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tations (after first and fourth dose),92.—Crampy pains in epigastric region (after two hours),-2.

Abdomen.-Slight oppression near the liver (after second day),4Griping pain in umbilical region,... — [210.) Crampy pains in umbilical region (second day),"?:-Slight distension in the abdonien, with dull pain (afier four bours),-4. -Slight rumbling in the bowels (after fifteen minutes),-Bowels moved with a rumbling, leaving a feeling of emptiness afterward (after balf an hour),25.-Slight griping pain in the bowels (after eight hours and a half ),s-Severe colicky pains in the abdomen, increased when lying down (after first dose),210.-Contraction of the muscles in the lower part of the abdomen, as though they were all being drawn together over the region of the uterus; the region of the uterus, fallopian tubes, and ovaries felt very hard on pressure (after seventeen hours and a half),25.

Respiratory Organs.-Hacking cough (five minutes after first inhalation, and again three-quarters of an hour after),16 27. Could hardly breathe for about

a minute,19 -Oppressed, difficult, and rapid breathing'; feeling as if a weight were on the sternum, the oppressed breathiug remained during and after a walk of a mile, two hours after inbaling the drug; entirely passed off two hours later, 5 --[220.] Feeling of suffocation from palpitation of the heart,".

Chest.-Oppression of chest on walking about (after four hours),Seuse of oppression in the chest, especially at the lower part of the stercum (second day),*-Oppression at the end of the sternum on going down. stairs (after two hours and a quarter),"4.-A peculiar sensation in right lung or chest, not exactly a pain, however (soon)," - Drawing pain in left side between the seventh and ninth ribs, short but frequent (second day),". -Slight, dull, aching pain in right chest (after one hour and a quarter); pain more severe (after two hours),30: _Sharp pain in region of heart, relieved by eructations, which continued several days, 16 21 ---Pain in left side in region of heart, extending around to the back (after two hours), -A short contraction at the left of the heart, ill-defined (after second dose),44.

Heart and Pulse.—[230.] Stitching pains in the cardiac region and feeling of constriction,:: - Very violent palpitation,21c. — After exercise, palpitation of heart more violent than usual after the same amount of exercise,'' – Beating of pulse distinctly felt in fingers (after one hour and a balf),23.-Pulse accelerated (sixth day), -Pulse accelerated, full and hard (second day),".—Pulse increased about twelve beats in the minute, but I was unable to count it at once, owing to the confusion of the head," -Pulse accelerated by 10 or 12 beats (fifteen minutes after first dose); rose 20 beats, remained so a few minutes, and then gradually fell to normal standard (twelve minutes after 40 drops),'9. -Pulse 60 (after three hours),-0. -[240.] Pulse accelerated from 60 to 72, hard and full,"5. —Pulse 64, normally 70 (after second dose),44.—Pulse 83 (before taking medicine); 63 (in twenty-five minutes) ; 73.(after two hours); did not return to usual state for two days,?16. - Pulse 63 (before medicine); 68 (after ten minutes); 65, not regular (after twenty minutes); 68 (after thirty minutes); 63 (after one hour and a half); 70 and irregular (after one hour and three-quarters); 65 (after two hours); 63 and quite full (after two hours and threequarters)," —Pulse not accelerated but irregular in action, almost impossible to count,

Neck and Back.-Stiffness and pain in right side of neck and right shoulder, extends down right arm to wrist, neuralgic or rheumatic in char

16 27

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acter (in five minutes); pains return (after three hours and a half ),21. – Twinges near the dorsal vertebræ (after four hours),4.- Pain and weakness in lower lumbar region, in the morning (second day),".

Extremities.-Trembling of the limbs, with feeling of weakness, ". - Weakness in the limbs, 21c.—[250.] Lameness and soreness of muscles of arms and thighs entirely cured, perhaps by time,”:-Soreness of extensor muscles (after four hours),-.--Uneasy feeling in extremities (after half an hour),23.

Superior Extremities.—Slight disconfort in right shoulder (after twenty-seven minutes),28 — Lameness of flexor muscles of right arm (after forty-five minutes)," - Pain and stiffness in right arm, particularly near wrist, much increased by motion; effort of bending the arm or of writing very painful (after one hour and a half),".- Drawing, tensive pains in the wrist and finger joints of left hand,'*. — Pulsations distinctly felt in the tips of the fingers,

Inferior Eartremities.--Stiffness in lower limbs (in three hours and a half),a.-Rheumatic pains in left leg and knee, followed by soreness in right arm and shoulder; then lameness in right scapula (after four hours),24 —[260.] Sharp pain in the calf of the left leg (after eight hours and a half ),25.

Generalities.-Ladendorf and Dr. O. J. B. Wolff investigated the action of Nitrite of amyl on blood by microscopic examination. A drop of freshly drawn blood was placed on a slide under the objective, and a little spill of wood moistened with Amyl nitrite approximated. When the spill was 1.5 to 2 millimeters Góth to sth inch nearly) distant from the blood-drop, there immediately occurred, independently of the movements of the blood-luid, a violent agitation of the blood-corpuscles in the neighborhood of the spill; moving rapidly away from it, and returning, rather less quickly, to their old place, in a curved line, and then madly hastening (sic) to begin the same game again. Simultaneous experiments with indifferent bodies gave only the ordinary physical movements. The direct contact of the Amyl nitrite is said to have produced solution of corpuscles, with formation of lakelike pigment (color of winter cherry). The vapor first made the corpuscles pale, then dissolved them. Ladendorf did not employ a moist chamber; but be ascribes the whole of the effects of Amyl nitrite to this action on the blood-corpuscles, causing a backward pressure on the pulmonary arterial system first, and then on the systemic, finally inducing venous congestion as a natural consequence, 13. — Immediately feli a sense of fulness of head and flushing of face, wbich increased during one minute to positive agony, without pain; a violent palpitation of the heart now began, which shook the whole body; consciousness was still perfect, and there was no feeling of alarm. I now felt myself sinking to the floor, which seemed a voluntary act, for I eased my descent by means of two tables between which I was starding, lowering myself gently until stretched at full length; my last conscious act was the endeavor to hold the head erect lest the surcharged cerebral vessels should become yet fuller. My first act of returning consciousness was to recognize my attendant, who was giving me Chloroform. Not five minutes elapsed between the first inhalation of the nitrite and complete restoration, complete save for anæsthesia at the second phalanges of the middle and ring fingers of the left hand. This symptom continued about one hour. I was informed that my “face and eyes were a deep, livid red color," and that I “looked horribly," 29.- Entering the room at 10.25 P.m. I noticed the pungent odor of the nitrite. The effects were: An increasing sense of stupefaction, with flushing of the face and scalp. A sudden smarting of the conjunctivæ, with injection of the ocular conjunctivæ, and dimness of vision as if caused by a film. Subacute smartings in præcordial region; then in right renal region ; then in right axilla ; then at mid-sterpunı ; then in lumbar region ; then in lower lobe of right lung, at apex of the heart, and in lower lobe of left lung, with tenderness on pressure. Increasing dyspnea, with sneezings, nasal catarrh, and sighing respiration. Pulse (sitting) 68, small, feeble. The smartings changed position rapidly, being most persistent in the eyes, bases of the lungs, and spine. After enduring the increasing discomforts for some twenty minutes, respiration became a series of gaspings, whereupon I beat a retreat (first day). On awaking the pains returned with increased intensity, especially in spine, lungs, and conjunctive; with shifting pains, caused by movement, on dorsal surface of right hand, on left patella, and from left thumb to axilla ; with catarrhal symptoms, and severe frontoorbital cephalalgia. Many of these symptoms returned, with varying intensities, during the day; at times accompanied by sighing respiration. They were intensified by the odor of being again inhaled. Urine clear, acid ; sp. gr. 1014; free from albumen and phosphates; light cloud of an oxalate (probably lime), and distinct traces of sugar. Pulse (sitting) 78 to 84, feeble (second day). During morning a dull aching in cervical region, which gradually moved to suboccipital region, and then passed away. During the evening, smartings in the eyeballs, with injection of the conjunctivæ. Urine clear, acid ; sp. gr. 1020; traces of oxalates and sugar in marked quantity (third day). After rising, sneezed violently three times; severe occipito-frontal headache, felt mostly in suboccipital region; smarting of the conjunctive and weakuess of vision. Urine clear, free, acid ; sp. gr. 1016, saccharine. Pulse (sitting) 80; general lassitude (fourth day). Occipito-frontal headache, with achings in right renal region ; smartings of conjunctive. Urine clear, free, acid; sp. gr. 1020; saccharide (fifth day). Severe occipito-cervical achings, with increased frequency of the renal achings; smartings of conjunctivæ Urine clear, free, acid; sp. gr. 1020; abundance of sugar. Pulse (sitting) 70, regular (sixth day). Constant occipital headache, and achings across loins. Ürine clear, acid; sp. gr. 1018; less sugar (seventh day). Achings remain, with weakness of eyes, and smartings of conjunctive. Urine clear, acid ; sp; gr. 1016; traces of sugar (ninth day). Slight occipital headache, and smartings of conjunctivæ; returns of loin achings on waking, and on lying down at night. Urine clear, acid ; sp. gr. 1018; traces of sugar (twelfth day). Remains of suboccipital and loin achings, increased by fatigue. Urine clear, acid; sp. gr. 1012; mere trace of sugar. Pulse (sitting) 66, regular, feeble (nineteenth day). Weakness of vision persists. Urine clear, acid; sp. gr. 1014; traces of sugar. Pulse (sitting) 68, regular (fortieth day). The achings mentioned were increased by fatigue, and were most marked during the evenings,”-General weakness, with tendency to perspire easily on slight exertion (after nine hours),20.—During the day, general lassitude; did not feel like doing anything. This may have been owing to the weather (second day),20 —Restless (second day), -Great restlessness and uneasiness, 15.-Stiffness as if from having taken cold (in five minutes)," — Trembling sensation all over, and cannot sit still for fear of something dreadful happening, 16 27. — [270.] Tingling sensation in different parts of the body (after one hour and a quarter), -All symptoms relieved by exercise out of doors, 16 27.

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Skin.-He advises the lips, nostrils, etc., to be guarded from direct contact, as vesication is apt to arise if they are not so protected,'.

Sleep.-Drowsiness (second day),"? - Very drowsy (after forty minutes), 6. —Confused and drowsy (sixth day),?. -Overpowering drowsiness, lasting more than an hour (after first dose),214. -Sleep restless, full of anxious dreams; frequent waking, with severe pain in temples and in the stomach and bowels (first night),".

Fever.-Slight chill crept over the back and sides (sixteen minutes after 20 drops)," - His observations, embracing more than forty cases, were made partly upon sane persons, and partly on those recovering from different psychoses. The time selected was generally from 3 to 5 P.M., or after 8 P.M. The thermometer was placed in the mouth, between the cheek and the superior maxilla. The general result is, that the temperature always rises after the inhalation. Many circumstances affect the amount of this rise, such as the quantity of vapor inhaled, the surrounding atmosphere, the contraction of bloodvessels, individual peculiarities, etc.; so that two persons with the same initial temperature may show differences of 0.53° Cent. It is interesting that this rise can generally be demonstrated for from one to two hours. A table of thirty-six cases is given; the smallest maximal elevation was 0.1° Cent. (in three cases); the bighest maximal rise was 1.88° Cent. (one case); the mean rise was 0.39° Cent. (thirty-six cases). This elevation is very evident in the course of the second minute of inhalation. The purer the preparations inhaled, the more evident the effect. The effect on bis pupils was not very uniform. In all cases when simultaneous observations were made, the axillary temperature rose correspondingly,'* - [280.] Hands moist, head and body felt warm, especially the abdomen (thirteen minutes after .second dose); greater warmth espe. cially in the chest (thirty minutes after second dose); heat was felt in head and along esophagus to stomach ; heat remained over half an hour (five minutes after 10 drops); heat was experienced principally in stomach skin moist (ten minutes after 20 drops),19:— Redness and heat of head, face, and neck, with violent throbbing in top of head and carotids, 16. -Heat in face,"c. -Slight heat in face (after twenty minutes),23.—Heat and redness of face (immediately)," —Marked feeling of heat in face, with flushed face (after three-quarters of an hour)," —Heat in left ear (after forty-five minutes), 6. –Profuse perspiration on hands, 216.—Skin moist, free perspiration during moderate exercise (second day),2 – Though not warm perspiration started freely, cold chills at the same time running down my back,!.

Conditions.--- Aggravation.- (Morning), On rising, vertigo; headache; nausea.—(Heat of room), Pain in occiput.-(Lying down), Griping in abdomen.-(Motion), Pain and stiffness in arm.-(Writing), Pain in occiput.

Amelioration.-(Eructations), Pain in region of heart.-(Motion), Constriction of throat.

ANACARDIUM. Authorities. 12, P. Le B. Stickney, M.D., Phil. Med. Exam., vol. vii, 1844, p. 133, J. B., aged sixteen years, was poisoned by rubbing upon the back of the hand the dried juice of the cashew nut; 13, Dr. F. Taylor, Med. Times and Gaz., 1875 (2), p. 519, a boy, aged thirteen years, painted the figure of an anchor on his left arm with the juice of the Indian marking nut; 14, Dr. Yeldham, Montb. Hom. Rev., vol. xx, p. 95, A. B., aged

twenty-eight years, let some of the juice of the bean get into an abrasion on his left wrist.

The effects of the poison was first manifested by an excessive inflammation of the affected part (the hands), accompanied with pain and an almost intolerable itching. This was followed by an eruption of small red pimples, which soon suppurated, bearing a close resemblance to the pustular eruption produced by croton oil. In a short time, these pustules discharged a very small quantity of thin pus, coalesced, and becaine covered with a thin pellicle, filled with serum, giving to the skin the appearance of having been covered with small blisters. The blistering or desquamation of the cuticle was confined to the part upon which the juice had been applied, excepting the lips, which being repeatedly rubbed by the hands, presented a similar appearance, whilst the swelling and pustular eruption extended to the other parts of the body. The penis and scrotum were enormously distended by an ædematous swelling, but the eruption was confined entirely to the scrotum. The urine, which was voided in large quantities, was of a dark-green color, possessed its natural smell, and deposited no sediment. On the first appearance of the swelling, there was some fever and thirst,"? -In one week his arm became red, and a number of small pimples appeared. In the night his face became swollen and red, and the next day the abdomen and thighs on which he had rested the arm were red. The left hand, forearm, and the lower half of the upper arm were swollen, and of a bright-red color, resembling that of erysipelas. On the front of the forearm was an abrasion of the skin, shaped somewhat like an anchor, and presenting some black points, which the boy stated were the remains of the material used. Over the rest of the forearm were many vesicles of various sizes and shapes, mixed, especially at the back of the forearm, with minute pustules. The swollen arm did not pit ou slight pressure, but the color readily disappeared for the time. On the back of the right hand, and on the front of the wrist, were a few raised spots, surmounted by minute white pustules. The face presented a similar imflammatory condition. The redness and swelling affected both eyes (the left being quite closed), as well as the upper lip, the chin, and back of the right cheek, where there were a few isolated, raised, red spots. The color was sharply defined, and on the chin was a yellow crust resembling that of eczema. On the inner side of each thigh at the upper part was a large, red, less sharply defined patch, with one or two transparent vesicles; and on the lower part of the abdomen were a few spots resembling those on the right hand and wrist. The eruption caused considerable itching, - [660] About twelve hours after the wound itched, and he scratched it and increased the irritation. On the afternoon of the next day, vesicles made their appearance around the wound, and higher up the arm towards the elbow. The skin became hot, inflamed, and of a deep-red color; this condition extending upward above the elbow, and occupying the whole of the anterior and under aspects of the limb. At first there was not much itching, but on the second day the itching was considerable, and so much aggravated at night as to prevent him sleeping. On the evening of the third day the scrotum became sore, red, and inflamed, but without vesication; and at the same time the face was attacked, the eyelids and upper part of the right cheek presenting all the appearance of a sharp attack of erysipelas. The skin, he said, felt hot, stiff, and burning. There was also a red patch at the bend of the right arm, and on the right hand. Two days later the arm was more swollen and tense, the redness deeper and

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