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NOTE.—Most Arum pains are observed to be very transient in any one part, and to course along the extremities, sometimes in one direction, sometimes in the opposite one; they are not very sharp, and are generally intermediate in character, between aching and shooting. Those in the nervous trunks partake more of the shooting character, but always leave an aching sensation behind them. I have not been entirely free from these pains longer than a few minutes at a time, for more than two hours, having noted down only the most prominent. At first they were almost entirely confined to the right side ; now they are limited chiefly to the left. I have just had one of these characteristic pains in the left side of the head; it began in the left occipital region, gradually subsided, and reappeared successively in the left temporal and left frontal regions. This remedy acts primarily and pre-eminently upon the nervous system, and through it upon the circulation.

12.30 A.M. Pulse 74, full, soft, and slightly irregular.

4 P.M. Have an irresistible desire to pass urine, which is diminished in quantity, very highly colored, and has a burning or smarting effect on the urethra.

6 P.M. Great languor and depression of spirits ; dull, heavy aching in the chest ; sinking feeling at the pit of the stomach ; aching along the spine, particularly between the shoulderblades and in the lumbar region; great weakness across the loins; feeling of extreme prostration.

NOTE.—The urine subsequently passed normal both in amount and character. The symptoms last mentioned continued to increase until the exhaustion became so great that I was compelled to retire at the early hour of 8 P.M. At this time there was a slight perspiratiou upon the neck and breast, the first that has appeared during the proving.

July 9th. Awoke at 6 A.M. greatly refreshed. Found myself quite hoarse ; expectorated a small quantity of thick mucus; throat raw and tender ; rattling of mucus in larynx during expiration, but which ceased on rising, except when the expirations were prolonged by voluntary effort. Conjunctiva highly injected ; lids dry, stiff, and slightly agglutinated at their edges, which burn and smart.

NOTE.— The proving was continued through the month, with the development of but few additional symptoms. The bowels were somewhat irregular, at one time slightly constipated, at another somewhat loose, but never any decided diarrhæa. Paroxysms of dyspnea would sometimes occur, with much aching in the chest, and always associated with a considerable secretion of mucus in the larynx and trachea.

On the 10th, and also on the 17th, shooting pains in the right ear, sometimes very severe.

On the 23d au aphthous ulcer appeared on the tongue, and on the folloving day the mouth and throat became so sore that the proving bad to be discontinued. It was resumed, however, on the 25th, by taking one drachm of "matrix;" this produced a violent asthmatic attack at night, and lighter ones on each succeeding night for about a week, when they left me altogether, but I still have (August 1st) an annoying cough, and a mucous rattling in the larynx, which indicate that this will prove to be a valuable remedy in laryngeal, bronchial, and pulmonary complaints.

August 1st. Took one drachm of the "matrix.” Immediate effects similar to those already detailed.

August 3d. Deep shooting pains in the right ear; cough from laryngeal irritation, worse at night and when lying down; constant rawness of the throat, hoarseness, and rattling of mucus in the larynx.

August 4th. Similar symptoms, the shooting pains in the right ear occurring frequently, and continuing sometimes for ten or fifteen minutes.

August 5th. Similar symptoms, the ear pains being still persistent.

August 6th. Symptoms continue as before, with occasional shooting pains also in the left ear.

August 7th, No change in symptoms, except that I have had three copious bilious passages from the bowels, attended with aching in the abdomen and burning in the rectum.

August 8th. Bilious diarrhea, borborygmus, and the escape of much flatus from the bowels.

August 9th. Bowels regular; slight burning in urethra after micturition.

August 12th. No marked change in symptoms until last night; coughed all night; in the morning had a very bad tatse in the mouth; tongue and mouth coated with a foul slimy mucus, having a putrid taste; but the most important symptom was a purulent expectoration, consisting of thick, heavy, yellowish-white pus.

August 16th. Since the 12th instant I have continued to raise this purulent secretion from the larynx in large quantities. Last night I was so annoyed by the gravity and persistence of the laryngeal symptoms-violent cough, hoarseness, rawness of the throat, and profuse purulent expectoration, which greatly alarmed my wife-that I took a dose of Spongia 3d x, which so far relieved me as to secure a good night's rest, the first I have had since the 12th instant.

August 17th. Frequent copious emissions of limpid urine.

August 18th. Inclination to urinate every hour or so during the day; urine increased to four or five times the normal amount; tenderness and slight smarting or burning of the orifice of the urethra, especially during micturition. Eruption of pimples, a species of lichen, on the nose, and a patch of urticaria on the right arm near the elbow.

NOTE.-During the proving, i. e., for the last four or five weeks, I have been entirely free from an intolerable itching of the scrotum-a chronic pruritus—of ten or twelve years' standing. I have also noticed during this time a great diminution, and most of the time an entire absence of, the sexual desire, penis flaccid and relaxed. This condition of the generative organs and a slight laryngeal irritation are the only pathogenetic symptoms remaining at this date (August 220).

ATROPINUM.

Authorities. 30, Dr. Chassaignac (Gaz. des Hop., January, 1853), Am. Journ. of Med. Sci., vol. lii, p. 510, 3 or 4 drops of a solution made with 5 centigrams of Atropine in 30 grams of water, acidulated with acetic acid, were dropped into the eye of a man suffering with cataract ; 31, Dr. Bethune, Bost. Med. and Surg. Journ., vol. Ivi, 1857, p. 201, made three successive applications to the eye, of a solution of 2 grains to the drachm; 32, M. T. Saddler, M.D., Med. Times and Gaz., 1868 (1), p. 391, a child, aged three months, took a teaspoonful of a mixture containing a grain of the sulphate in a fluid drachm, afterwards 6 drops; 33, Geo. Lawson, Lancet, 1868 (1), 570, effects of the application of the sulphate to the eyes of two persons ; 34, S. R. Percy, M.D., Prize Essay, 1868, p. 15, took jo grain of the sulphate in 1 ource water; 35, S. W. Gross, M.D., Am. Journ. of Med. Sci., Oct., 1869, p. 401, Mrs. H., aged forty.three, took 3 grains of Atropia, death ; 36, F. H. Parsons, M.D., Brit. Med. Journ., 1869 (2), p. 675, a man, aged forty-five years, swallowed less than 2 drachms of a solution of the sulphate; 37, A: W. Stocks, Brit. Med. Journ., 1870 (1), 489, for an attack of lumbago, made a hypodermic injection of 6 minims of a solution containing 1 grain alkaloid to 2 drachms water, with relief, afterwards used the same quantity obtained from a different druggist; 38, Drs. Millick and Kerper, Med. and Surg. Reporter, vol. xxvi, 1872, p. 257, a lady, for rheumatic iritis, took a solution containing about 1 grain Atropia, and immediately drank hot coffee; 39, S. Buckley, Pharm. Journ., Third Series, vol. ii, 1872, p. 597, Mr. A. Harris, took some Atropia in food, death ; 40, Roderich Zeiss, Ueber die Werkung des Atropins auf den Puls., Jena, 1875; 41, Dr. Hugo Magnus, Zehender's Klin. Monatsbl., 1876, p. 386, Royal Loud. Oph. Reports, 1877 (Am. Journ. of Med. Sci., New Series, No. 150, p. 569), effects on the eye; 42, T. E. Murrell, M.D., Phila. Med. and Surg. Rep., Sept.

, 1876, p. 269, a man, aged forty years, took a solution of Atropia ; 43, Henry Gibbons, M.D., Pacific Med. and Surg. Journ., 1876, p. 466, a child, aged three years, took an indefinite quantity of a solution ; 44, R. L. Bowles, M.D., Brit. Med. Journ., 1876 (1), p. 533, dropped 4.drops of a solution of 4 grains to 1 ounce, into two persons' eyes ; 45, E. Nettleship, ibid., p. 444, a woman, aged forty-four years, for iritis, applied a solution of the sulphate, 4 grains to 1 ounce, several times a day to the eye; 46, J. Oscroft Tansley, Med. Rec., vol. xii, 1877, p. 334, a young woman, with tinnitus aurium in one ear, was given a solution of the sulphate, 4 grains to 1 ounce, to be instilled into the ear daily; 47, same, a woman applied a plaster to the right side; 48, E. Wilson, Lancet, 1878 (1), 165, a woman, aged forty-three years, and her daughter, aged thirteen years, drank a lotion containing 3 grains of the sulphate ; 49, A. S. Greenway, M.B., Brit. Med. Journ., 1878 (2), p. 516, Chas. S., aged fortyfive years, took over a teaspoonful of Atropia; 50, J. C. Mackenzie, M.D., Cincin. Lancet and Obs., Feb. 1878, p. 148, A. C. H., aged twenty-six years, took 20 grains of the sulphate; 51, F. C. Holts, M.D., Chicago Med. Journ. and Examiner, vol. xxxviii, 1879, p. 43, a man, aged seventy-two years, applied a solution of Atropia to the eye for several days.

In twelve days she returned considerably disturbed in mind, saying she could not see well with the eye upon the same side as the ear in which the Atropia had been used. It was examined and found to be strongly under the action of Atropia, the other eye being normal," - Acute glaucoma ; the Atropia was dropped in to facilitate a proper examination of cataract. The right eye only was affected, though the drops had been put in both. The patient had been seen on two occasions before the Atropia was used, and there was no occasion to suspect any glaucomatous condition. The symptoms came on within a few hours of the drops being used,".-In one case there was acute conjunctivitis, lasting several days ; in the other, erysipelas of the lids, spreading to the face and head, was excited on two occasions, a period of six months intervening,**.-In four or five days she began to have difficulty in seeing with her right eye, being the eye upon the same side of the body to which the plaster had been applied. Upon examination the pupil was seen to be considerably enlarged, and the eye was undoubtedly strongly under the action of belladonna, the left eye being normal,".[520.) Dr. Rothbaupt, aged twenty-five years, whose normal pulse was 60 to 64, at this time 64, injected 0.00025 gram Atropia ; pulse gradually fell in five minutes to 52; during the next twenty minutes it fluctuated between 50 and 60; after twenty-six minutes it was 48; it slowly but gradually rose, until after an hour it regained its normal rate, and after an hour and a quarter continued regular at 60. Another man, aged twenty-five years, with pulse constantly at 68, took 0.0005 gram ; after seven minutes pulse 60; after thirty-three minutes 68 ; thirty-eight minutes 72 ; sixty-two minutes 78; seventy-seven minutes 78, where it remained constant. K. R., aged forty-six years, injected 2 milligram; pulse rose to a maximum of 70 beats. R. Z., aged twenty-five years, with a pulse of 60; rose to a maximum of 68. B., aged twenty-five years, pulse 64; rose to a maximum of 74. 0. Z., aged twenty-one years, pulse 60; rose to a maximum of 80. The same prover, K. R.; the pulse fell after ten to twenty minutes 10 beats. R. Z., the same. B.'s fell 10 beats in one to ten minutes. 0. Z.'s fell 6 beats in ten to twenty minutes. Another series of experiments with 0.00075 gram; pulse 62, fell after twelve minutes to 48; after thirty-nine minutes it was 78; after forty-nine minutes 86 ; after which it gradually returned to the normal. Same man subsequently injected 0.001 gram (or 1 milligram), pulse 60; in seven minutes and threequarters it fell to 52; after thirty minutes it was 102; after which it returned to the normal and did not fall below it. Another proving, with 1} milligram; pulse 68; in twelve minutes 52; in forty minutes 104; after which it gradually returned. After an injection of milligram, the maximum fall of the pulse was reached in twenty-six minutes, and lasted fifty minutes. After į milligram the maximum was reached in sixteen minutes, and lasted forty-one minutes ; after { milligram the maximum fall was reached in thirteen minutes, and lasted twenty-one minutes. After 1 milligram the maximum fall was reached in seven minutes and lasted fourteen minutes. After milligram there was no rise in the pulse. After ! milligram the maximum was reached in eight minutes, and it lasted fourteen minutes. After milligram the maximum rise was reached in twentysix minutes, and lasted one hundred and nineteen minutes. After 1 milligram the maximum rise was reached in forty-two minutes, and lasted one hundred and sixty-four minutes,"—In half an hour vertigo occurred, with wanderings of vision. In three-quarters of an hour all the symptoms of poisoning with Belladonna were present, flushed face, enormously dilated pupils, and incessant hallucinations. The patient drew his coverings over him, and attempted to seize objects that he saw in the air. On attempting to rise his legs failed under him, and he could not take two steps without being assisted. His pulse was 120 and full. In the evening he became more calm, but the bladder was distended, and he was unable to empty it, so that the catheter had to be used. He lost all recollection of his illness except his delirium and its accompaniments,3o.--Delirium, uncertainty in his gait, with absence of sleep and difficulty of swallowing. On the day after but one, he had another attack of delirium, somewhat resembling delirium tremens, seeing imaginary persons in the room,5" — It had a distinct persistently bitter taste, and produced a numb sensation upon the tongue, somewhat similar, though less in degree, to that produced by aconite. In about ten minutes it produced a sense of nausea, which continued to increase until an effort was made to vomit. Although the effort at vomiting was made several times, nothing was thrown up. To this intense thirst succeeded, and a frontal headache, which was lessened by closing the eyes. Next a dryness was felt in the throat, and the tongue and mouth felt dry and feverish. These symptoms were not relieved, and only mitigated for a short time, by drinking water. This dryness of the throat increased, and was persistent for several bours, causing at first almost constant deglutition, and towards the last a strong effort to avoid deglutition, which had become painful. During the first two hours the pulse was less frequent, but afterwards became smaller and more rapid. The eyes soon lost all control of distance; a printed book held at the usual distance was a perfect blur; held at a long distance, letters could be distinguished, but the words upon looking at them, soon ran into confusion. Objects at a distance could be plainly seen, even a little more plainly than natural (hypertrophia), but near objects, though for a moment distinguished, soon lost their distinctness. A numb or crawling sensation, a formication, was felt down the back, upon the arms, and back of the hands. This formication was intense and very unpleasant upon the palate. Light became unpleasant to the eyes, causing pain deep in the eyeballs. Motion became unpleasant, and if the feet were lifted in walking, the floor seemed to recede from them before they again were put down. A sliding of the feet along the floor seemed to be the only safe way of locomotion. The head began to be dizzy, and for fear of falling it was necessary to be seated in the easy chair. Thirst at this time was very great, but only little water could be taken at a time, as the effort of swallowing was unpleasant. A languid feeling came on, as the semirecumbent position was assumed, and whether sleep, accompanied with wild dreams, or waking hallucinations followed, it was impossible to tell. Whether the brain was troubled with hallucinations, or with wild fantastic dreams, they were exactly the opposite of those produced by Cannabis indica, for all the imaginations and conversations were of the long past, none of the future. Whether there was total blindness, or merely an imagination of blindness, could not be remembered; but, if there was blindness to the external eye, the mind saw all its images with great distinctness, and the impress of them was left with vividness. There was consciousness of individuality, but the actious we performed by others, who were embodied spirits of those long since departed. Lengthy conversations of a most pleasant character were held with Plato, Alcibiades, Aspasia, and others. How long this state lasted cannot be told; but sound, profound sleep must have followed, for consciousness to external objects did not return till sixteen hours after taking the Atropia. Awaking took place suddenly; there was no pain, no headache, nothing abnormal but a languor and disturbed vision. The bladder had not been emptied during these sixteen hours, and although a large quantity of water had been drunk, but a moderate quantity of urine was

VOL. X.-24

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