perspiration continued for two hours, 16.

CELTIS.

Celtis occidentalis, L.

Natural order, Urticaceæ.

Common name, Hackberry tree, Nettle tree.
Preparation, Tincture of bark.

Authority. 1, J. S. Wright, U. S. Med. Invest., New Series, 9, 1879, p. 339, proving with tincture made from bark; took 4 ounce at 11 A.M. and 2 P.M., symptoms after second dose; 2, ibid., a girl, whose ears were sore and swelled from piercing and wearing cheap rings in them, took 2 ounces in one day.

One hour after, cold and hot creeping all over the body; pulse quick and full; bones ache; flesh sore to pressure on chair-back, cannot sit on hard bench. Stretching of limbs; skin red and puffed; blood vessels puffed; thrilling sensation on the skin all over the body, as if pricked with the points of needles. Sharp pains through the lungs, sticking pain over the right eye. Sleep full of dreams of business; next morning tired and weak, with headache; throat sore,'.-Her face and body swelled. I gave Urtica capitata; the next day the swelling had left the face and body, but her feet and ankles were swollen so that she could not wear shoes,'.

CEPHALANTHUS.

Cephalanthus occidentalis, L.

Natural order, Rubiacere.

Common name, Button-bush.

Authority. E. D. Wright, M.D., Am. Hom. Obs., 1875, p. 177; took ounce tincture on two successive days.

Nervous, excited; felt light and easy, happy (first day).-Toothache (second day).-Raw, sore throat (first day).-Bowels constipated (first day). -Bowels loose, stool offensive; almost affected by the piles (second day). -Griping pains in the lungs (?); in body and limbs, especially in the joints (second day).-Joints of the fingers lame (second day).-Hard dreams about fighting, quarrelling; restless and tossing over (second day).

CHAMOMILLA.

Authorities. 23, Sharp's Essays on Medicine, tenth edition (1874), p. 790, proving of 1st dil. ( drop of sap of the plant); 24, Sharp, Mouth. Hom. Rev., vol. xx, 1876, p. 746, a man took 5 drops mother tincture (half sap and half spirit) at night; 24 a, same, afterwards took 10 drops at night.

Rumbling in the stomach (after half an hour),24 2.-[1450.] Slight indigestion during the day,2-Next morning less free evacuation than usual; and this continued the same for four days afterwards; the color darker than usual,.- Morning evacuations as usual in quantity, but rather darker (second day); no evacuation (third day); evacuation very small in quantity (fourth day),2.-On a healthy person its effect is to produce motions like those of a healthy baby; it increases the secretion of healthy bile,.

CHENOPODIUM ANTHELMINTICUM.

Authorities. 2, P. T. T., Bost. Med. and Surg. Journ., vol. xlv, 1851, p. 373, poisoning of a child; 3, Mr. Wm. Smith, Pharm. Journ., Sec. Ser., vol. iv, 1862, p. 330, a man took about half an ounce; 4, T. R. Brown, M.D., Maryland Med. Journ., November, 1878, p. 20, Mr. X., æt. thirtyone years, took about 1 ounces of wormseed oil, and 30 drops of turpentine, death in five days.

The symptoms were those of a narcotico-acrid poison, affecting the brain, spinal system, and stomach. He was insensible, convulsed, and foaming at the mouth; he, however, recovered under the use of emetics, combined with stimulants and demulcents. All remembrance of having taken the poison was completly wanting on recovery,.-Deep, heavy, stertorous breathing, accompanied by a very peculiar rattle, as if there were a ball rolling loose in the trachea; pulse small, weak, frequent, and feeble; eyes insensible to light, or even external objects; convulsive movements of the right half of the body; extremities cold; any attempt at deglutition threatened instant suffocation,.—Disagreeable eructations; nausea; staggering like a drunken man when walking; deafness to the sound of the voice, but exquisite sensitiveness to the sounds of passing vehicles; he remarked as each vehicle rolled by that it sounded like the roaring of immense cannons right into his ear; also annoying buzzing in ears. His manner in smoking was peculiar. He would scarcely light the cigar before he would lay it down again, and take a fresh one, arguing clearly some perversion in taste. This was kept up until interdicted, and by the afternoon his mantel-piece was strewn with cigars only slightly used. Not the least disposition to engage in conversation. To one of his attendants he showed signs of distinct aphasia. He clearly wanted him to get or do something for him, but could not make himself understood. His friend replied by writing, "Don't understand," at the same time handing him the paper and pencil with which to make known his wish. After holding them in his hand in a pensive state for some minutes, with a sort of flourish, he wrote in a perfectly distinct hand, "The paper mu," waited awhile, and then with a painful expression of the realization of his difficulty, returned the materials and lay down. I then repeated the attempt by asking him what medicine he had bought while away from home. After similar preliminaries as before he only managed to write two letters, "Th." In reply to my question as to how he felt, he responded, "I feel all right." The latter, like the other words, were written in a perfectly distinct manner. During all this time his deafness, as described, was progressive, and became so pronounced as to make it impossible to talk to him. Still there was the same kind of sensitiveness to other sounds. For example, when the tea-bell rang, though he was in the third-story, three flights from where the sound came, he, without notice from members of his family, to their utter astonishment, got up and walked as deliberately as ever into the dining-room. He did not seem to know his accustomed seat, and sat at the wrong place. During the afternoon the aphasia was complete, so that he no longer found it possible to express his ideas to any one, which seemed to amuse him very much, as he laughed heartily. His behavior all this time deserves comment. Whatever he did he would keep repeating it for a considerable time. When I entered the room he rose,

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