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region after stool. Urine expelled with little force, as if muscles were relaxed and had lost power of action. Pain in joints at times quite severe, also pain in left scapula at inferior angle.

I stopped taking drug September 1st, and did not commence to prove again until September 28th, 1877.

Test with hot infusion of fresh roots containing 10 per cent. of alcohol.September 28th, 1877. Weight at this time 146 pounds. Respiration 17. Just before retiring, took ounce of the above-named. Soon after much nausea, but no vomiting.

September 29th. Respiration 16. Pulse 68, and regular in morning. At 7 A.M., took ounce of same. Nausea returned. A rumbling aud weak feeling in lower bowel. Headache commenced in right temple, then sharp stabbing pains, followed by confused feeling in head, and then vertigo. Aching pain also extends to meatus auditorius externus. Urine slightly acid. Stool easily evacuated and mushy at end of passage. Heaviness of rectum followed by tenesmus after stool. At 10.30, took : ounce of same. Feeling of goneness.

Severe pain in head. Arms, apparently loss of muscular power, feel as though they could not be moved. Pains in joints reappear. At 2 P.M. took į ounce of same. About twenty minutes after the pulse 60. Dr. Boynton, Assistant Surgeon to New York Ophthalmic Hospital, thus describes the pulse: Full, irregular, slow, intermittent, dicrotic, three regular beats, then intermission, then two beats, then one; intermission, then one; intermission, then can count four beats; irregular; at times feeble, readily compressed; then slow. A short time after, Dr. Wanstall, Resident Surgeon of same hospital, listened to chest and found that the heart was beating regularly for a short time, then fluttering occasionally and very feeble, and then it seemed to be slow and labored, now and then losing a beat; he also noticed a clicking sound, for which he could not account. During the afternoon and evening, felt slight darting pains in region of heart. A feeling of prostration or weakness near the heart. I would have to take a deep inspiration in order to get breath, for I felt so suffocated. After these sensations, flashes of heat followed by perspiration. Had stool, with much tenesmus. Heavy bearing-down feeling in rectum. At 5.20 P.m. pulse for first half of minute 18 beats, and last half 32, making a total of 50 per minute. Respiration 18

Pulse at 6 P.M. 66; had tracing taken at this time. The tracing showed marked intermissions. I had the pulse watched closely and it continued to intermit that day and night. The action of the drug on the heart was so violent that I was fearful of taking any more of it at this time. I did not know but paralysis of the heart would follow, as the pulse was reduced so much below its normal condition. Sleep this night not impaired. Symptoms aggravated by motion.

September 30th. On rising, the pulse at 60. Respiration 17. The pulse was now more full and regular than the previous day. Stool not normal but soft and mushy, and of a lemon color. Much Alatus. Prostration after stool not as marked as when I first took drug several weeks before. Pain in region of heart returned, accompanied with feeling of weakness in that region. Sensation as if heart beat slowly, then fluttered, and followed by regular beats. At times could distinctly feel impulse of heart against walls of chest. Sharp pain at intervals in interior angle of scapula of lett side. Head symptoms continue, but not as much vertigo. More or less aching in joints. Whole system feels weak.

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UNDER INFLUENCE OF INFUSION OF FRESH ROOT PREPARED WITH TEN

PER CENT. OF ALCOHOL,

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The increase of P,0; on the 2d is owing possibly to the eating of oatmeal on the forenoon of Sunday, also on the following morning.

Remarks concerning my first test of the 0 of the fresh roots.- Please notice that the drug was first taken on the evening of August 13th, 1877, just before retiring, and the amount of urine passed the day following (August 14th) was slightly increased over the average of the normal amount. The specific gravity less than the average, and the amount of urea increased. The second day under the influence of the drug there is increased amount of urine and a marked increase in the secretion of urea. The third day more marked increase in amount of urine passed, and the amount of urea nearly the same as the second day. Also notice that on the morning of the third day (August 16th) I took the largest dose, and that dose was the last taken during this test. The day following (August 17th), amount of urine less than during the three preceding days while taking drug; also a decrease in secretion of urea that day (August 17th). This same decrease was marked for some two days after. Hence I conclude that during the three days while taking drug (August 14th, 15th, and 16th) the average amount of urine was increased; the specific gravity decreased, and the amount of urea also increased. And the observations during the two days following the stoppage of taking the drug show that

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