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throwing his limbs about, groaning and moaning. Apparently unconscious, and did vot speak, por attempt to do so. These symptoms continued for an hour and a half without intermission. He then became comatose, and so continued till his death,269 — After three hours she was very delirious, talking fast, and throwing about her arms in an excited but feeble way; her pupils were widely dilated and insensible to light; her pulse was 126. Three-quarters of an hour later she was very restless, tossing about the bed, picking at the bedclothes, and throwing about her arms in a meaning.

but partially conscious of what was said to her. A “calabarized disc” was placed in one eye (the left); in about twenty minutes the left pupil had contracted to a pin's point, the right pupil remaining widely dilated and insensible to light; the eyes continued thus till death, which occurred sixteen hours after taking the poison,269. - [2550.] He was quite delirious, the delirium being of a mild vagarious or fantastic character. He could neither hear vor speak plainly, and labored under hallucinations, but was otherwise unconscious. The pupils were widely dilated, and the eyes had a staring look. At first he complained of pain in his throat and of imperfect sight, objects appearing white to him. His pulse was feeble, and almost countless. Urine small in quantity for the first twenty-four hours,16? — The symptoms were similar to those in case one, with the addition of a flushed face, more active delirium, the grasping at imaginary objects and picking of the clothes being also much more marked,26 — Immediately after the second draught he walked out, and noticed at once dimness of vision, dryness of mouth and throat, constriction of fauces, a feeling as if the tongue was enormously swollen, dulness of intellect, and weakness of knees, with want of muscular co-ordination. Having reached his room at 6 P.M., two hours after second dose, he became alarmed at his symptoms, called his landlord to his assistance. The patient was running up and down the room, drinking large draughts of water, upsetting pitchers, and in danger of falling. Medical aid was summoned at once. It was noticed at this time that the tongue was very red, and the secretion of urine increased. There were hallucinations like those of delirium tremens, disagreeable, vanishing instantly, and immediately after their departure the patient was aware of their unreality. The yellow corpse of a tall man, shrouded in white, tried to share the patient's bed with him, and the unwelcome visitor was promptly ejected. A crimson serpent came from the foot of the bed, with the design of fastening upon the patient's neck. Rising to his knees, he with his fist drove the serpent's head deep into the bed, and instantly the apparition vanished. He asked his attendant (for he was practically blind) if the blanket had a red border to account for the hallucination. There were large sea-turtles about the room, such as he had seen in the Pacific. After an hour or two of sleep in the early morning the delusions became agreeable, and continued all day. While riding out in the afternoon with a medical friend, trees became personified to him as people in fantastic costume. In the morning there was severe pain in both renal regions, which he partially relieved by pressure with his fists, the elbows planted in the bed, and the body raised in that way quite off the mattress. Further details are given derived from medical attendants. The delirium was “most busy.” Picking things from the bedclothes, rising in bed to gather things from the pictures and walls, muttering to himself, he had little time to notice those about him. Great mental and physical prostration, sleeplessness, and pain in the left kidney followed the accident,285 — He was very restless and noisy. He was continually getting in and out of bed, and talking loudly and incoherently to imaginary persons, who, as he said, were trying to take away his bedclothes. He complained of faintness, and of soreness and dryness of the throat, and pain across the forehead. He had vomited once and had been several times to the water-closet. He said his sight was all right, but evidently did not know what he was saying. Temperature 98.5°; pulse 140, very weak. The skin was noist; the face flushed. The pupils were widely dilated and quite insensible to light,280,- All but two had delirium of a busy, restless, vivid character, but generally rather pleasing than otherwise. The patients appeared to think that they were pursuing their ordiDary occupations; one boy appeared eager in flying a kite; another pulled tables and chairs about, thinking he was working in a coal pit; while the woman appeared remarkably busy with her ordinary household duties. All their movements were of a quick excited character, strikingly resembling delirium tremens. In none of the cases in which delirium was present were the symptoms alleviated until sleep was obtained; and after sleep, the patients felt comparatively wel1,261. — General excitement. This was followed by giddinese, a feeling of intoxication, and a disposition to quarrel, laugh, and talk. The pulse became accelerated, and the mind filled with hallucinations, which increased to a state of absolute madness. This state lasted from one to twelve hours, and was then succeeded by one of insensibility, somewhat similar to that of a person in the last state of intoxication. In the fatal cases, this state lasted to the end,258 -She began to snatch at objects on the floor and elsewhere, which objects only existed in her own fancy. These visionary phenomena were, by her talk, found to be chiefly articles of work and various insects, beetles, flies, etc. (after five hours). As evening came on, she became nearly blind, restless to an inordinate degree, excessively and loudly talkative, incoherent and unmeaning in her words, which almost wholly, along with the movements of her hands, betokened a concern in her employment, or some immediate interest in her brothers and sisters who were not present. The tongue became somewhat dry, thick frothy mucus adhering to its sides. The skin was still more hot, and the pulse as high as 120. The delirium from this time rapidly increased; at one time expressive of great joy, at another great terror,266 -- What was particularly observable in this case was a great deal of exhilaration or flow of spirits; a marked stimulation of the brain. The child did everything in a hurry, and saw the bright side, rather than the dark one, of what was observed. The Belladonna was taken about 4 P.M. The greatest amount of excitement or stimulation showed itself between 7 and 8 P.m., and it was fully 11 P.m. before she could be quieted so as to fall into a disturbed sleep, **). — Appeared dazed, and was ignorant of what had occurred, like one who had had an epileptic attack (second day),2*8. Seems to see birds flying past and wishes to follow them, —[2560.] She moved her hands as though she wished to seize something, 247 - His speech is disconnected,247-Raye and convulsions, with grinding of the teeth, 248. Laughs in the most extraordinary manner, 247. - Laughing and talking altervately,"1.—Constant loquacious delirium, he talks without cessation of the pains at the neck of the bladder, *. -Taciturnity,247.— Remarkable loquacity,447.—Extreme anguish and agitation,349 —A few minutes after eating the tart he became drowsy, bis lethargy soon increased, his countenance changed color, and the pupils of his eyes became dilated; had a strange coppery taste in mouth; staggered on going upstairs, and fell down insensible. He subsequently became delirious, and was very rough. His con


tortions were dreadful. He attempted to strike his wife in his delirium, and when he recovered a little, said he was sorry, and asked her to kiss him,256 —2570.] Comatose condition, in which she died (one case), 261.

Head.-Confusion of head,200 – Vertigo,242 261. – Vertigo, with malaise, 243, - On getting off the couch she was noticed to be giddy and confused (after five hours),266 - Instability of the body, without vertigo,246 —Heaviness of the head,24? — Pain in head,261,- Violent headache, particularly in the orbital region, accompanied by extreme redness of the eyes and face; the redness gradually extended over the whole body, and after a few minutes the whole skin was as red as in scarlet fever,244.

Eye.-Eyes sunken,242.—[2580.] Eyes haggard and brilliant,249.—Lids widely separated,248 - Pain in eyeballs, which felt as if starting from their sockets, 161 - Pupil. Pupil dilated,268 280 278. — Extreme dilatation of the pupils, with sensitiveness, 1 - Pupils widely dilated while the delirium continued, 261. — Pupils greatly dilated, not contracting in ordinary light, and very moderately contracting in full sunlight (after two hours and a quarter), -Pupils insensible," --One drop of the tincture was added to ninety-nine drops of water, and the right eye was rubbed in the usual way, but no effect was perceived. Afterwards one drop of tincture was added to nine drops of water, and this was applied in the same manner, again no effect was noticed; then a drop was added to four drops of water, and applied; this experiment succeeded, a perceptible contraction of the pupil was noticed. Some months later the last-mentioned experiment was repeated at noon. Two drops of tincture were added to eight of water. Small portions of this dilution were rubbed over the eye at intervals during half an hour. At the end of this time the pupil was slightly contracted, it was less than that of the other eye. Afterwards the remainder was rubbed over the same eye, at intervals during another half hour; a slight dilatation of this pupil was noticed, it was larger than the other. This dilatation afterwards increased considerably, and had not disappeared on the following morning,"11 - Vision. Weakness of vision; it is difficult to distinguish letters, and he is obliged to hold the paper at a greater distance than ordinarily,246-2590.] Indistinctness of vision,261 - Disturbance of vision; all objects seemed bordered with yellow,25:- Disturbance of vision wholly confined to the right pupil, which was widely dilated, not responding in the least to alternate light and shade, while the left was in a perfectly normal condition, and responded readily to light and shade. I continued the remedy for about one week, the right pupil remaining fully dilated during the whole of this time, and for two or three days subsequent to its discontinuance, while the left pupil failed to, at any period of the time, show the characteristic effect of the drug,282 — He had no power to distinguish objects for more than three days, 247. -Amaurosis,27 - Double vision and dilated pupil of the same side as that on which the plaster was. The next day the right pupil was still one-third larger than the left,955

Nose.- Several prolonged fits of sneezing,266.

Face.- Flushing of the countenance, ,258 260 — Redness and swelling of the face and lids,248 — Face deep red,449.—[2600.] Risus sardonicus,248 —Convulsions of the jaws and of the muscles of the face and extremities,248 Spasms of the jaws,248.—Spasmodic constriction of the muscles of the jaws, 450.

Mouth.Tongue covered with a white clammy fur, which he could pull off in strings, 280 - Tongue dry and retracted (after pine hours and a balf),278. — Tongue and throat extremely dry,260 — Tongue pale, dry,246 — The speech, 247 250




tongue sticks to the throat on attenipting to spit,246 — Unpleasant metallic taste in the mouth (after ten or fifteen minutes),258 —[2610.] No taste to food,246 - Moved mouth incessantly, evidently with the idea that he was talking, but the sounds he uttered were inarticulate and altogether upintelligible,280 — Difficulty in speaking, articulation indistinct,246. — Loss of

Throat.-Intense redness and heat in the throat and alimentary canal,251. — Dryness of the throat and great difficulty in swallowing, Dryness and heat in the throat,251. — Very great dryness of the throat and @sophagus,246.- Sensation of burning heat in the throat, 247. —Dryness and heat in the throat and pain,252. —[2620.] Heat of the throat and lips, 448. Very deep-red color of the mucous membrane of the fauces and palate, 342. -Tonsils swollen,?? - Deglutition difficult, with heat in the throat, Swallowing difficult,248 253. - Paralysis of the throat, which impedes deglutition,246 - Unable to swallow (after one hour and a quarter),266.

Stomach.-Loss of appetite, 248 — Loss of appetite, with loss of taste, -Loss of appetite, with a sensation of feebleness, 92-[2630.] Thirsty (after one hour and a quarter),266 - Unquenchable thirst,248 - Nausea, with efforts to vomit, 242 245 --Vomiting, 24-Extreme distension of the stomach and bowels, 242

Urinary Organs.-Extremely painful irritation of the urinary organs, and especially of the neck of the bladder; the patient constantly desired to urinate ; though making every effort the urine passes only guttatim; urine very red and bloody,24.She complained of pain in the region of the bladder, placing her hands on the pubes, and uttering words expressive of desire to pass urine. A catheter was passed amid violent physical opposition and a tremendous torrent of abuse; but only a few drops of urine flowed (after thirteen hours),266 - Excessive desire to urinate, but the urine is bloody and the emission pale, 252.--Excessive desire to micturate, though he could pass only a few drops of perfectly colorless urine,260. -Urine passed guttatim,4.

Respiratory Organs.-[2640.] Hoarseness (after ten or fifteen minutes),234 - The voice naturally hesitating and thick, became during the delirium so sharp and clear that the father would not have recognized it as his child's,6 – Cough resembling croup, 256. — Deep respiration, as in croup,250,- Respiration irregular,248

Pulse.-Pulse 110(after two hours and a quarter); afterwards 120, -Pulse small, rapid,? -Pulse very feeble,318 - Pulse imperceptible (after four hours ),250.

Extremities.-Limbs are violently agitated,242 — [2650.] Weakness of the limbs, 22. —He could not stand till afternoon, and then could only walk with assistance (second day), 978.

Generalities. The wbole body is in perpetual movement,"1.-Convulsive catching of the extremities, face, and trunk, such as animals have when bitten by venomous serpents,260 — In a few minutes she vomited slightly, and in less than an hour after she commenced having spasms, which continued, alternated with periods of repose, until two hours and a half later, when she appeared to be sleeping soundly. Pulse 130; repirations 20 per minute; the entire surface of the body was covered with a very bright scarlatinal eruption, with occasional livid spots of variable size. Upon lifting the eyelids found the pupils dilated to such an extent that only a very small circle of the irides remained visible,281. — The child was in his mother's arms, or partially so, as there did not appear to be a muscle in






his body but what was in spasmodic action, especially those of the extremities. The skin, in color and to a certain extent in thickness, had the appearance of scarlet flanvel; the teeth were tightly clenched, with a little froth flying out between them at each irregular spasm of the muscles of expiration ; eyelids widely separated and fixed; pupils dilated to their utmost extent, and immovable; totally insensible; pulse could not be counted on account of the incessant muscular twitching,?? --Immediately after last dose stupor, swelling around the throat and jaws, great flushing of the face, and dilated pupil. The flushing extended to and even above the roots of the hair on the frontal region. It was difficult to rouse the child; he stared when awakened, and was hard to control. He made wild resistance to anything done for him; if left quiet went off soon into a stupor. The heart was acting violently, beating hard, and more than 144 in the minute. Had illusions ; saw visions on the floor; talked ponsense. Passage of an ounce of dark-colored urine,270.-In five minutes she was drowsy but conscious. The skin was very dry; the pupils widely dilated; face flushed. The skin flushed more readily than natural on irritation. She soon fell asleep, and woke three hours and a half after the poisoning, when she yawned and sneezed frequently. After this she fell into a doze, and woke in a second or two with a cry, and with slight convulsive movements. She tossed about a good deal. In four hours and a half she was very delirious, had unpleasant illusions, and screamed from fright. She followed with her eyes, in a rapid manner, imaginary objects. She tried to talk, but her words were inarticulate. There were slight convulsive twitchings. She did not know her mother, nor could her attention be attracted by objects held before her eyes. The skin was very dry. At about this time a deep, sharply-defined, uniform blush appeared on her face, neck, arms, trunk, and thighs. The delirium continued, but in about eleven hours the delusions appeared to be of a more pleasant character, and she occasionally laughed, and from this time on she continued to improve, 973 — Three presented marked symptoms of poisoning. One showed the following effects: He was a boy four years of age, and he ate the berries about twenty minutes before 3 P.M. At 3 o'clock he was sleepy, and lay down. About ten minutes later he had marked twitching and jerking of the hands and, slightly, of the lower limbs. He would partially awaken, and then instantly fall asleep again. The nervous tremors continued all the time, and rather increased. The above symptoms continued for about an hour and twenty minutes from the time of the poisoning, when an emetic of Sulphate of zinc was administered. This produced a rather copious watery discharge from the stomach, with a few fragments of the Atropa berries. Then an entirely new set of symptoms supervened. The child was wakeful, and made rasses as if picking up things, and would appear to pour them from hand to hand. He would run against things backward, sideways, and forward ; then he would whirl on one foot, and run against things as before. In the midst of these movements he presented an episode, by throwing up his hands and asking a blessing, by then calling for bread, and appearing to think he had it, by taking up his apron and biting a piece off and chewing it. He immediately followed this by talking of his father and mother, who were at a distance. Again, he would throw things at persons around him, catching at anything that was within his reach. The above was the most marked case of poisoning among these children. The others presented far less demonstrations, their delirium being of a much more painful order. The effects had sensibly dininished by the next morning, and had entirely

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