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prostrated. The eyes were surrounded by blue rings, and lay deep in their sockets. The headache left me for only short periods. The difficulty in swallowing had entirely disappeared. Pulse 69 and 70.

September 12th. I made a new experiment; I injected a solution directly into a vein. For this purpose I took a concentrated solution, and injected it into a superficial vein in the left forearm, $ ccm. of a strong so. lution, amounting to 5 mlgms. I had scarcely emptied the syringe when I experienced a raging headache, saw sparks of fire, had burning heat in the face, and distressing pressure in the brain; at the same time there was violent præcordial anxiety. I suffered from dyspnea, it became black before the eyes, I reeled, so that I was obliged to sit down ; I vomited green masses with great effort. At the same time there was very free hæmorrhage from the place of the injection, which was stopped only by persistent compression. Through the day I felt very weak, as after a terrible illness. Unfortunately it had been impossible to count the pulse, on account of the violence of the symptoms.

September 13th." Headache and pain in the stomach continued; therefore I took only 7 mlgms., after which there was nausea but no vomiting. The pulse rose within thirty-four minutes from 75 to 79, and an hour later fell to 70. Little appetite. On this day slight diarrhæic stool.

September 14th. I injected about it centgm. into the left forearm. Pulse 68. There was inimediately violent burning at the point of injection, which became very red. The face became hot; I experienced violent headache in the vertex and pressure in the brain, and a very anxious sensation in the pit of the stomach, nausea, retching, chilliness, and after twenty-five minutes vomiting of green masses, with outbreak of copious perspiration. Pulse 80, very small. The whole day I was very weak and unfit for any effort. On the two following days I could not make any experiments, but the headache continued, there were sensitiveness in the epigastric region), complete loss of appetite, and diminished power of digestion.

September 17th. In the morning I drank 1} centgm. The condition was tolerable. Pulse 72. After half an hour symptoms previously observed returned. Pulse 83. Headache and weariness lasted through the day. Sleep at night short, restless; diarrhoea.

September 18th. In spite of the unpleasant remembrance of the former injection, I attempted it again, injecting centym. directly into a vein on the left forearm. Pulse 75. This was followed by frightful beadache, heat of the face, vision of sparks, very anxious sensation in the stomach, in short, the same symptoms as after the former injection. On this day I examined my urine with Nitric acid and under the microscope. After the Nitric acid there was slight turbidity, and I found under the microscope desquamated epithelium of the uniferous tubes. This appearance of albumen in the urine warned me, on account of Mayrhoffer's proving, that I must discontinue further experiments on myself. The turbidity of the urine lasted two days; the pain in the stomach and head and difficulty in swallowing disappeared after three days, and the appetite returned. But even after two months there were frequently recurring troubles in digestion, reminding me of my proving. It was noteworthy that during the proving I lost seven pounds in weight, -Immediately experienced a metallic taste in the mouth. In a short time she felt sleepy and powerless ; black specks floated before her eyes, and she had to go to bed, where she lay rolling about and became faint, with cold perspirations. At 3 P.M. she vomited her dinner, and was purged, and again vomited two or three times. She had pain in the lower part of the abdomen, with severe cramps in the lower extremities. At 5 P.M. she was in a state of extreme prostration, with tetanic spasms of the legs. With great difficulty the legs were straightened, which gave great relief. She suffered from enteritis for about three weeks, and gradually recovered. The only other effect of the poison was that the hair began to fall out soon after the illness. She is now alive and well, but the hair on the crown of her head is very thin, 66. — Violent vomiting; violent and frequent recurring cramps of the legs, relieved by forcible extension,as.

APIS.

Authorities. 25, Ediub. Med. and Surg. Journ., vol. xiii, 1817, p. 130, James G., aged thirty nine, was stung by a bee on the middle finger of the left hand; 26, Drs. Bell and Ritchie, Am. Journ. of Med. Sci., vol. xix, 1836, p. 266, a man, aged twenty-six years, was stung by a bee on the under side of the tip of the nose; 27, Dr. Krieg, Caspar's Woch. (Lancet, 1812–3 (2), p. 654), a man, aged sixty years, was stung in the centre of the cornea by a bee; 28, G. H. Spalsbury, Bost. Med. and Surg. Journ., vol. liii, 1855, p. 285, Mrs. H. was stung by a honey-bee on the left fore. finger (she had ulcers in her mouth produced by kreasote); 29, Dr. N. Nivison, N. Y. Med. Journ., 1857, p. 339, a farmer, aged fifty years, was stung by a bee on the side of the neck, death on the sixth day; 30, C. Hanbury, Jr., Med. Times and Gaz., 1860, p. 233, Mr. J. was stung behind the ear; 31, M. Monquin-Tandou, ibid., quotes the case of a man, aged thirty-six years, who was stung on the back of the right hand by three or four bees; 32, John Ewens, Med. Times and Gaz., 1860 (2), p. 359, a inan was stug by a common bee below the right ear; 33, same, Lancet, 1872 (2), p. 437, an elderly lady was stung; 34, E. W. South, M.D., Am. Journ. of Hom. Mat. Med., vol. vi, 1873, p. 18, a man, aged thirty-five years, was stung twenty-seven times by bees; 35, H. King, M.D., Ohio Med. and Surg. Rep., vol. vii, 1873, p. 285, Mr. W. S. aged fifty years, was stung on the back of his hand ; 36, Dr. James Kitchen, Am. Journ. of Hom. Mat. Med., vol. vi, 1873, p. 249, a farmer was stung in nine places by honeybees; 37, George Walker, Lancet, 1874 (2), p. 833, the writer was stung on the forearm by a bee ; 38, Bull. de la Soc. Med. de la Suisse Romande, 1874, No. 8 (Hahn. Month., vol. xi, p. 506, 1876), a boy, aged eighteen years, was stung in the middle of the right palm; 39, E. W. Berridge, Am. Journ. of Hom. Mat. Med., vol. ix, 1876, p. 246, Miss stung by a bee on the forehead; 40, Dr. Tinker, copied from MSS., Mrs. A., aged forty years, not pregnant, for abdominal enlargement and cessation of menses, took 15 drops tincture, and repeated the dose after three hours.

The conjunctiva was greatly hypertrophied, and the cornea covered with a dense opaque layer of membrane. There was every reason to believe that the internal structures also, fully participated in the diseased process. On closely examining the eye a dark and slightly prominent spot was discovered in the centre of the cornea, around which much vascular injection was perceptible, and from this spot was extracted a long filiform body, the sting. The inflammation soon began to subside, but some striking results became permanent in consequence of the injury. The tint of the iris had changed from its natural grayish blue to a perfect blue, the pupil remained

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dilated and immovable on the stimulus of the light, and the patient, who before the accident was obliged to use convex glasses, now required one concave, being nearsighted on the left side, 27. — Very soon after, he became faint and began to vomit, which was repeated nine times, his bowels also were relaxed, though he did not mention how many times, 36 -Shortly after attacked by sharp crampy pains in the stomach and abdomen, followed presently by severe vomiting and diarrhea, which lasted at intervals for about two hours, and which simulated closely an attack of cholera morbus,".— Nausea, followed by profuse vomiting (second day); breathing oppressed and sighing (third day); diarrhea; countenance shrunken, wan, and anxious; pulse reduced in force and volume; tongue covered with a dirty white fur, pale, soft, and flabby (fourth day); sleeplessness; great restlessness and jactitation,”. — Vomiting ; slight spasm or convulsion ; pulseless and breathless; lips livid ; mouth open ; eyelids closed, pupils insensible to light; skin cold and clammy. System very much relaxed, urine passed in voluntarily. On the skin of the extremities, small purple spots, about three or four lines in diameter, nails on fingers and toes purple, and skin on feet the same,30 Soon after the sting there was faintness, vomiting, and purging, followed by prolonged fainting and low pulse, with repeated rigors and profuse sweating. On another occasion there was a severe attack of asthma in addition to the other symptoms,2.-He was instantly affected with an indescribable sensation over bis whole body, with a prickly feeling, and white and red spots in the palms of his hands, and on his arms and feet. Tears at the same time involuntarily flowed, the nose and face swelled, accompanied with hoarseness, loss of taste, oppression at the pit of the stomach, and difficulty of breathing. On his way home, which was distant about half a mile, he felt a great disposition to sleep, with increased difficulty of respiration, and by the time he reached his house, his face, throat, breast, and limbs were considerably swelled, with an increase of the other symptoms. He was soon seized with chilliness, cold extremities, and nausea, * -Immediately on receiving the injury, she put her finger to her mouth iu order to relieve the pain by suction; in a few moments she felt a prickling sensation in the lips and tongue. This seusation extended rapidly over the face, temples, and head, thence over the entire body; the sensation now resembled the pain in the finger from the sting. A few minutes after the accident happened, there was a good deal of tumefaction of the face, so much so, that the eyes were nearly closed, and the lips and tongue were so much swollen, as to interfere with speech. There was distressing sensation of fuluess in the head, the patient declaring that her temples would burst. She complained of oppression at the chest, and inability to take a fuil inspiration ; the skin was intensely red, and covered with an eruption over the entire body, except the feet, resembling urticaria, causing distressing itching and prickling. There had been severe rigors. Pulse 87 and full,26 – Immediately seized with obscuration of vision, loss of strength, profuse perspiration over the whole body, suffusion of the face, acute pain in the head, oppression, anxiety, and fear of death ; urticaria, with swelling of the lower extremities, and intense fever,"'. — 1990.] In twenty minutes he began to experience a sensation of itching, almost intolerable, in the ears, first the right, then the left. The right hand then felt benumbed, and this was followed immediately by intense itching of the palm, and the pulse was discovered to be very feeble. Then the skin of the forehead and face felt full and constricted, and began to swell, and red streaks made their appearance on the face. Gradually the swelling extended to the body and extremities, and the whole surface was covered with an eruption resembling urticaria. At the same time all symptoms of a collapse developed (first day). Feels dull, sleepy, and complains of lassitude, and a rumbling sound in both ears, and a general confusion, also incapability of fixing his attention on a book requiring thought (second day),"? - In a few minutes he was seized with nausea and vertigo, and a general sense of distress and prostration, accompanied with mental anxiety. When seen by me within half an hour, he was lying on his back with flushed and slightly puffed face and ears, and flushed neck, breathing with some difficulty, a sense of fulness and choking as if filling up his throat; oppression over the chest and epigastrium, troublesome itching or stinging of the face, ears, and throat, and also of the hands and wrists, feet and ankles. There was little or no itching on any other part of th body. An examination of his limbs discovered a marked redness of the hands as far as the wrists, and of the feet and ankles, pone farther up the limbs. The itching on the limbs seemed to be confined to the backs of the hands and the upper part of the feet. The pulse was quick and full, not hard. An examination of the place where he was stung showed that the bee had struck directly upon a prominent vein on the back of one of the hands. There was no swelling at this point. The precise order of development of all the symptoms could not be accurately ascertained. He suffered in this way about two hours, and then the symptoms gradually disappeared,$5. — The whole forearm was affected with a cutaneous erysipelas, and there was disorder of the nerves, accompanied with heat, redness, swelling, and pain,99:- Immediately after the first pain from the sting he was taken with a very intense itching, which very rapidly extended up his arm and over the entire upper part of the body; ten minutes later in a cold bath, the itching assumed an intolerable intensity ; very intense headache, rumbling in the ears, appreciable diminution of hearing, rough and laryngeal voice (perhaps caused by emotion); excitement approaching delirium. The trunk, arms, and the entire surface of the thorax were overspread with a very intense erythematous redness, the body appeared bloated, and the conjunctiva were injected. Pulse weak and very quick. Washing with ammonia diluted with water gave great relief, but could not be extended to the thorax as the ammoniacal fumes prevented respiration. At a quarter after two, the pains in the head continuing, a mustard bath was administered to the feet, which immediately caused an erythema of the lower extremities, identical with that of the upper part of the body. At 4 o'clock vomiting, which relieved bim, and was followed by sleep. At 7 o'clock notable diminution of the eruption on the arms and chest; the head was still free from it, but it was still very prominent on the limbs. Slight headache. He had a very agitated night, and the next day there was a little dulness of the head, and some red spots on the extremities. In the evening the symptoms entirely disappeared, —White swelling of the forehead and face, so that her friends did not recognize her, with pain in the forehead, and nausea,59: — The next morning the second right finger began to swell (except the tip), the middle joint especially, red, hot; burningstinging pains, with tingling extending up arm to body, and down right side and leg to foot; the pains were worse from sundown (5 P.M.) to 6–8 A.M., preventing sleep; relieved by hot applications and gentle rubbing, or by pinching end of finger, aggravated by cold applications. Constant and persistent aggravation from Apis 30th, 200th, and 1000th. Improving under Ledum,“'.—General malaise; severe attack of nettlerash, 13.

APOCYNUM CANNABINUM.

A pocynum cannabinum. John H. Griscom, M.D., Am. Journ. of Med. Sci., vol. xii, 1833, p. 55. General effects.

Its first operation when taken into the stomach is that of producing nausea, if given in sufficient quantity (which need not be large), and if this be increased, vomiting will be the result. It very soon evinces its action upon the peristaltic motions of the prima viæ, by producing copious feculent and watery discharges, particularly the latter, which action when ouce excited is very easily continued by the occasional administration of a wineglassful of the decoction. The next operation of this remedy is upon the skin, where it displays its sudorific properties often in a very remarkable manner. Copious perspiration almost invariably follows its exhibition. The activity of its diuretic properties does not appear to be so great in many instances as in others. As a sternutatory also it has a very powerful effect, as I have experienced in my own case; the fumes, on one occasion, produced not only long-continued and violent sneezing, with an increased discharge from the Schneiderian membrane, but were unquestionably the exciting cause of an attack of erysipelas of the face and head.

Proving No. 1.-Apocynum cannabis. Essay, submitted to the Faculty of Hom. Med. College of Penda., by Wm. T. Helmuth. 1853. Proving.

The tincture was obtained by digesting the fresh root in alcohol, and afterwards expressing the juice.

Shortly after taking half a teaspoonful of the tincture, a feeling of nausea was experienced, which seemed to commence at the throat, and extend downward to the stomach; this symptom continued for nearly an hour, however there was no inclination to vomit. There was an accumulation of water in the mouth, causing constant expectoration of a thin transparent fluid, after which there was dryness of the fauces. The fancy became exalted, with a flow of good spirits, well pleased with every one; in about an hour this gradually died away, leaving a pain in the forehead, particularly above the superciliary ridges, of a heavy drawing character, together with throbbing of the anterior temporal artery; great drowsiness, with drooping of the eyelids; at times rumbling with darting pain in the lower part of the abdomen. About 12 m. these symptoms had almost disappeared, when another teaspoonful of the tincture was taken, producing the same effects as those noted above, only in an aggravated degree, together with a constant desire to urinate, the urine passing very copiously and freely. On awaking the next morning a severe bruised sensation was experienced in the limbs, all the joints, and particularly in the small of the back, almost impeding motion, which disappeared after walking.

The bladder seemed much distended, and after evacuating the urine, which was very turbid and bot, a thick mucous sediment was thrown to the bottom of the chamber. The urine after being voided left a burning in the urethra, which continued nearly half an hour.

All the next day (Jan. 5th), there was experienced headache, and a discharge of a thin watery fluid from the urethra; the pain in the head was confined to the vertex and forehead, and was throbbing in character; there was also vertigo when rising, but particularly when yawning or stretching ; pain at times in the left eye, as though it were wearied, with

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