AddictionOxford University Press, 23. aug. 2018 - 144 sider Substance addiction is a chronic, relapsing disorder characterized by a compulsion to take a substance despite potential consequences. Addiction, second edition offers a clear and succinct overview of the brain science underpinning substance addiction. Focusing on the nature of addiction as a brain disorder, this resource discusses a range of different behavioural traits such as impulsivity and reward dependence, and looks at the critical role of kinetic and pharmacological factors. All chapters have been fully updated to provide readers with a quick-reference guide to the latest research on pharmacological and non-pharmacological treatments for addition, and feature helpful key points and further reading sources. In addition, two new chapters on nicotine addiction and appetite hormones have been added to ensure the reader is kept abreast of the most recent discussions in the field of research. |
Indhold
1 What is addiction? | 1 |
2 Burden of addiction | 7 |
3 Key elements of addiction | 17 |
4 Neurobiological processes in addiction | 23 |
5 Drug pharmacokinetics and abuse liability | 31 |
6 Pharmocodynamics of addictive substances | 37 |
7 The dopamine system and addiction | 43 |
8 The GABA system and addiction | 55 |
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acamprosate activity addictive substances agonist alcohol craving alcohol dependence amphetamine amygdala antagonist attenuate Baclofen behaviour binding brain regions bupropion caudate CHAPTER chronic cigarette cingulate clinical cocaine dependence cognitive control consumption Copyright cues disorders DLPFC dopamine neurons dopamine release dose drug effects of substances efficacy EXE Placebo exenatide Figure functioning GABA receptors GABAergic gabapentin genetic ghrelin glutamate heroin humans increase induced inhibition inhibitory involved medications methadone methamphetamine methylphenidate midbrain modulating motivation mu opioid receptor NAcc nAChRs naltrexone neural neurons neuroplasticity Neuropsychopharmacology neurotransmitter nicotine abstinence nicotine addiction NMDA receptor nucleus accumbens Opiates opioid receptor orbitofrontal cortex orexin pathway permission from Elsevier Pharmacology placebo potential prefrontal cortex presynaptic processes putamen reducing cocaine reinforcing effects relapse Reprinted Research response reuptake role shown significantly smoking stimulants striatal subjective effects substance abuse substance addiction substances of abuse substances of addiction synaptic Tiagabine tobacco Topiramate treatment varenicline ventral striatum Volkow ND withdrawal
