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the amount of urine passed was decreased, the specific gravity increased, and the amount of urea decreased. The diarrhea continued through the 19th of same month, and the symptoms as depicted under stools in the proving were very marked. When the normal stools were restored, the concomitant symptoms passed away. Since the disappearance of the diarrhæa the stools are so large that they cause much pain in expulsion. They do not smell so badly as previous to taking the medicine.
Had a craving appetite; food seemed to taste very good.
For some two or three nights after taking the drug had profuse perspiration.
I also had much nausea, but not associated with much retching nor any vomiting during the whole time that I was under the influence of the drug.
Had more or less pain in the back.
Remarks on second test with 0 of fresh roots.—Since taking this last time to date (September 28th, 1877), my bowels have moved twice almost every day Stools normal and less fetid than before taking the drug. Have noticed considerable blood on waste paper quite a number of times. The muscles of anus feel relaxed. I have also felt bearing down in rectum as if going to have piles. Anus also feels as if open. Have also noticed more flatus than usual.
Much headache, especially in right temple, this was followed by vertigo and nausea.
Have had much pain in knee joints, and the lower extremities feel stiff.
Catching pains in heart, of a quick and sharp character. · Some palpitation.
Have lost four pounds since taking the medicine. Appetite exceedingly good and food relishes better.
I am inclined to think from the character of stools that the drug in some way influences the secretion of bile.
Remarks on the test with hot infusion of fresh roots with 10 per cent. alcohol. - The head and heart symptoms gradually diminishing to date (October 15th, 1877), are not now perceptible. Since the primary action of the drug on the bowels has passed away, I have had three passages almost every day, something very unusual for me, as my normal condition is only one passage per day, and that in the morning. During these days of which I speak I would feel bloated in the abdomen, with slight pains as if flatus were moving in different parts of the abdomen; this would be followed immediately by an urgent desire for stool. This desire was so sudden and urgent that I would fear that an accident might befall me. I had no control of sphincter ani muscle. These symptoms of stool always occurred immediately after eating. These stools were at times mushy, and at other times a little lumpy, associated with undigested food. These stools were painless, preceded by some pains of moving flatus, and followed by tenesmus and bearing down in rectum, even to protrusion. I have also noticed considerable itching in anus. After the stool a feeling of emptiness in abdomen and some protrusion; also the characteristic pain in the right temple.
My appetite was never better than during this time.
in the inferior angle of the scapula ; the latter pains at times are dull and aching and last quite a long time.
Litile boils on face and thighs.
I will now state (January 30th, 1878) that my bowels are regular, with one passage per day. The heart symptoms have all passed away, and the pulse is regular and normal. The only symptom that seems to remain is weakness of ani muscles; they still feel relaxed.
Authorities. 2, J. G. Blackley, M.B., Brit. Journ. of Hom., 1873, p. 497, injected 10 minims of 10 per cent. solution under the skin of the left arm; 3, same, injected to grain Hydrochlorate of apormorph., under the skin of the arm of William J., aged twenty-eight years; 4, Dr. Jurasz, Deutsche Arch. für. Klin. Med., 1875, p. 52 ; 5, M. Chouppe, Gaz. Hebdom., Dec. 1874 (Lond. Med. Rev., vol. iii, p. 57), general effects; 6, Dr. Brochin, Gaz. des Hop., Jan. 16th (ibid., p. 58), effects of the hydrochlorate.
Pulse 76; temperature 98.3° (normal); feels giddy; complains of pressure at epigastrium; pulse 88, weak, but regular; pupils moderately dilated (in four minutes); began to vomit slightly in five minutes); vomiting profusely, this continued for three minutes (in six minutes); ceased vomiting; took a drink of water, which came up immediately; milk was rejected in like manner; pulse 80, weak; temperature 98.6° (in nine minutes); still feels very giddy, and looks pale; pupils dilated (in sixteen minutes),--Pulse 72 (before experiment); 80 (in five minutes); 65 (in twelve minutes); 70 (second day),:-[10.] Temperature 98° (before experiment); 99.2° (in five minutes); 99.2' (in twelve minutes); 97.8' (second day),':--After three minutes the pulse began to rise slightly, and the respirations became slightly accelerated. At the end of four minutes I felt a sudden qualmishuess, which was almost immediately followed by nausea and profuse vomiting. This continued for several minutes, and was followed as soon as the contents of the stomach had been evacuated by severe retching. On taking a draught of water with a little brandy in it this was immediately rejected, and on drinking cold water this too returned at once. No bile, however, came up in the vomited matters. At the end of seven or eight minutes from the commencement of the experiment I began to feel very faint and was compelled to lie down, and almost on doing so fainted entirely, and remained in a state of syncope for about five minutes. On awaking from this I felt giddy and chilly, and was obliged to take a little brandy and water. This was retained, and as I began to feel slightly drowsy, I remained lying for the space of about one hour, during which time I perspired profusely. On rising I still felt slight giddiness, but no inclination to vomit. I went to bed and slept soundly all night, awaking about 8 A.M., in my usual health, slightly pale, but very hungry,?.-In two to seven minutes after the injection of a solution of 1 milligram under the skin the symptoms begin, usually with dulness of the head, sometimes described as a headache, sometimes as a simple heaviness or vertigo, often associated with roaring in the ears and feeling of heat. At times the patient is suddenly attacked by a feeling of anxiety in the præcordial region, or by a pressure in the chest. With the reaction there is generally an inclination to sleep, prostration, and loss of strength, and
in a few cases nausea and retching, beginning without warning. The relaxation during the prodromal state is at times very great, reminding one of collapse, frequently associated with profuse perspiration, salivation, and paleness, especially of the face. The vomiting comes on in from four to twenty-six minutes after the injection, usually in ten to fifteen minutes after a dose of 5 milligrams. Vomiting is very easy, without effort, or after the stomach has been emptied very difficult, and associated with eructations and retching. The vomiting will occur once or be repeated two to eight times, with greater or less intensity. Between the acts of vomiting the patient is usually quiet, feels very weak, yawns or perspires very freely. Sleepiness is frequently noted. The nausea continues, frequently associated with retching or eructations, and only ceases when there is no more to vomit. Between the acts of vomiting there is very great prostration and a pathy. The whole stage of vomiting varies according to the frequency of the act and the length of intervals between the acts, lasting from one to fifty minutes. After the cessation of vomiting the synıptoms gradually disappear; restoration is slow, the patient feels nauseated for some time, and weak and sleepy,'.-It appears from many experiments that A pomorphia produces vomiting by what channel soever it reaches the organism, but that its effects are more prompt and more certain when it is introduced directly into the blood by intravenous or subcutaneous injection. It given by the mouth, the dose must be increased, and the effects are less certain. During the two or three minutes immediately following the injection, the patient does not feel anything. Soon a sensation of weight at the stomach, followed by a slight pain in the head, comes on. Then salivation becomes copious, the body is covered with perspiration, one or two efforts at vomiting without any result occur, and at the third, or more rarely the fourth effort, the patient vomits three or four times successfully; then comes a period of calm. The vomitings return after an interruption of five or six minutes, followed by another interval of calm, and the same scene is repeated five or six different times, to terminate definitely at the end of about half an hour, and to give place to a very quiet sleep, lasting from half an hour to an hour,".- A woman, forty years of age, complained of gastric troubles without fever. After some days she was attacked by sore throat and complete anorex The tonsils were red and swollen and the tongue very much furred. A hypodermic injection of three or four milligrams of Hydrochlorate of apomorphia was administered to her in the sternal region. The pulse was full, and marked 100 beats. In four minutes the patient felt slight uneasiness and a little vertigo; she said she felt her head turning round and becoming stupid. She turned pale, became insensible, her pulse became extremely weak, intermittent, and then imperceptible; the pupils were dılated, and the respiration seemed to be entirely suspended. Slight tonic convulsions showed themselves in the left corner of the mouth and in the left cheek. The patient became inert and did not answer to the questions put to her. After spriukling with cold water, inhalations of ammonia, frictions, mustard poultices, etc., she recovered consciousness in three minutes and vomited twice, after which she again fainted, became extremely pallid, and the pupils were alternately dilated and contracted; these symptoms were afterwards repeated,
Sea-water causes constant hawking and raising of phlegm, white and tough, like cotton.
Authority. S. A. Jones, M.D., Hale's New Remedies, third edition, p. 471. At 3 P.M., I took 10 drops of the mother tincture in 2 ounces of water.
On retiring at 12 P.M., felt as well as I ever did. Had vo sooner laid down than I was seized with a fit of asthma. I had laid upon my back when the following symptoms had supervened : Dry wheezing respiration, sense of impending suffocation, and rapidly increasing dyspnea. Very loud musical whistlings during both inspiration and expiration, but louder during inspiration. The attack soon reached its acme, and phlegm began to come up. It was scanty, but each expectoration was attended with a sensation that more would soon follow. My wife now observed that my wheezing was so labored as to make the whole bed vibrate. Could not possibly lie down; felt that I would suffocate if I did not sit up. Phlegm began to come freer and more abundantly; had a markedly salty taste, and felt quite warm in the mouth. Right lung appeared to be more oppressed than the left.
When the worst of the attack was over I lay on my right side, and then it seemed as if all the oppression and discomfort was in the right lung. Shortly after I turned over, and soon it felt as if my left lung was affected, while the right was entirely relieved.
It took a long time for me to come to.” Had a constant desire to clear the chest of something, so that I could inspire better. All the obstruction seemed to be in inspiration. On making a forcible expiration, in the attempt to clear the chest, had a raw, burning, sore feeling behind the whole length of the sternum, and in each lung, most intense behind the sternum. Slept well all night. After rising in the morning, raised some loose phlegm easily.
I am inclined to asthma, and at first thought this one of its attacks; but as the phenomena were evolved, the programme was so different that my drink of Aralia flashed into memory.
On the night of the 28th, I was literally drenched with perspiration while asleep. Was wakened by a patient, when it passed off and did not recur.
29th. I have been annoyed all day by a dread that my right lung is seriously diseased. Could not shake off the fear. Cough now and then, raising a little phlegm, which is involuntarily swallowed. Took 10 drops of the tincture at 1.30 A.M. No symptoms that night. On rising at 8.30, bowels felt as they have done after a large-sized "spree.” Faintly defined nausea in throat and stomach, and sensation in intestines as if diarrhea would set in. At 3.15 P.M. went to closet, expecting from my feelings a loose stool. Evacuation was soft, yellow, about a teaspoonful in quantity, and expelled with great difficulty. Mucous inembrane of rectum came down like a tumor. (Have had hæmorrhoids.) After stool, and
while sitting on the "throne,” an aching paiu in the rectum, extending upwards, and on the left side.
Feel weak, prostrated, half sick, and filled with a vague nausea.
ARANEA. Authorities. 1, La. Clinique (Bost. Med. and Surg. Journ., vol. iii, 1830, p. 167), a lady applied a plaster made of equal parts of the domestic spider and treacle, for toothache; 2, National Recorder, Phila. (Am. Journ, of Med. Sci., vol. xix, 1836, p. 267), a man was stung by a spider on his foot, death ; 3, Isaac Halse, M.D., Am. Journ. Med. Sci., vol. xxiv, 1839, p. 69, Mr. Q., was stung on the glans penis by a large dark-brown spider, covered with hairs over the legs and body; 4, F. Grinnell, M.D., Cincin. Lancet and Obs., vol. xix, 1876, p. 900, Mrs. W., was bitten on the tongue by a black spider (variety, Saltacus familiaris).
In ten to twelve hours, the hand, forearm, and lower half of the arm became swollen and extremely pallid, of a dark-yellowish color, and corered with a multitude of vesicles, accompanied by fever and anxiety. These symptoms lasted for six weeks, '. - The next day the lymphatic streaks were perceptible as high up as his knee, on which was a purple swelling, -In one hour, writhing under the most acute suffering. Vomiting with great violence, and complaining of deepseated pain in the abdomen, extending up into the chest, and of sensations of choking' and suffocation. The vessels of the back and neck were greatly distended, and of a dark hue. Pains and spasms along the spine and extremities, ".--Instantly a painful sensation, as though arising from several points, darted along the tongue, painfully affecting the tongue, jaws, and head. The effects were instantaneous, and were compared to a shock from an electric battery. The tongue seemed almost paralyzed, the utterance thick and heavy, and the pains at the root of the tongue and in the lower jaw, especially at its articulation with the temporal bones, were most excruciating,".
Barham, Hort. Amer., p. 152 (Pharm. Journ., vol. iv, p. 167), a negro smoked a quantity of the seeds.
Before he had smoked out his pipe, he fell into a sound sleep; not easily awakened.
ARGENTUM NITRICUM. The following, taken from the original, is deemed worthy of insertion, in place of the fragmentary reference in volume i.
Das silber, Arzn. betrachet. Dr. Krahmer, Halle, 1845, p. 84. Quoted experiments of Schachert, Diss. de usu Argenti nitrici intermo, Regimont, 1837.
He took grain of Nitrate of silver in distilled water, frequently repeating the dose; slight burning in the stomach. Afterwards took į grain,