and was particularly severe on rising up; after a few days, it continued so violent that I took a dose of Sulphur (sixth day),'.-Pain in the small of the back, especially troublesome when walking or going upstairs and on rising from a seat,.-Violent pain in the small of the back,".

Extremities.--Increased stiffness of the limbs, at night,.-Pain in the middle of the right tibia, confined to a small spot (third day),'. Generalities.-[40.] Weakness,5 6.

Skin.-Itching on the forehead and beard (second day),'. Sleep.-Restless sleep,25.-Numerous dreams (fourth day),'.-Dreams at night,.

Fever.-Cold feet (sixth day),'.-Morning sweat,".-Perspiration at night,.-Profuse perspiration at night,. Sweat.-(Night), Stiffness

Conditions.-Aggravation.-(Morning),

of limbs; sweat.-(Cold drinks), Toothache.-(After drinking), Eructations.-(Going upstairs), Pain in small of back.-(Pressure), Pain about pylorus. (Standing), Pain in small of back.-(Stooping), Pain in small of back.-(Rising from sitting), Pain in small of back.—(Walking), Pain in small of back.

UPAS.

Strychnos tieuté.

Natural order, Apocynaceæ.

Common name, Ipo of Borneo (not of Massachar, which is Upas antiar).† Authorities. 1, Dr. Pitet, Journ. de la Soc. Gall., 1st ser., vol. iv, p. 65, took drop doses in water, beginning with 15th dil., left off (fifteenth day), began taking 3d and 2d dils. (twenty-fourth day), 1st dil. (twenty-sixth day), drank in twenty or thirty swallows half a liter of water, to which had been added 5 drops diluted tincture (twenty-eighth day), mixed 10 drops tincture with same quantity of water (twenty-ninth day), 20 drops tincture in same quantity of water and in portions at half-hour intervals (thirtieth day), handled the Upas tieuté in preparing 30th dil. and some symptoms reappeared (fifty-eighth day); 2, same, Mad. M. Th. P., æt. twenty years, took 15th dil.; 2a, same, took 1st dil.; 2b, same, took 20 drops tincture in half a liter of water; 3, Dr. Mannkopff, Wien Med. Woch., 1862 (A. H. Z. M. B.), a man took 3 grains; 4, Morris Wiener, M.D., from MS., took 2 drops 3x in a teaspoonful of water (first day), 3 drops 6x in water at 7 A.M. (third day); 5, same, took 1 drop 3x in water at 6 A.M. (first day), 20 globules moistened with 3x (third and fifth days), 40 pellets (sixth day), 6 drops 12x in morning and at 11 P.M. (seventh day); 6, same, took 1 drop 3x at 10 P.M. (first day), 5 drops (second day).

Mind. Very lively mood,.-Depressed spirits; aversion to speaking (seventh day),.-Great moral sensibility (fourteenth day),'.-Melancholic; has to force the tears back; cold towards his friends, repelling every one (sixth day),.-Morose (second day),.-Morose and irritable (first day),. -Morose without cause; easily exasperated; likes to quarrel (third day),. -Morose and does not want to speak (fifth day),".-Cross, irritable, after

"Upas antiar" is Antiaris toxicaria, of Java, a tree concerning which the most wonderful stories have been told. The accounts of Forsch, translated from the Dutch and published in the London Magazine, 1784, have been freely copied, but are utterly untrue. An arrow poison of Java, the "Siren-boom," is prepared from the bark of this tree, which is very poisonous; we have, however, no reliable accounts of its actions on men.

going to bed (second night),.-[10.] Irritability, sensitiveness (thirtysecond day),'.-Irritability, irascibility (twenty-ninth day),'.-Thinking is laborious and difficult; transient cloudiness of the mind (thirtieth day),'.—— Extreme difficulty in fixing the attention (thirty-fifth day),'.-Sensible weakening of the memory several days past (fortieth day),'.-Very marked diminution in readiness of thought; inability to concentrate the attention, to express himself, to apply technical expressions, to recollect; irritability; very marked diminution of muscular strength; these symptoms continue, becoming more and more marked for several days (forty-first day),'.

Head.-Vertigo. Head muddled (as if proving Cocculus), (sixth day),.-Vertigo, as if falling; this lasts only a few seconds, and terminates with a pressing headache in the forehead (third day),.-General Head. Dull pains in the brain (forty-third day),'.-Headache all over the head after going to bed (second night),-[20.] Pressive heaviness throughout the head; great tendency to feel cold (thirty-sixth day),'.-Some twitchings in the brain and the orbits (thirty-second day),'.-Severe pulsating pain all over the head, on waking in the morning, disappearing in the open air (third day),.-Forehead. Slight frontal headache,.-Pain in the forehead (after second dose, seventh day),.-Constant dull tearing pains in the forepart of the brain, on the right side (in the afternoon), worse when walking (afternoon and all the evening), (twentieth day),'.-From time to time, during the day, dull and prolonged shootings in the right anterior lobe of the brain (twenty-ninth day),'.-Dull pain or shootings, sometimes dull, sometimes sharp, in the anterior portion of the brain, chiefly on the right side, etc., ut supra (thirtieth day),'.-Dull deepseated pains in the base of the right frontal lobe, above the orbit (thirty-fourth day),.-Sharp contusive pains in a line with the left frontal eminence, aggravated by movement, walking, and especially by going upstairs, to such a degree that it seems as if the brain were rudely shaken, from morning to midday (forty-first day); on the following day these symptoms diminish,'.-[30.] Boring shootings, very sharp and deepseated, in the left side of the forehead, near the temporal fossa (thirty-fifth day),'.-Boring pain, which is felt simultaneously in the frontal eminence and in the occipital protuberance of the left side (twenty-sixth day),'.-Frequent dull shootings in the frontal lobe on the right side (twenty-eighth day),'.-Some dull twitchings in the anterior left side of the brain, above the orbit (eighth day),'.—Some twitchings in the anterior lobes of the brain (twenty-ninth day),'.—Pulsating headache in the forehead and through the left eye, with pressure, as if the eye were pressed inward, in the evening, after going to bed (second day),".Temples. Every few moments pressure in both temples, especially the left (fifth and sixth days),'.-Sharp pressure in the left temple (in the evening), (forty-first day),'.-Superficial drawing pain, which, every few moments, traverses the left temple from before back wards, and ceases at the outer angle of the orbit; the part is hot and painful to touch; this pain was felt all day yesterday, and this morning subsided into a dull pain (fifth and sixth days),'. -Vertex and Parietals. Pressure on the vertex (first and second days),.-[40.] Pressure, painful heaviness in the top of the head (thirty-fifth day),'.-Dull pains in the right side of the brain, sometimes in front, sometimes behind, or inside the orbit, near the root of the nose, with feeling of internal heat, uneasiness in the whole head, and sometimes sharp lancinations in the brain and the orbits (forty-fourth day),'.-Several shootings deep in the brain on the right side (seventh day),'.-In the forenoon, boring shootings in the parietal region of the right side of the brain (twenty-fourth

day),'-Some dull shootings in the right side of the brain (thirty-second day),'-Frequent shootings in the right side of the brain (fortieth day),'.Some pains in the right side of the brain (forty-first day),'.-Violent shootings in the right side of the head,".-Frequent shootings in the brain, chiefly on the right side (thirty-seventh day),".-Occiput. In the afternoon painful heaviness in the occiput, accompanied with throbbing isochronous with the arterial pulse (as after sexual excess), (twenty-fifth day),'.— [50.] Dull pressure, pressive weight in the posterior part of the cerebrum and cerebellum (thirty-fifth day),'.-Headache in the occiput, a pressinginward pain, for more than a fortnight (after two days),.-External Head. Scalp numb, as if going to sleep (first day),".

Eye.-Eyes sunken, with bluish rings around them (seventh day),.— Dull pains in the right eye, in the evening, for several hours in succession (twenty-fifth day),'.-Painful pressure and sensation as of a foreign body in the left eye, when opening and shutting it,'.-In the morning, when waking, sensation of pressure and of dryness in the eyes, preventing the lids from opening, as if there was sand in them (symptom previously experienced after a dose of this medicine), (fourth day),'.-When opening the eyes, sharp and burning pain, like that caused by the presence of a foreign body (fifth and sixth days),'.-Sharp pain, composed of burning, together with a feeling as if from a foreign body, especially in the left eye, and chiefly when opening and shutting the lids (fifth and sixth days),'.The eyes are weak, as after sexual excesses (twenty-fifth day),'.--[60.] Every morning weakness of the eyes, with lachrymation, the lids being so heavy that they close involuntarily, as if from irresistible drowsiness,; (twentyeighth day),'.—Same symptoms of the eyes as on the preceding days; they are very weak; the outer canthus of the left eye is the seat of very acute itching (twenty-ninth day),'.-Every morning weak eyes; itching smarting in the canthi, feeling as of a foreign body, etc. (thirty-fifth day),'.-The condition of the eyes is aggravated; in the morning they are weak and close involuntarily; constant feeling as of a foreign body under the lids; on the inner surface of the right lower lid, near the margin, a small white miliary pustule, hard, and surrounded with a violet circle; redness of the palpebral conjunctiva; itching smarting in the outer canthi; all day, sensation as if there were sand in the eyes (thirty-sixth day),'.-The symptoms of the eyes continue, accompanied with heaviness of the head, heat in the head and in the eyelids, which are red and congested; I inhaled a dilution of Bryonia, and the symptoms of blepharo-conjunctivitis were sensibly alleviated at the approach of evening (thirty-eighth day),'.-The sensation of sand in the eyes returns, accompanied with itching and congestion of the lids, and smarting itching and ulcerated feeling in the outer canthi (fortythird day),'.-All the symptoms of the eyes instantly reappeared; sensation of distress, of pressure, as from sand under the lids; vivid redness of the conjunctiva, the margin, and the angles of the lids, etc., all day long, and especially in the morning (fifty-eighth day),'.-Orbit. Dull pain in the left orbit when opening or shutting the eyes (fifth and sixth days),'.-Dull pain in the floor of the right orbit, in the morning (fourteenth day),'.— Dull pain above the nasal bone, at the internal portion of the orbit, sometimes on the right side, sometimes on the left (forty-fifth day),'.-[70.] In the morning, dull and prolonged shooting in the outer angle of the orbit, even into the nasal bone, on the right side (twenty-ninth day),'.—Dull shootings in the right orbit and in the frontal lobe of the same side (thirtyeighth day),.-Frequent dull shootings in the right orbit, sometimes on

the left side (in the evening), as on the preceding days (fortieth day),'.Shootings in the left orbit,.-Violent lancinations in the anterior and internal portion of the orbit, in the morning, sometimes before getting up (forty-third day),'.-Violent lancinations in the right orbit before getting up (forty-third day),'.-Prolonged and violent lancinations under the orbit, on the right side (forty-fifth day),'.-In the morning, before getting up, severe dull lancinations in the internal portion of the right orbit, on the bone at the root of the nose (forty-fifth to fiftieth day),'.-Lids. Flow of blood from the eyelids (twenty-seventh day),'.--Same condition of the eyes; the small pustule on the right lower lid increases in size, becomes hard, and resembles a cyst (thirty-seventh day),".-[80.] Stye on the left upper eyelid; itching of the outer canthus, with ulcerated feeling (as on the preceding days), (thirty-first day),'.-Redness and heat in the eyelids, chiefly in the left (fifth and sixth days),'.-In the morning, and in the afterpart of the day, redness and itching in the eyelids, chiefly in their margins (twentyfifth day),'.-Acute itching and congestion of the eyelids, chiefly in the morning (twenty-eighth day),'.-Itching in the border of the outer surface of the lower lids (fifth and sixth days),.-Intense smarting itching in the outer canthi, in the evening; it seems as if they were ulcerated,; (thirtieth day),'.-Amelioration of the eye symptoms; there only remains a sharp itching of the lids (fortieth day),'.-Lachrymation. Weeping of the left eye (second day); weeping of the eyes lasted more than a fortnight,.Conjunctiva. Considerable amelioration of the blepharo-conjunctivitis (thirty-ninth day),'.—Ball. Dull shootings in the left eyeball, in the evening (twelfth and thirteenth days),'.-Pupil. [90.] Pupils contracted,3.Vision. Dimness of sight; letters running together; fog before the eyes (second day); the dimness lasted more than a fortnight,.-In the open air dimness, and as if endless strings of white and transparent globules were floating in the air (third day),.-After rising from a stooping position, blackness before the eyes, as if all the blood were rushing to the head, with vanishing of thoughts (third day),3.

Ear. At intervals, dull tearings in the inmost part of the cartilage of the concha of the left ear (thirty-sixth day),'.-Twitchings in the cartilages of the left ear, near the orifice of the external meatus (fortieth day),'.Boring sensation in the right external auditory passage, often repeated (a symptom frequently felt during the proving), (fiftieth day),'.-Burning on right outer ear (second day),".-Both ears stopped, without affecting the hearing (third day),.

Nose.-Violent sneezings and coryza,.-[100.] Coryza (third day),.— Violent fluent coryza towards and during the evening, until falling asleep (second day); a fluent coryza in the forepart of the day lasted longer than a fortnight,".-First, the right nostril, and shortly after, the left stopped up; this changes every few minutes and prevents sleep, in the evening after going to bed (second day),.-Left nostril stopped up and discharging greenish mucus (as in Pulsatilla), (fifth day),3.—Smell as if smelling mauure (fifth day),.

Face.-Yellow complexion (seventh day),.

Mouth.-Tongue coated white (seventh day),.-Tongue coated white; this coating so thick that it can be scraped off (first day),.-After swallowing the medicine, dryness of tongue and throat (first day),.—Burning on the tongue (immediately),.—[110.] Unable to open his mouth to speak (after one hour),.-Blisters on the inner side of under lip, towards the left (fifth day),.—Slight burning in the buccal cavity (first day),'.-Frequent

itching of the palate (twenty-eighth day),'.-Much saliva, which tastes Sour (seventh day),.-Sour taste (immediately after second dose, seventh day),.-Bitter taste on the root of the tongue (seventh day),.-Taste like old coryza (third day),5.

Throat.-(A habitual hawking of grayish mucus, in the morning, which lasted since more than a year, did not appear this morning (sixth day), and not afterwards),.-Pains and acidity in the left side of the throat when swallowing (thirty-sixth day),'.-[120.] The sensation of acidity in the throat extends to the left ear, and the pulse is more frequent than usual (thirty-sixth day),'.-Scraping in the throat causing cough, which produces a sore pain in the thorax, in the morning; at 9 P.M. every symptom of a severe inflammation of the throat appears; burning and soreness in the throat, cough, with severe burning pain, as if the throat would burst, with difficult expectoration of bronchial mucus (second day); every symp tom aggravated (third day),.-Pain, as from a splinter, in the left side of the throat, making deglutition painful, as if the food were prevented from passing into the stomach by a foreign body lodged in the esophagus; the swallowing of fluids becomes difficult; pressing the left side of the throat causes a feeling of suffocation (third day),5.-While writing, a sensation as if the right tonsil were swollen, which is not the case, and severe palpitation (seventh day),5.-The symptoms of the throat are equally persistent (thirty-seventh day),2.

Stomach. No appetite (second day),'; (sixth day),.-Total loss of appetite; aversion to all food, especially meat and eggs, the mere thought of which produces nausea (seventh day),.-Aversion to meat; hunger, but no desire for food after swallowing the first morsel (second day),.-Urgent thirst, bitter risings, and after a meal, risings tasting of the ingesta, all day,.-Violent eructations of wind (after half an hour),.-[130.] Qualmishness, and a feeling as if going to faint (third day),.-A peculiar sensation of heaviness in the stomach,.-In the morning, while hiccoughing, pinching in a line with the lumbar vertebræ (twentieth day),'.

Abdomen.-Pressing pain in the region of the liver (first day),.— Pressing pain in the liver (seventh day),.-Outward pressure in the left hypochondrium (seventh day),.-Stitches in the region of the liver and right kidney, in the evening (second day),.-Shortly after rising, on going outdoors, ulcerative pain in the left side of the umbilicus (twenty-ninth day),'-Much flatulency, wind pressing against both hypochondria, and in breaking, giving no relief; flatus odorless (third day),.—Rumbling in the bowels (seventh day),.-[140.] Smart pinching in the left side of the abdomen, a little below the line of the umbilicus (after repeated doses), (ninth day),-Sharp pains in the left iliac fossa, aggravated by drawing breath, and by touch,2.

Rectum and Anus.-Sharp colic in the rectum, relieved by emission of fetid flatus; shortly afterward, a soft stool, preceded by renewed colic (forty-third day),'.-Lancinations or slow pinchings, which appear to affect the cellular tissue exterior to the rectum on the right side, for several days in succession (forty-third day),'.

Stool. During several days, two soft diarrhoeic stools every day, and on the third day, great prostration (after several doses),".-Two soft stools every day,2.-Soft stools the first days (tenth day),'.-Soft stool preceded and accompanied by colic (thirty-first day),'.-Mushy stool (second day),". -Stool mushy and easy (third day),.-[150.] An hour after the accustomed stool, a smaller one, mushy, reddish, terminating in a discharge of brownish