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to the axilla, the absorbents being very painful. The skin was red, brawny, and covered with patches of an eczematous character,47.-Inflammation of the band, which acquired a scarlatinous redness, and erysipelas followed, 5.

-A gentleman, æt. fifty-two years, dressed his sprained knee with fomentations of tincture of Arnica and water. After two days' use the knee became red, the redness extending down the leg nearly to the ankle, and upon this surface there was developed in a few days a general eruption of papules. A similar process, but of less severity, ensued a day or two later upon the inner surface of the corresponding part of the other leg. The efflorescence upon the legs did not pass into the vesicular stage generally, but remained at its height for a week, and then very gradually subsided under treatment. Three days after the use of the fomentations, an inflammation of the skin of the face began, which increased in severity until I saw him, a week after the injury. His whole face was then very much swollen, of a deep red color, and covered with papules and vesicles towards its periphery, whilst upon the central portions was a very free exudation of serum from many excoriated points, which in parts had stiffened into crusts. The vesicles and papules of the forehead were arranged in prominent and isolated clusters of two or three individuals each. The subjective symptoms were mainly intense itching, with slight burning, and considerable suffering was thereby occasioned for several days,":–Erysipelas in the course of twelve hours. A band of inflammation about three inches in width, and nearly encircling the ankle-joint; color dusky purple, the upper part raised into large flattened blebs, the lower part slightly suppurated, the foot and leg somewhat ædematous; the swelling extended several inches; the whole most exquisitely tender, and appearing like a severe scald or burn more than anything else; the general disturbance was very slight, except from want of sleep; one eye was slightly inflamed, and the eyelids were swollen ; a small patch of erysipelas on the palm of the right hand,56 —Two days afterward enormous swelling of the knee and of the thigh. Two days later diminution of the swelling, but appearance on the knee of an eczematous eruption, with crowded lenticular bullæ, which lasted three weeks. The compresses having naturally touched the right knee, there was eczema here also, less severe but quite as lasting; it was also upon the fingers of the hand which had touched the Arvica. The eruption was very painfu1,57.- Violent twitchings, extreme anxiety, a feeling of constriction at the level of the attachments of the diaphragm, paleness, cold sweat, pulse small and frequent, convulsive movement in the limbs, alternating with trembling of the whole body,". - [930.) Aftertwenty minutes he had a violent headache, vertigo, nausea, and vomiting; these lasted an hour, followed by drowsiness and deep sleep,... -Obstinate vomiting, vertigo, convulsions, 55 — Violent vomiting, intense headache, choleraic diarrhea, epigastric pains and colics, general weakness, shivering of the extremities, pulse very slow and small, . - In five minutes his pulse fell from 70 to 64; at first irregular, it soon became thready and evaded the finger. He experienced an unendurable præcordial anguish; it seemed to him that his heart stopped, and was going to cease to beat; in fact on applying the hand to the præcordial region, one perceived the feebleness and intermission of the cardiac contractions. His face grew pale and almost immediately a great muscular weakness followed; his knees failed him and he felt a desire to sit down, which he could resist only by a strong effort of the will. There were fibrillar contractions of isolated muscular fasciculæ, especially manifest in the region of the jaws, and a sort of constriction of

the temples. We follow with the fingers the spinous processes of all the dorsal vertebræ. The pressure does not give rise to any phenomenon, but as the finger descends and presses on the dorsal vertebræ a lively and sudden sensation of illness is felt, and some involuntary jerks in the muscles of the pape of the neck and of the back; the bead is thrown backward, the trunk is upright. At the level of the last dorsal vertebra the sensation of illness provoked by the pressure is so great that the patient shrinks from our observation. This rather strange localization of the pain, on the level with the last dorsal vertebra, seems to us remarkalıle; we will attentively study the phenomena which accompany it. Pressure develops pain in the waist at this point only, these pains radiate to the epigastrium ; the patient complains of suffocation, and of a sensation like a weight on the chest. These rather alarming symptoms did not last more than twenty minutes. After half an hour there was only great weakness, depression, paleness, a sensation of emptiness in the head, a slight trembling of the hands, some nausea, then great sleepiness. This condition lasted until evening. At 10 P.M. the pulse was still feeble and irregular, temperature 36,6 °C. ; the night was pretty good. The illness terminated the next day by some loose stools, with tenesmus,


Authorities. (227 to 230, from Berridge's Collection, in appendix Brit. Journ. of Hom.); 227, Thos. Garnett, Med. and Phys. Journ., 1801, 542, fatal poisoning of a man by pills of Ars., butter, and flour; 228, Dr. S. Barnum, Med. Repos., 1802, p. 43, a woman took a solution ; 229, Dr. Yelloby, Edinb. Med. and Surg. Journ., 1809, p. 389, a boy, æt. sixteen years, took a pennyweight; 230, W. J. Crowfoot, Med. and Phys. Journ., 1815, 441, children ate it in food ; 231 to 235, John Marshall, Remarks on Arsenic, London, 1817, effects on five persons of eating dumplings containing oxide of arsenic, 233 being a woman seven months' pregnant ; (236 to 241, from Berridge); 236, J. Hume, Med. and Phys. Journ., 1821, p. 466, Mrs. —, æt. twenty, took arsenic; 237, Astley Cooper, Lancet, 1823–24, 156, application to the eye for fungus; 238 to 241, Alexander Murray, Edinb. Med. and Surg. Journ., vol. xviii, p. 167, poisoning of a family ; 242 to 244, Robert Christison, M.D., Trans. Medico.-Chirurg. Soc., 1825, fatal cases ; (245 to 248, from Berridge); 245, Robert Christison, Edinb. Med. and Surg. Journ., 1827, p. 411; 246, John Elliotson, Med.Chir. Rev., 1828, p. 265, a woman, æt. about sixty years, took arsenic ; 247, Christison, Edinb. Med. and Surg. Journ., 1830, p. 67, six persons took it in champagne; 248, Journ. Univ. et Hebd. (Med. Chir. Rev., 1832, p. 162), several persons took it in food ; 249, T. Bost. Med. and Surg. Journ., vol. xii, 1835, p. 334, fatal poisoning of T. D—, æt. twenty-three years; (250 and 251, from Berridge); 250. Lancet, 1835-6 (1), 436, a girl, at. twentytwo years, swallowed 1 oz. ; 251, Journ. de Pharm. (Lancet, 1837–8 (2), 625), several families drank water impregnated with Arsenic ; 252, B. E. Cotting, Bost. Med. and Surg. Journ., vol. xviii, 1838, p. 78, a man, æt. twenty-two years, took about 2 ozs., in wine and water ; (253 to 292, from Berridge); 253, Londonderry Standard (Dublin Med. Press, 1840, p. 371), poisoning; 254, Theophilus Thompson, Lancet, 1843–4 (1), 98; 255, Dr. W. Woodcock, ibid., 1845 (1), 610, Mrs. W., took 1) teaspoonful; 256, J. M. Adams, North. Journ. of Med., 1845, p. 262, J. P., æt. forty-two

years, took 2 drachms; 257, Historical Register (Lond.), (Dublin Med. Press, 1845, vol. xiii, p. 61), a man made arsenical candles; 258, Allison, Lancet, 1845 (1), p. 413, a girl, æt. thirteen years, took a large teaspoonful before 4 P.m., and another dose before 5; 259, Linoli, abridged from Ann. Univ. de Med. (Med. Times, 1846), two men and three children had same symptoms from Arsenic in food; 260, J. Hakes, Edinb. Med. and Surg. Journ., vol. Ixvi, 1846, p. 43, a family drank water containing Arsenic, several cases fatal; 261, Dr. Letheby, Lancet, 1847 (1), p. 44, a girl, æt. nineteen years, took at night 2 oz. fly-water, containing 2} ozs. white Arsenic, death in thirty-six hours ; 262, Dr. L. Owen Fox, Lancet, 1848 (2), 503, fatal poisoning of a man, æt. twenty one years, by a teaspoonful; 263, Wm. Robert Cornish, ibid., 1819, p. 35, a man took 1 oz.; 264, same, a girl took 1 oz. ; 265, Dr. Michael McGee, ibid., p. 311, a girl, æt. ten years, took 10 grs, or more ; (266 to 285, from Dublin Quart. Journ. Med. Sci., 1851, and Dublin Med. Press, 1850); 266, a man and woman, each took 24 grs.; 267, M. G., æt. fifty-six years, took 1} oz., fatal in twelve hours; 268, Miss D., æt. eighteen years, took Arsenious acid ; 269, J. G., æt. thirtythree years, took Arsen. acid in tea, and on the fourth day took 2 teaspoonfuls in coffee and milk; 270, a man, æt. between twenty-five and thirty years, took Arsenic in food ; 271, five persons ate a cake in which a teaspoonful had been put; 272, a woman, æt. twenty-five years, took some in water; 273, poisoning of five persons ; 274, poisoning of seven persons ; 275, two persons took it in food; 276 to 278, a family poisoned by Arsenic in food ; 279, fatal poisoning of M. J. B.; 280, a boy, æt. two years, took a spoonful of rat-powder (Arsenic and flour); 281, a girl, æt. four years, took the same ; 282, M. B., æt. thirty years, took nearly a spoonful in gruel and porter; 283, a man and woman took it in punch; 284, four persons took it in food ; 285, five persons took it in soup; 286, Dr. G. E. Sanger, Guy's Hosp. Rep., 1851, 183, poisoning of a man, æt. nineteen years; 287, Chambers's Edinb. Journ. (Dublin Med. Press, vol. xxvii, 1852, p. 63), effects of leaving off Arsenic-eating; 288, Dr. T. R. Mitchell, Med. Times and Gaz., 1853, p. 612, a man rubbed the liniment into axillæ, pubes, and scrotum ; 289, Dr. T. Brown, Assoc. Med. Journ., 1853, p. 878, a woman, æt. twenty-four years, took Arsenic to procure abortion ; 290, M. Dandin, Annal. d'Hyg. 1854, case of poisoning; 291, Tschudi's report, Journ. de Chim. Med., 1854 (Bost. Med. and Surg. Journ., 1855, vol. li, p. 189), effects of suspension of Arsenic-eating ; 291 a, same, a man took an overdose ; 292, Dr. Wilks, Guy's Hosp. Rep., 1855, p. 364, a man, æt. fifty years, took probably three teaspoonfuls; 293, Samuel C. Pointer, M.D., Med. and Surg. Reporter, vol. ix, 1856, p. 210, Agnes Corbet, æt. twenty-one years, swallowed a teaspoonful, death in twelve hours ; (294 to 296, from Kesteven, Brit. Med. Journ., 1856); 294, Dr. Jago, effects on workmen ; 295, Mr. Pointer, poisoning; 296, Kesteven, effects of leaving off Arsenic-eating; 297, Dr. Halley, Pharm. Journ., vol. xvii, 1857, p. 428, Arsenic in paperhangings ; (298 to 319, from Berridge); 298, Dr. Walter Watson, Lancet, 1857 (2), 281, effects on shepherds of washing sheep with Arsenic; 299, Dr. Robert Crawford, ibid., p. 127 and 181, effects of same; 300, Dr. W. G. Meacham, N. Y. Journ. of Med., vol. iv, 1858, p. 430, poisoning of a man, æt. twenty-five years; 301, Jas. Whitehead, Brit. Med. Journ., 1858, p. 804, a young man poisoned by arsenical wall paper; 302, Mr. H. G. Trend, ibid., p. 725, a woman took Arsenic twice a day, for three months, altogether two tablespoonfuls, to procure abortion ; 303, Jas. Begbie, Edinb. Med. Journ., 1858, vol. iii, p. 961, observations of Valleix and other French writers ; 304, Begbie, ibid., effects in a case of chorea ; 305, Dr. Gibbs, Lancet, 1858 (1), p. 613, a lady took it many years for an éruption ; 306, Dr. Wm. N. Brown, Edinb. Med. Journ., 1858, vol. iii, p. 148, a man washed sheep with a solution of white Arsenic; 307 to 312, Dr. Robert Paterson, ibid., p. 391, different cases of poisoning; 313, Schefler in Gesundheit der Bergleute, effects on cobalt miners ; 314 and 315, Dr. A. S. Taylor, Ophth. Hosp. Rep., 1859 (1), 270, effects of arsenical wallpaper; 316, Dublin Med. Press, 1859, vol. xli, p. 280, shepherds were poisoned by washing sheep with an arsenical wash; 317, Harles, Med. Circular, vol. xiv, 1859, experiments on healthy men with gr. of Arsenious acid; 318, Gonffia's experiments on himself, ibid. ; 319, Manchester Guardian, Pharm. Journ., vol. xxiv, 1859, p. 482, three children were poisoned by arsenical wall-paper; 320, Dr. Lorenz, quoted by Heisch, ibid., p. 556, Arsenic-eaters of Styria ; 321, same, effects on a gentleman ; 322, J. B. Metcalfe, ibid., vol. xx, p. 343, poisoning of Clarence King, æt. three years and a half; (323 to 329, from Berridge); 323, Dr. R. Biggs, Lancet, 1860 (1), p. 8, poisoning by paper; 324, Dr. Ballenden, ibid., p. 579, poisoning of three children by the same; 325, MS. Reports of St. Barth. Hosp., 1860 Month. Hom. Rev., vol. xiv, p. 428, Rachel and Emma Taylor, partook of a pudding containing a teaspoonful of white Arsenic; 326, Dr. Thomas Orton, Lancet, 1862 (2), p. 576, poisoning by paper; 327, Mr. Simon's Pub. Health Reports, Brit. Med. Journ., 1863 (2), p. 435, symptoms from Ars. green ; 328, Dr. D. McN. Parker, Edinb. Med. Journ., 1864, vol. x, p. 116, effects of Arsenic-eating on a man, æt. thirty years ; 329, Craig Maclagan, ibid., p. 200, effects of Arsenic-eating ; 330, R. C. Hamil, M.D., Chicago Med. Exam., 1865, p. 613, Mr. H., æt. twenty-five years, took 6 or 7 drachms in cold water; after half an hour an emetic and hydrated oxide of iron were given, vomiting produced ; 331, A. S. Taylor, Guy's Hosp. Rep., 1865, 277 (Berridge), poisoning of three children by Arsenic in vermin powder ; 332, Dr. Docherty, Glasgow, Mon. Journ. (Pbarm. Journ., 2d ser., vol. vii, 1866, p. 243), Mrs. Keechan took } oz. in milk; 333, Profs. Grote and Mosler, Berl. Klin. Woch., 1866, p. 60, a boy, æt. two years, ate a piece of paint; (334 to 339, from Berridge); 334, Dr. F. Duckworth, Madras Quart. Journ. of Med. Sci., vol. ix, 1867, 304, Arsenic in food; 335, Hutchinson, Lancet, 1869 (2), 508, general effects; 336, Dr. Seissei, Ærtz. Intell. Blatt, 1869 (Brit. Med. Journ., 1869 (1), 424), four hundred persons poisoned by bread; 337, Thomas Graham, Glasgow Med. Journ., 1869 (1), 56, poisoning; 338, Dr. Hicks, Lancet, 1870 (2), 356, a man, æt. forty-eight years, was engaged in pulling off wall-paper ; 339, Berridge, Monih. Hom. Rev., 1870, 430, a friend of mine suffering from skin eruption, took the 6th ; 340, Brit. Med. Journ., 1871 (2), 101, poisoning by wall-paper ; 341, Martineau, L'Union Med., April, 1873, p. 558, poisoning; (342 to 314, from Berridge); 342, Dr. Clement Walter, Brit. Med. Journ., 1873 (2), 700, a lady was poisoned by per ; 343, Dr. J. Liddell, ibid., p. 772, effects of wall-paper ; 344, Dr. John Morley, ibid., 88, poisoning of fifteen persons by Arsenic ; 345, Dr. Merbach, Vjs. für Ger. Med., 1875, p. 48, poisoning ; 346, H. S. Jones, M.D., Virginia Med. Month., 1875, p. 194, Jesse Thomas, æt. twenty-two years, swallowed vearly a teaspoonful; (347 to 372, from Tardieu, Étude méd. leg. et clin., sur L'Einpoisonnement, Paris, 1875); 347, Arsenic in milk; 348 and 349, other cases ; 350, Devergie, Med. leg., 3d edit., t. 3, p. 525, poisoning ; 351, same, a girl, æt. seventeen years, took 10 grams; 352, Dr. Lachèse tils, Ann. d'hyg. publ. et de méd. leg., 1re ser., t. 17, p. 340, a girl took a large quantity; 353, Laborde, Journ. de med.-chir. et pharm., 1787, p. 89, poisoning; 354, Bull. de la Soc. Avat., 1853, 179, a girl took a large quantity; 355, Aun. d'hyg., publ. et de méd. leg., 1847, 390, poisoning; 356, Dr. Bineau, Journ. des cours médl.-chir., 1835, 190, five children, from five to nine years, were poisoned; 357, Guilbert, Journ. de Van der Monde, 1756, 353, a man took a large quantity ; 358, Barrier, Journ. de méd., 1873, 353, five men were poisoned by a solution ; 359, Dr. Coquetet, Journ. des connais, medic. chir., 1839, p. 155, poisoning of three persons ; 360, Dr. Deville, Révue méd., 1838, 355, a woman took 3 grams; 361, Tardieu, poisoning ; 362, Dr. Martineau, communication to Soc. med. des Hôp., effects on a man; 363, Ann. d'hyg. et de méd. leg., 1847, 400, poisoning ; 364, Dr. Lachese fils, Ann. d'hyg. publ. et de méd. leg., 1re ser., t. 17, five persons were poisoned by soup; 365, same, case of a woman; 366, ibid., t. 37, p. 121 ; 367, Dehesne, Journ. de Van der Monde, 1759, 330, poisoning ; 368, Mean, Bib. méd., 1821, 401, application to the feet; 369, Desgranges, Rec. de la Soc. de méd. de Paris, t. 6, p. 22, application of arsenical pomade to the hair; 370, Belloc, Méd. leg., t. 4, p. 124, a woman applied a solution to the whole body; 371, Dr. Vernois, Ann. d'hyg. et de méd. leg., 1846, application of a preparation to a tumor; 372, Dr. Vitry, ibid., application of a preparation of Arsenic; 373, Dr. Netolitzky, Prag. Med. Wochn., 1876, 225 (S. J., 171, 138), a woman poisoned by a large dose; 374, Eduard Renner, Ueber einen Fall von chron. Arsengiftung, Würzburg, 1876; 375 and 376, E. W. Berridge, Am. Journ. of Hom., Mat. Med., New Ser., vol. v, p. 427, poisoning of two children by wall-paper ; 377 to 384, F. H. Brown, M.D., Bost. Med. and Surg. Journ., vol. xciv, 529, cases of similar poisoning ; 385, H. B. Dunkin, M.D., Brit. Med. Journ., 1876 (2), 587, similar case ; 386, A. P. Bowie, M.D., Hahn. Month., vol. xii, p. 490, John Adams swallowed } oz. dissolved in water; 387, J. H. Finley, M.D., New York Med. Journ., vol. xxvi, 1877, p. 401, poisoning of sixty men; 388, Dr. Ussher, Hom. World, vol. xii, p. 536, Mrs. S. poisoned by wall-paper ; 389, same, other cases of poisoning; 390, M. Saint Philippe, Gaz. méd. de Par. (Lond. Med. Rec., 1878, 215), oue patient took 16 grs., and another 6+ grs. Mind.- Delirium,358 359 366. — Occasional delirium,369

. Loss of reason from time to time, 367.—Previous to death the patient became delirious and restless, *** -Slight night delirium,190. — Delirious and unconscious, 29. — Became very nervous, agitated, and delirious, suspecting people were about the house plotting against his life, jumps out of bed suddenly and reaches after imaginary objects, and stares wildly and suspiciously around him, and at every one who makes the slightest noise or stirs; is incoherent,934:[2880.] Within two hours she was found sitting up in a chair, tossing her arms about, apparently perfectly uncouscious of surrounding objects and events. She seemed to be suffering from hysteria. Iu half an hour she was able to speak,25). —He pointed out to his sister a hollow between his breast and belly, into which she could have laid her arm, cited and crying (after one hour),265 — Much mental aud bodily agitation,236 --His head seemed very much affected, so that he scarcely kuew what he said or did, and seemed to labor under a kind of insanity, When spoken to she turned away her head, and was silent, 309. —Symptoms of intoxication immediately,333 - Arsenic-eating makes men lively and combative,329 — Feeling of impulsiveness,989. — Remarkable watchfulness, 317.

-[2890.) Great dislike and indifference to those around,206 — Extreme oppression,355. — Great depression and want of interest in anything, 914. —“The

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