Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the LiverLippincott Williams & Wilkins, 1999 - 789 sider Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury. |
Indhold
GENERAL CONSIDERATIONS | 1 |
The Spectrum of Hepatotoxicity | 3 |
Hepatic Metabolism of Foreign Compounds | 11 |
Vulnerability of the Liver to Toxic Injury | 41 |
Expressions of Hepatotoxicity | 61 |
Classification of Hepatotoxins and Mechanisms of Toxicity | 111 |
Hepatotoxic Effects of Ethanol | 147 |
Chemical Hepatocarcinogenesis | 177 |
Occupational Toxicity | 365 |
Hepatotoxicity in the Household | 391 |
The Hepatotoxic Potential of a Polluted Environment | 409 |
IATROGENIC HEPATIC INJURY | 425 |
DrugInduced Liver Disease | 427 |
Anesthetic Agents | 457 |
Psychotropic and Anticonvulsant Agents | 483 |
Drugs Used to Treat Rheumatic and Musculospastic Disease | 517 |
EXPERIMENTAL HEPATOTOXICITY | 199 |
Experimental Hepatotoxicity | 201 |
Haloaliphatics Phosphorus Iron and Copper | 229 |
Indirect Cytotoxic Hepatotoxins | 255 |
Toxic Cholestasis | 295 |
ENVIRONMENTAL HEPATOTOXICITY | 325 |
Syndromes of Environmental Hepatotoxicity | 327 |
Hormonal Derivatives and Related Drugs | 555 |
Hepatic Injury from the Treatment of Infectious and Parasitic Diseases 589 | 639 |
Hepatotoxic Effects of Oncotherapeutic and Immunosuppressive Agents | 673 |
Miscellaneous Drugs and Diagnostic Chemicals | 709 |
Afterthoughts on Hepatotoxicology | 743 |
| 765 | |
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