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drooping of the eyelids. Coldness was sometimes perceptible in the hands and feet. Frequent call to stool, four or five times during the day; the stools were soft and copious, being passed with little pain, with a general feeling of relaxation. Discharge of much urine, with the same sediment as before mentioned, which was found to coagulate by heat, and in very many respects resembled albumen.

The tonsils and throat, for a day or two, seemed coated with mucus which had dried upon them.

Proving No. 2.—Dec. 15th, 10 P.M. 1 drop in a teaspoonful of water. Slept as usual.

Dec. 16th, 9 A.M. One hour after breakfast, dose as before. Immediately after taking a slight burning sensation on the red part of upper lip. Slight nausea, which soon disappeared. Two hours after each meal the e was experienced a very distressing oppression at the epigastrium; also a sensation as if there were a working in the stomach. This symptom lasted about two hours, and then disappeared.

Dec. 16th 9 P.M. Two hours after a meal, dose as before. Slept as usual.

Dec. 17th. Morning before breakfast, 2 drops in a tablespoonful of water. The same sensations at the epigastrium as yesterday. Evening, 2 drops, as before. Here it was taken purposely on an empty stomach to ascertain positively if the effects produced would be similar to those previously experienced. About ten minutes after taking it a similar sensation of distress at the epigastrium was experienced, and to such a degree as to compel me to leave my sitting posture and walk about, wbich gave me some relief. In the evening after taking the drug, about three hours after a meal, not so much inconvenience was produced as when the medicine was taken on an empty stomach.

Dec. 18th. After breakfast, dose as before. Felt better to day; distress at epigastrium less. 9 P.M., 5 drops in a teaspoonful of water; soon after taking it a sensation of working in the stomach, as from wind, with empty eructations, after which relief was experienced; slight pinching pains in the epigastrium, shooting from right to left. Slept as usual.

Dec. 19th, A.M. and P.m. 5 drops two hours after meals. No marked impressions, save that the epigastric symptoms were about the same.

Dec. 20th. Five drops two hours after breakfast; slight nausea soon after taking the drug, which was of short continuance. Felt less distress at the epigastrium to day. P.M., 10 drops in a teaspoonful of water, soon after there was a rumbling in the abdomen, and the peculiar sensation of working in the stomach ; several short pinching pains across the middle of the abdomen. Sensation, as if a ball were pressed against the inside of the wall of the stomach, at the pyloric region. Slept as usual.

Dec. 21st. No medicine. Felt uncomfortable to-day, on account of above sensations.

Dec. 22d. No medicine. Symptoms beginning to disappear.

Apocynum cannabinum. Edward Chapin. Thesis presented for the gold medal, N. Y. Hom. Med. College, 1878.

Proving of Louis Faust, M.D.-Age twenty-one years. Normal pulse 66. Normal amount of urine passed every twenty-four hours, thirty fluid ounces. Average specific gravity of the same 1028. Color of hair brown; dark complexion ; eyes gray. Habit, strictly temperate.

Commenced the infusion of the tops of the fresh plant July 20th, 1877, at 3 P.M. ; took ļoz. with no effect. July 21st. At 8.15 A.M., took 1 oz. Soon after slight nausea,

which soon passed away. At 11.10 A.M., burning pain in the stomach, causing me to feel uneasy: Shooting pain in right ear, lasting over one hour. °(Have never before been troubled with earache.) Urine for the twenty-four hours 40 ozs., and specific gravity 1020. At 4 P.M. took 1} ozs.

July 22d. Took none. Urine passed during twenty-four hours 36 ozs., specific gravity 1022.

July 23d. At 5 P.M., took 2 ozs. Soon after singing I had partial deafnees in left ear, which continued over one hour, with occasional sticking in same ear. Urine for twenty-four hours 24 ozs., specific gravity 1025.

July 24th. Was restless all night; have had temporal headache all day, with heaviness and pain in my eyes, as if I had used them too much, although I have not used them more than usual. At 4.30 took 2} ozs. Urine, twenty-four hours, 30 ozs.; sp. gr. 1028.

July 25th. Same heaviness over eyes as yesterday. Have had ravenous hunger since commenced proving. Get hungry an hour before mealtime. Bowels have a tendency to be loose. At 7 P.M. took 3 ozs.

July 26th. While at breakfast was taken with violent pain in abdomen, which continued until I had a passage. The stool was very soft, painless ; relief after stool, but have felt weak all the morning. Face pale, with cold perspiration. Rumbling in the abdomen. Urine, twenty-four hours, 42 ozs.; sp. gr. 1024. No medicine.

July 27th. Passed a very restless night. Have an uneasy feeling in my abdomen, but no tendency to stool. Urine, twenty-four hours, 23 ozs.;

July 28th. Great weakness in my stomach. Although I eat hearty meals I get hungry long before the next. Bowels still loose, they seem to be loose generally in the morning, as I have had no passage in the afternoon since proving. Stools painless. Urine, twenty-four hours, 24 ozs.;

July 29th. Same uneasiness in stomach. Urine, twenty-four hours, 34 ozs. ; sp. gr. 1022.

July 30th. The uneasiness and weakness in stomach have increased to a gnawing this P.M.; it commenced about an hour after dinner. I feel as though I was constantly being threatened with an attack of cholera morbus. (I am very careful in my diet.) Urine, twenty-four hours, 24 ozs.; sp. gr. 1028.

July 31st. Bowels are natural, but the same sensation of gnawing and hunger continues in stomach. Urine, twenty-four hours, 24 ozs. ; sp. gr. 1028.

August 1st. Although I ate a hearty breakfast I have now (10 A.M.) that gnawing in my stomach. Urine, twenty-four hours, 34 ozs.; sp. gr. 1020.

August 2d. Feel well to-day. The gnawing and hunger have left me. Bowels are natural. At 5 P.M. took 2ozs. Immediately after nausea, which soon passed away.

Had peculiar sensation in thorax, causing me to sigh constantly. Proving of Byron E. Mead, med. student, age twenty-four.-Weight

sp. gr. 1026.

sp. gr. 1028.

148 lbs. Height 5 ft. 5 in. Sanguineous temperament. Hair black. Complexion fair. Eyes black. Temperate in habit. Pulse full and strong, average about 73 beats per minute. At the time I began this proving, was in a good state of health. Bowels regular, one passage per day, stool of ordinary size; for urinary record see tables at the end.

Preparation, cold infusion of the fresh root.

June 19th, 1877. At 10 P.M. took } oz. Retired at 11 P.M., having felt no effect from dose. Slept well during the night, and on waking in the morning felt rested and refreshed, and ready for my morning meal.

June 20th. At 7.30 A.M. took 1 oz. upon going to breakfast. No effect. At 8.30 took 1 oz. About one hour after taking last dose felt sick, with an inclination to vomit; also frontal headache, pains darting, passing from one temple to the other; first, from left to right, and vice versa. At times feel dizzy, sensation as if I was going to tumble over. Vertigo coming quickly, and passing away as suddenly. This last-named symptom is a very marked one in my case, as I am never subject to vertigo unless it can be traced to some definite cause. I also feel dull and unable to think well. Cannot fix my thoughts on any one subject, and retain them for any length of time. At 11 A.M. took 1 oz. Symptoms same as before, excepting the nausea, which was more marked, and remained longer.

Hot infusion of the root. (Had no more of the cold.)

June 20th. At 1.30 P.M. took 2 ozs. of hot infusion of root, and at 2.20 P.M. was taken suddenly with intense tenesmus, and the desire for stool so great that I was compelled to leave the drug-room and get to the watercloset as soon as possible. Stools large and light yellow, accompanied by runbling in the bowels, and flatus. There seems to be almost complete loss of power of the sphincter muscles of anus. After stool, considerable nausea and frequent desire to vomit, but did not. At 5 P.M. passed another large stool, accompanied by great rumbling in bowels, and flatus. Also frontal headache, with sharp, darting pains. Pain in right shoulderblade. General muscular weakness. Feeling of lassitude. At 6 P.M. took 2 ozs. After taking the dose went to dinner, and while there was taken short, and passed an exceedingly large stool (in water-closet) light yellow, fetid, with great flatus and the same rumbling of the bowels. Same frontal beadache, and constant flashes of heat; face looks flushed and hot. Respiration affected, slight suffocating feeling. Hungry all the time, could eat every hour in the day, relish all kinds of food, and seem to digest them well. Rheumatic pains in the joints. Increased action of the heart, fluttering at times, and sensation as if it would force its way out through walls of chest.

June 21st, 7 A.M. Have passed a good night, slept well, and feel refreshed, and ready to take my regular morning meal. At 10.30 A.M. took

About an hour after had a sudden desire for stool, aud passed a large one of same color as before, and accompanied by same rumbling and flatus. Impossible to tell when I am through passing, for I get up from water-closet and think that I am through, and another pain takes me, compelling me to hurry and sit down agaiu, and nothing passes but wind. No headache to-day, but considerable vertigo, feel as if I were going to tumble over. Pain in orbital region, and dull heavy feeling over the eyes. General lassitude. No ambition. Cannot concentrate my thoughts. Burning sensation in anus. Complete loss of power of sphincter muscles. At 1.30 P.M. took 2 ozs. About one half hour after had an urgent desire for stool, preceded by intense pain in bowels. Passed a large mushy stool, and lots of flatus. Sphincters seem to be relaxed, and cease to perform their proper function. Urine burns when passing, and feels hot. Head dull, beavy feeling in forehead and heaviness over the eyes. Slight vertigo. Some pain in right shoulderblade, and in muscles of forearm. Cannot conceutrate my thoughts. At 4.30 P.M. desire for stool, but in trying passed nothing but flatus. Slight dull pain in region of kidney. Slight palpitation of the heart. At 6.30 P.M. feel too tired to go to dinner, but am exceedingly hungry, and will go. Ate a hearty meal, and when I got through my hunger seemed unsatisfied. On returning, desire for stool, accompanied by flatus and rumbling; passed a large mushy stool, which was light yellow. Soreness and bearing down in rectum.

2 ozs.

June 22d. Feel exceedingly weak this morning, limbs and muscles feel sore ; slept well last night, but do not feel rested. Appetite good. Had one passage this A.M. on getting up, and of the same nature as before. Burning in the anus. Bearing-down sensation, inclination to hæmorrhoids.

6 P.M. Have not taken any medicine to-day. Have had four passages since morning, and feel weak and tired. Pain in joints nearly all day, also frontal headache.

June 25th. For the few days past my bowels have been very loose, having from three to four passages per day, and nearly every one accompanied by flatus. Appetite good all of the time and no unpleasant effects after eating.

At 10.30 A.m. took 2 ounces cold infusion of tops. About an hour after felt sick at stomach, and desire to vomit. Frontal headache and vertigo. 1.30 P.M. Have just returned from lunch and feel urgent desire for stool, accompanied as before by rumbling in bowels and flatus. Stool large, thin, and watery, bearing-down pain in anus, and soreness in rectum. General muscular weakness and inability for labor. Some frontal headache and very marked vertigo. 3 P.m. Desire for stool so intense that I had to run from the drug-room to avoid an involuntary evacuation ; passed a large, thin yellow stool and a great deal of flatus. Soreness in rectum and bearing-down sensation. Strong inclination to vomit, but have not as yet. Pain in right shoulderblade and in muscles of forearm. Heaviness over eyes and general lassitude. At 6 P.M. Have just had another stool, but very small

, and no rumbling in bowels. Sphincters still relaxed. Frontal headache and heaviness over the eyes. Increased heart's action and flushes of heat to the face.

June 26th. Slept exceedingly well last night, and feel rested this morning.

General Remarks. Have noticed that my bowels were loose for some two or three weeks after taking the drug, and I had two or three passages per day during that time. I have also noticed a bearing-down pain in rectum and strong inclination to hæmorrhoids. The relaxed condition of the sphincter muscles lasted for some three weeks. The effect on the system was so great that for months after the mere smelling of the drug would make me feel sick at the stomach.

Proving of J. Clark, M.D.-Age thirty-four. Height 5 feet 9 inches. Weight 155 pounds. Color of hair brown, of eyes hazel. Habit temperate. General health good. Complexion dark and of a bilious temperament.

Used 0 of the whole fresh plant. August 23d, 1877. At 6 P.M. began with 3j doses every two hours ; was called to an obstetric case and did not get second dose until 9.15 P.M., and then at 11.15 P.M.

August 24th. Took dose at 8 A.M., felt a slight burning sensation in stomach while at breakfast. Took it every two hours all day excepting at 2 o'clock. To-night have nausea almost to vomiting, and slight headache. Have an unpleasant grumbling in bowels, but not much pain with diarrhæa.

August 25th. Both this and yesterday morning had some vertigo on rising from stooping posture. Had furious diarrhea last night, painless. I did not want to leave the water-closet when I was through, more from a sense of weakness than otherwise. Began this morning at 8 o'clock to take medicine. Don't feel very well this A.M. Abdomen feels as though I had drank large quantities of water.

Evening of the 25th. Have not felt well all day, sick at stomach again to-night. Had hiccough both last night and this morning. Have felt very tired and weary all day. Nausea worse at night about 7 or 7.30. Had a severe pain when walking, in lower part of left lumbar region. Did not take drug very regular to-day, I was too sick. Had three passages through the day but none last night.

August 26th. Commenced again to take medicine at 4 P.M. Have taken three doses and feel very sick. Want to vomit but can't.

August 27th. Stools thin, light lemon-yellow, mixed with mucus, large in quantity. Don't dare to pass wind or water for fear that fæces will pass ; twice thought that I would allow wind to pass when a small quantity of fæces passed. I lost confidence, and so quit. Have been very sick all day, so much so, that I have not taken any medicine since 12 o'clock, poon. Have been covered with slight perspiration. Stools this evening as well as during morning frothy, rather more watery, light yellow as above. Have felt weak and exhausted throughout.

August 28th. Was not called up to water-closet last night. This morning mouth dry, tongue sticking to roof of mouth. Still have a little nausea. Vertigo on rising from stooping position. Although twenty hours have passed since I took last dose, still when I thought I would allow a little wind to pass, fæces came instead. Stools still quite watery. One symptom I have noticed several times, viz., when urinating I hardly know when through, the urine still seems to want to pass, or dribble away. My bowels were not back to their natural condition for sixty hours or two and a half days.

Proving by Alfred Wanstall, M.D. - Age twenty-five. Weight 163 pounds. Height 5 feet 8 inches. Pulse during health 54 to 60 beats per minute, at times intermitting. I kept no record of my pulse during the proving, as it is very variable, sometimes as low as 50 beats per minute, and I suffer with some heart symptoms, produced I believe by smoking. General health good, bowels regular. Color of hair brown. Eyes dark blue. Complexion dark. I am not easily influenced by medicine.

June 19th, 1877. At 9 P.M. took ounce cold infusion of root. At 11 P.M. took 1 ounce of same.

June 20th. At 7.45 A.M., 1 ounce of same. Increased appetite, even hunger. Smarting and burning in urethra while urinating. At 8.30 a.m. took 1 ounce of same. One hour later feeling of fulness in forehead and vertigo, passed away in a few seconds. Passage from bowels this morning not as copious as usual, and more difficult of expulsion. (I am always regular in this respect.) At 10.30 A.M., took 1 ounce of same. Dull frontal headache through the day. At 2 P.m., prickling and tingling in and

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